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Nanoswimmers Based on Capped Janus Nanospheres

Nanoswimmers are synthetic nanoscale objects that convert the available surrounding free energy to a directed motion. For example, bacteria with various flagella types serve as textbook examples of the minuscule swimmers found in nature. Along these lines, a plethora of artificial hybrid and non-hyb...

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Detalles Bibliográficos
Autores principales: Piskunen, Petteri, Huusela, Martina, Linko, Veikko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9267829/
https://www.ncbi.nlm.nih.gov/pubmed/35806570
http://dx.doi.org/10.3390/ma15134442
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author Piskunen, Petteri
Huusela, Martina
Linko, Veikko
author_facet Piskunen, Petteri
Huusela, Martina
Linko, Veikko
author_sort Piskunen, Petteri
collection PubMed
description Nanoswimmers are synthetic nanoscale objects that convert the available surrounding free energy to a directed motion. For example, bacteria with various flagella types serve as textbook examples of the minuscule swimmers found in nature. Along these lines, a plethora of artificial hybrid and non-hybrid nanoswimmers have been introduced, and they could find many uses, e.g., for targeted drug delivery systems (TDDSs) and controlled drug treatments. Here, we discuss a certain class of nanoparticles, i.e., functional, capped Janus nanospheres that can be employed as nanoswimmers, their subclasses and properties, as well as their various implementations. A brief outlook is given on different fabrication and synthesis methods, as well as on the diverse compositions used to prepare nanoswimmers, with a focus on the particle types and materials suitable for biomedical applications. Several recent studies have shown remarkable success in achieving temporally and spatially controlled drug delivery in vitro using Janus-particle-based TDDSs. We believe that this review will serve as a concise introductory synopsis for the interested readers. Therefore, we hope that it will deepen the general understanding of nanoparticle behavior in biological matrices.
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spelling pubmed-92678292022-07-09 Nanoswimmers Based on Capped Janus Nanospheres Piskunen, Petteri Huusela, Martina Linko, Veikko Materials (Basel) Review Nanoswimmers are synthetic nanoscale objects that convert the available surrounding free energy to a directed motion. For example, bacteria with various flagella types serve as textbook examples of the minuscule swimmers found in nature. Along these lines, a plethora of artificial hybrid and non-hybrid nanoswimmers have been introduced, and they could find many uses, e.g., for targeted drug delivery systems (TDDSs) and controlled drug treatments. Here, we discuss a certain class of nanoparticles, i.e., functional, capped Janus nanospheres that can be employed as nanoswimmers, their subclasses and properties, as well as their various implementations. A brief outlook is given on different fabrication and synthesis methods, as well as on the diverse compositions used to prepare nanoswimmers, with a focus on the particle types and materials suitable for biomedical applications. Several recent studies have shown remarkable success in achieving temporally and spatially controlled drug delivery in vitro using Janus-particle-based TDDSs. We believe that this review will serve as a concise introductory synopsis for the interested readers. Therefore, we hope that it will deepen the general understanding of nanoparticle behavior in biological matrices. MDPI 2022-06-24 /pmc/articles/PMC9267829/ /pubmed/35806570 http://dx.doi.org/10.3390/ma15134442 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Piskunen, Petteri
Huusela, Martina
Linko, Veikko
Nanoswimmers Based on Capped Janus Nanospheres
title Nanoswimmers Based on Capped Janus Nanospheres
title_full Nanoswimmers Based on Capped Janus Nanospheres
title_fullStr Nanoswimmers Based on Capped Janus Nanospheres
title_full_unstemmed Nanoswimmers Based on Capped Janus Nanospheres
title_short Nanoswimmers Based on Capped Janus Nanospheres
title_sort nanoswimmers based on capped janus nanospheres
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9267829/
https://www.ncbi.nlm.nih.gov/pubmed/35806570
http://dx.doi.org/10.3390/ma15134442
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