Cargando…
Loop Diuretics Are Associated with Increased Risk of Hospital-Acquired Acute Kidney Injury in Adult Patients: A Retrospective Study
Background: The association between loop diuretics and acute kidney injury (AKI) remains unclear. Methods: The population studied was selected from the Epidemiology of AKI in Chinese Hospitalized patients (EACH) study. Exposure to loop diuretics was defined as any filled prescription prior to the da...
Autores principales: | , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9267783/ https://www.ncbi.nlm.nih.gov/pubmed/35806949 http://dx.doi.org/10.3390/jcm11133665 |
_version_ | 1784743817559146496 |
---|---|
author | Zhou, Liping Li, Yanqin Gao, Qi Lin, Yuxin Su, Licong Chen, Ruixuan Cao, Yue Xu, Ruqi Luo, Fan Gao, Peiyan Zhang, Xiaodong Li, Pingping Nie, Sheng Tang, Ying Xu, Xin |
author_facet | Zhou, Liping Li, Yanqin Gao, Qi Lin, Yuxin Su, Licong Chen, Ruixuan Cao, Yue Xu, Ruqi Luo, Fan Gao, Peiyan Zhang, Xiaodong Li, Pingping Nie, Sheng Tang, Ying Xu, Xin |
author_sort | Zhou, Liping |
collection | PubMed |
description | Background: The association between loop diuretics and acute kidney injury (AKI) remains unclear. Methods: The population studied was selected from the Epidemiology of AKI in Chinese Hospitalized patients (EACH) study. Exposure to loop diuretics was defined as any filled prescription prior to the date when AKI was detected in patients with HA-AKI, and prior to the last date of SCr testing in those without AKI. The outcome was AKI, defined by the Kidney Disease Improving Global Outcomes criteria. Associations between loop diuretics and HA-AKI were examined by Cox proportional hazards models adjusted for baseline and time-dependent covariates. Results: Of the 150,020 patients, 16,437 (11.0%) were prescribed loop diuretics, and 5717 (3.8%) experienced HA-AKI events. The crude rates of HA-AKI in patients who were and were not prescribed loop diuretics were 1632 (9.9%) and 3262 (2.8%), respectively. A multivariate cox proportional hazards analysis showed that exposure to loop diuretics was associated with significantly increased risks of HA-AKI compared with non-users (hazard ratio (HR), 1.61; 95% CI (confidence interval), 1.55–1.67), other diuretics (HR, 1.09; 95% CI, 1.03–1.15), and osmotic diuretics (HR, 1.30; 95% CI, 1.20–1.42). Compared with other diuretics, the use of loop diuretics was associated with higher risks of HA-AKI in women, in patients without hypertension, in patients without heart failure, in patients without liver cirrhosis, and in patients not requiring surgery. Conclusions: Loop diuretics are widely used and are associated with increased risks of HA-AKI in hospitalized adults. Renal function should be more closely monitored during the use of loop diuretics. |
format | Online Article Text |
id | pubmed-9267783 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-92677832022-07-09 Loop Diuretics Are Associated with Increased Risk of Hospital-Acquired Acute Kidney Injury in Adult Patients: A Retrospective Study Zhou, Liping Li, Yanqin Gao, Qi Lin, Yuxin Su, Licong Chen, Ruixuan Cao, Yue Xu, Ruqi Luo, Fan Gao, Peiyan Zhang, Xiaodong Li, Pingping Nie, Sheng Tang, Ying Xu, Xin J Clin Med Article Background: The association between loop diuretics and acute kidney injury (AKI) remains unclear. Methods: The population studied was selected from the Epidemiology of AKI in Chinese Hospitalized patients (EACH) study. Exposure to loop diuretics was defined as any filled prescription prior to the date when AKI was detected in patients with HA-AKI, and prior to the last date of SCr testing in those without AKI. The outcome was AKI, defined by the Kidney Disease Improving Global Outcomes criteria. Associations between loop diuretics and HA-AKI were examined by Cox proportional hazards models adjusted for baseline and time-dependent covariates. Results: Of the 150,020 patients, 16,437 (11.0%) were prescribed loop diuretics, and 5717 (3.8%) experienced HA-AKI events. The crude rates of HA-AKI in patients who were and were not prescribed loop diuretics were 1632 (9.9%) and 3262 (2.8%), respectively. A multivariate cox proportional hazards analysis showed that exposure to loop