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Effect of Pneumococcal Vaccine on Mortality and Cardiovascular Outcomes: A Systematic Review and Meta-Analysis

Various studies have suggested the possible cardiovascular (CV) protective effects of the pneumococcal vaccine (PV). Therefore, we conducted a meta-analysis to assess the association between recipients of PV with mortality and CV outcomes among patients with and without established cardiovascular di...

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Autores principales: Jaiswal, Vikash, Ang, Song Peng, Lnu, Kriti, Ishak, Angela, Pokhrel, Nishan Babu, Chia, Jia Ee, Hajra, Adrija, Biswas, Monodeep, Matetic, Andrija, Dhatt, Ravinder, Mamas, Mamas A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9267914/
https://www.ncbi.nlm.nih.gov/pubmed/35807082
http://dx.doi.org/10.3390/jcm11133799
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author Jaiswal, Vikash
Ang, Song Peng
Lnu, Kriti
Ishak, Angela
Pokhrel, Nishan Babu
Chia, Jia Ee
Hajra, Adrija
Biswas, Monodeep
Matetic, Andrija
Dhatt, Ravinder
Mamas, Mamas A.
author_facet Jaiswal, Vikash
Ang, Song Peng
Lnu, Kriti
Ishak, Angela
Pokhrel, Nishan Babu
Chia, Jia Ee
Hajra, Adrija
Biswas, Monodeep
Matetic, Andrija
Dhatt, Ravinder
Mamas, Mamas A.
author_sort Jaiswal, Vikash
collection PubMed
description Various studies have suggested the possible cardiovascular (CV) protective effects of the pneumococcal vaccine (PV). Therefore, we conducted a meta-analysis to assess the association between recipients of PV with mortality and CV outcomes among patients with and without established cardiovascular disease. We performed a systematic literature search in PubMed, Embase, and Scopus for studies evaluating the effect of PV on mortality and CV outcomes. A total of 15 studies with 347,444 patients were included in the meta-analysis: 111,784 patients received PV (32%) and 235,660 patients were in the unvaccinated group (68%). Recipients of PV were associated with decreased all-cause mortality (HR, 0.76 (95% CI: 0.66 to 0.87), p < 0.001). PV was associated with a decrease in the incidence of myocardial infarction (MI) (HR, 0.73 (95% CI: 0.56–0.96), p = 0.02), without significant reduction in CV mortality (HR, 0.87 (95% CI: 0.72–1.07), p = 0.18) and stroke (HR, 1.01 (95% CI: 0.93–1.10), p = 0.82). Our study found PV was associated with decreased risk of all-cause mortality and MI. Future RCTs will be necessary to confirm benefits associated with receipt of PV.
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spelling pubmed-92679142022-07-09 Effect of Pneumococcal Vaccine on Mortality and Cardiovascular Outcomes: A Systematic Review and Meta-Analysis Jaiswal, Vikash Ang, Song Peng Lnu, Kriti Ishak, Angela Pokhrel, Nishan Babu Chia, Jia Ee Hajra, Adrija Biswas, Monodeep Matetic, Andrija Dhatt, Ravinder Mamas, Mamas A. J Clin Med Review Various studies have suggested the possible cardiovascular (CV) protective effects of the pneumococcal vaccine (PV). Therefore, we conducted a meta-analysis to assess the association between recipients of PV with mortality and CV outcomes among patients with and without established cardiovascular disease. We performed a systematic literature search in PubMed, Embase, and Scopus for studies evaluating the effect of PV on mortality and CV outcomes. A total of 15 studies with 347,444 patients were included in the meta-analysis: 111,784 patients received PV (32%) and 235,660 patients were in the unvaccinated group (68%). Recipients of PV were associated with decreased all-cause mortality (HR, 0.76 (95% CI: 0.66 to 0.87), p < 0.001). PV was associated with a decrease in the incidence of myocardial infarction (MI) (HR, 0.73 (95% CI: 0.56–0.96), p = 0.02), without significant reduction in CV mortality (HR, 0.87 (95% CI: 0.72–1.07), p = 0.18) and stroke (HR, 1.01 (95% CI: 0.93–1.10), p = 0.82). Our study found PV was associated with decreased risk of all-cause mortality and MI. Future RCTs will be necessary to confirm benefits associated with receipt of PV. MDPI 2022-06-30 /pmc/articles/PMC9267914/ /pubmed/35807082 http://dx.doi.org/10.3390/jcm11133799 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Jaiswal, Vikash
Ang, Song Peng
Lnu, Kriti
Ishak, Angela
Pokhrel, Nishan Babu
Chia, Jia Ee
Hajra, Adrija
Biswas, Monodeep
Matetic, Andrija
Dhatt, Ravinder
Mamas, Mamas A.
Effect of Pneumococcal Vaccine on Mortality and Cardiovascular Outcomes: A Systematic Review and Meta-Analysis
title Effect of Pneumococcal Vaccine on Mortality and Cardiovascular Outcomes: A Systematic Review and Meta-Analysis
title_full Effect of Pneumococcal Vaccine on Mortality and Cardiovascular Outcomes: A Systematic Review and Meta-Analysis
title_fullStr Effect of Pneumococcal Vaccine on Mortality and Cardiovascular Outcomes: A Systematic Review and Meta-Analysis
title_full_unstemmed Effect of Pneumococcal Vaccine on Mortality and Cardiovascular Outcomes: A Systematic Review and Meta-Analysis
title_short Effect of Pneumococcal Vaccine on Mortality and Cardiovascular Outcomes: A Systematic Review and Meta-Analysis
title_sort effect of pneumococcal vaccine on mortality and cardiovascular outcomes: a systematic review and meta-analysis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9267914/
https://www.ncbi.nlm.nih.gov/pubmed/35807082
http://dx.doi.org/10.3390/jcm11133799
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