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Impact of Cardiopulmonary Resuscitation of Donors on Days Alive and Out of Hospital after Orthotopic Heart Transplantation

Background: The number of patients waiting for heart transplantation (HTX) is increasing. Optimizing the use of all available donor hearts is crucial. While mortality seems not to be affected by donor cardiopulmonary resuscitation (CPR), the impact of donor CPR on days alive and out of hospital (DAO...

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Autores principales: Roth, Sebastian, M’Pembele, René, Nucaro, Anthony, Stroda, Alexandra, Tenge, Theresa, Lurati Buse, Giovanna, Sixt, Stephan U., Westenfeld, Ralf, Rellecke, Philipp, Tudorache, Igor, Hollmann, Markus W., Aubin, Hug, Akhyari, Payam, Lichtenberg, Artur, Huhn, Ragnar, Boeken, Udo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9267911/
https://www.ncbi.nlm.nih.gov/pubmed/35807139
http://dx.doi.org/10.3390/jcm11133853
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author Roth, Sebastian
M’Pembele, René
Nucaro, Anthony
Stroda, Alexandra
Tenge, Theresa
Lurati Buse, Giovanna
Sixt, Stephan U.
Westenfeld, Ralf
Rellecke, Philipp
Tudorache, Igor
Hollmann, Markus W.
Aubin, Hug
Akhyari, Payam
Lichtenberg, Artur
Huhn, Ragnar
Boeken, Udo
author_facet Roth, Sebastian
M’Pembele, René
Nucaro, Anthony
Stroda, Alexandra
Tenge, Theresa
Lurati Buse, Giovanna
Sixt, Stephan U.
Westenfeld, Ralf
Rellecke, Philipp
Tudorache, Igor
Hollmann, Markus W.
Aubin, Hug
Akhyari, Payam
Lichtenberg, Artur
Huhn, Ragnar
Boeken, Udo
author_sort Roth, Sebastian
collection PubMed
description Background: The number of patients waiting for heart transplantation (HTX) is increasing. Optimizing the use of all available donor hearts is crucial. While mortality seems not to be affected by donor cardiopulmonary resuscitation (CPR), the impact of donor CPR on days alive and out of hospital (DAOH) is unclear. Methods: This retrospective study included adults who underwent HTX at the University Hospital Duesseldorf, Germany from 2010–2020. Main exposure was donor-CPR. Secondary exposure was the length of CPR. The primary endpoint was DAOH at one year. Results: A total of 187 patients were screened and 171 patients remained for statistical analysis. One-year mortality was 18.7%. The median DAOH at one year was 295 days (interquartile range 206–322 days). Forty-two patients (24.6%) received donor-CPR hearts. The median length of CPR was 15 (9–21) minutes. There was no significant difference in DAOH between patients with donor-CPR hearts versus patients with no-CPR hearts (CPR: 291 days (211–318 days) vs. no-CPR: 295 days (215–324 days); p = 0.619). Multivariate linear regression revealed that there was no association between length of CPR and DAOH (unstandardized coefficients B: −0.06, standard error: 0.81, 95% CI −1.65–1.53, p = 0.943). Conclusions: Donor CPR status and length of CPR are not associated with reduced DAOH at one year after HTX.
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spelling pubmed-92679112022-07-09 Impact of Cardiopulmonary Resuscitation of Donors on Days Alive and Out of Hospital after Orthotopic Heart Transplantation Roth, Sebastian M’Pembele, René Nucaro, Anthony Stroda, Alexandra Tenge, Theresa Lurati Buse, Giovanna Sixt, Stephan U. Westenfeld, Ralf Rellecke, Philipp Tudorache, Igor Hollmann, Markus W. Aubin, Hug Akhyari, Payam Lichtenberg, Artur Huhn, Ragnar Boeken, Udo J Clin Med Article Background: The number of patients waiting for heart transplantation (HTX) is increasing. Optimizing the use of all available donor hearts is crucial. While mortality seems not to be affected by donor cardiopulmonary resuscitation (CPR), the impact of donor CPR on days alive and out of hospital (DAOH) is unclear. Methods: This retrospective study included adults who underwent HTX at the University Hospital Duesseldorf, Germany from 2010–2020. Main exposure was donor-CPR. Secondary exposure was the length of CPR. The primary endpoint was DAOH at one year. Results: A total of 187 patients were screened and 171 patients remained for statistical analysis. One-year mortality was 18.7%. The median DAOH at one year was 295 days (interquartile range 206–322 days). Forty-two patients (24.6%) received donor-CPR hearts. The median length of CPR was 15 (9–21) minutes. There was no significant difference in DAOH between patients with donor-CPR hearts versus patients with no-CPR hearts (CPR: 291 days (211–318 days) vs. no-CPR: 295 days (215–324 days); p = 0.619). Multivariate linear regression revealed that there was no association between length of CPR and DAOH (unstandardized coefficients B: −0.06, standard error: 0.81, 95% CI −1.65–1.53, p = 0.943). Conclusions: Donor CPR status and length of CPR are not associated with reduced DAOH at one year after HTX. MDPI 2022-07-03 /pmc/articles/PMC9267911/ /pubmed/35807139 http://dx.doi.org/10.3390/jcm11133853 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Roth, Sebastian
M’Pembele, René
Nucaro, Anthony
Stroda, Alexandra
Tenge, Theresa
Lurati Buse, Giovanna
Sixt, Stephan U.
Westenfeld, Ralf
Rellecke, Philipp
Tudorache, Igor
Hollmann, Markus W.
Aubin, Hug
Akhyari, Payam
Lichtenberg, Artur
Huhn, Ragnar
Boeken, Udo
Impact of Cardiopulmonary Resuscitation of Donors on Days Alive and Out of Hospital after Orthotopic Heart Transplantation
title Impact of Cardiopulmonary Resuscitation of Donors on Days Alive and Out of Hospital after Orthotopic Heart Transplantation
title_full Impact of Cardiopulmonary Resuscitation of Donors on Days Alive and Out of Hospital after Orthotopic Heart Transplantation
title_fullStr Impact of Cardiopulmonary Resuscitation of Donors on Days Alive and Out of Hospital after Orthotopic Heart Transplantation
title_full_unstemmed Impact of Cardiopulmonary Resuscitation of Donors on Days Alive and Out of Hospital after Orthotopic Heart Transplantation
title_short Impact of Cardiopulmonary Resuscitation of Donors on Days Alive and Out of Hospital after Orthotopic Heart Transplantation
title_sort impact of cardiopulmonary resuscitation of donors on days alive and out of hospital after orthotopic heart transplantation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9267911/
https://www.ncbi.nlm.nih.gov/pubmed/35807139
http://dx.doi.org/10.3390/jcm11133853
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