diuretics was associated with significantly increased risks of HA-AKI compared with non-users (hazard ratio (HR), 1.61; 95% CI (confidence interval), 1.55–1.67), other diuretics (HR, 1.09; 95% CI, 1.03–1.15), and osmotic diuretics (HR, 1.30; 95% CI, 1.20–1.42). Compared with other diuretics, the use of loop diuretics was associated with higher risks of HA-AKI in women, in patients without hypertension, in patients without heart failure, in patients without liver cirrhosis, and in patients not requiring surgery. Conclusions: Loop diuretics are widely used and are associated with increased risks of HA-AKI in hospitalized adults. Renal function should be more closely monitored during the use of loop diuretics. MDPI 2022-06-24 /pmc/articles/PMC9267783/ /pubmed/35806949 http://dx.doi.org/10.3390/jcm11133665 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Zhou, Liping Li, Yanqin Gao, Qi Lin, Yuxin Su, Licong Chen, Ruixuan Cao, Yue Xu, Ruqi Luo, Fan Gao, Peiyan Zhang, Xiaodong Li, Pingping Nie, Sheng Tang, Ying Xu, Xin Loop Diuretics Are Associated with Increased Risk of Hospital-Acquired Acute Kidney Injury in Adult Patients: A Retrospective Study |
title | Loop Diuretics Are Associated with Increased Risk of Hospital-Acquired Acute Kidney Injury in Adult Patients: A Retrospective Study |
title_full | Loop Diuretics Are Associated with Increased Risk of Hospital-Acquired Acute Kidney Injury in Adult Patients: A Retrospective Study |
title_fullStr | Loop Diuretics Are Associated with Increased Risk of Hospital-Acquired Acute Kidney Injury in Adult Patients: A Retrospective Study |
title_full_unstemmed | Loop Diuretics Are Associated with Increased Risk of Hospital-Acquired Acute Kidney Injury in Adult Patients: A Retrospective Study |
title_short | Loop Diuretics Are Associated with Increased Risk of Hospital-Acquired Acute Kidney Injury in Adult Patients: A Retrospective Study |
title_sort | loop diuretics are associated with increased risk of hospital-acquired acute kidney injury in adult patients: a retrospective study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9267783/ https://www.ncbi.nlm.nih.gov/pubmed/35806949 http://dx.doi.org/10.3390/jcm11133665 |
work_keys_str_mv | AT zhouliping loopdiureticsareassociatedwithincreasedriskofhospitalacquiredacutekidneyinjuryinadultpatientsaretrospectivestudy AT liyanqin loopdiureticsareassociatedwithincreasedriskofhospitalacquiredacutekidneyinjuryinadultpatientsaretrospectivestudy AT gaoqi loopdiureticsareassociatedwithincreasedriskofhospitalacquiredacutekidneyinjuryinadultpatientsaretrospectivestudy AT linyuxin loopdiureticsareassociatedwithincreasedriskofhospitalacquiredacutekidneyinjuryinadultpatientsaretrospectivestudy AT sulicong loopdiureticsareassociatedwithincreasedriskofhospitalacquiredacutekidneyinjuryinadultpatientsaretrospectivestudy AT chenruixuan loopdiureticsareassociatedwithincreasedriskofhospitalacquiredacutekidneyinjuryinadultpatientsaretrospectivestudy AT caoyue loopdiureticsareassociatedwithincreasedriskofhospitalacquiredacutekidneyinjuryinadultpatientsaretrospectivestudy AT xuruqi loopdiureticsareassociatedwithincreasedriskofhospitalacquiredacutekidneyinjuryinadultpatientsaretrospectivestudy AT luofan loopdiureticsareassociatedwithincreasedriskofhospitalacquiredacutekidneyinjuryinadultpatientsaretrospectivestudy AT gaopeiyan loopdiureticsareassociatedwithincreasedriskofhospitalacquiredacutekidneyinjuryinadultpatientsaretrospectivestudy AT zhangxiaodong loopdiureticsareassociatedwithincreasedriskofhospitalacquiredacutekidneyinjuryinadultpatientsaretrospectivestudy AT lipingping loopdiureticsareassociatedwithincreasedriskofhospitalacquiredacutekidneyinjuryinadultpatientsaretrospectivestudy AT niesheng loopdiureticsareassociatedwithincreasedriskofhospitalacquiredacutekidneyinjuryinadultpatientsaretrospectivestudy AT tangying loopdiureticsareassociatedwithincreasedriskofhospitalacquiredacutekidneyinjuryinadultpatientsaretrospectivestudy AT xuxin loopdiureticsareassociatedwithincreasedriskofhospitalacquiredacutekidneyinjuryinadultpatientsaretrospectivestudy AT loopdiureticsareassociatedwithincreasedriskofhospitalacquiredacutekidneyinjuryinadultpatientsaretrospectivestudy |