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Evaluation of Cough Medication Use Patterns in Ambulatory Care Settings in the United States: 2003–2018

Using 2003–2018 National Ambulatory Medical Care Survey data for office-based visits and 2003–2018 National Hospital Ambulatory Medical Care Survey data for emergency department (ED) visits, we conducted cross-sectional analyses to examine cough medication (CM) use trends in the United States (US) a...

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Autores principales: Yang, Seonkyeong, Hincapie-Castillo, Juan M., Ke, Xuehua, Schelfhout, Jonathan, Ding, Helen, Sher, Mandel R., Zhou, Lili, Chang, Ching-Yuan, Wilson, Debbie L., Lo-Ciganic, Wei-Hsuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9267927/
https://www.ncbi.nlm.nih.gov/pubmed/35806956
http://dx.doi.org/10.3390/jcm11133671
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author Yang, Seonkyeong
Hincapie-Castillo, Juan M.
Ke, Xuehua
Schelfhout, Jonathan
Ding, Helen
Sher, Mandel R.
Zhou, Lili
Chang, Ching-Yuan
Wilson, Debbie L.
Lo-Ciganic, Wei-Hsuan
author_facet Yang, Seonkyeong
Hincapie-Castillo, Juan M.
Ke, Xuehua
Schelfhout, Jonathan
Ding, Helen
Sher, Mandel R.
Zhou, Lili
Chang, Ching-Yuan
Wilson, Debbie L.
Lo-Ciganic, Wei-Hsuan
author_sort Yang, Seonkyeong
collection PubMed
description Using 2003–2018 National Ambulatory Medical Care Survey data for office-based visits and 2003–2018 National Hospital Ambulatory Medical Care Survey data for emergency department (ED) visits, we conducted cross-sectional analyses to examine cough medication (CM) use trends in the United States (US) ambulatory care settings. We included adult (≥18 years) patient visits with respiratory-infection-related or non-infection-related cough as reason-for-visit or diagnosis without malignant cancer or benign respiratory tumor diagnoses. Using multivariable logistic regressions, we examined opioid antitussive, benzonatate, dextromethorphan-containing antitussive, and gabapentinoid use trends. From 2003–2005 to 2015–2018, opioid antitussive use decreased in office-based visits (8.8% to 6.4%, P(trend) = 0.03) but remained stable in ED visits (6.3% to 5.9%, P(trend) = 0.99). In both settings, hydrocodone-containing antitussive use declined over 50%. Benzonatate use more than tripled (office-based:1.6% to 4.8%; ED:1.5% to 8.0%; both P(trend) < 0.001). Dextromethorphan-containing antitussive use increased in ED visits (1.8% to 2.6%, P(trend) = 0.003) but stayed unchanged in office-based visits (3.8% to 2.7%; P(trend) = 0.60). Gabapentinoid use doubled in office-based visits (1.1% in 2006–2008 to 2.4% in 2015–2018, P(trend) < 0.001) but was negligible in ED visits. In US office-based and ED ambulatory care settings, hydrocodone-containing antitussive use substantially declined from 2003 to 2018, while benzonatate use more than tripled, and dextromethorphan-containing antitussive and gabapentinoid use remained low (<3%).
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spelling pubmed-92679272022-07-09 Evaluation of Cough Medication Use Patterns in Ambulatory Care Settings in the United States: 2003–2018 Yang, Seonkyeong Hincapie-Castillo, Juan M. Ke, Xuehua Schelfhout, Jonathan Ding, Helen Sher, Mandel R. Zhou, Lili Chang, Ching-Yuan Wilson, Debbie L. Lo-Ciganic, Wei-Hsuan J Clin Med Article Using 2003–2018 National Ambulatory Medical Care Survey data for office-based visits and 2003–2018 National Hospital Ambulatory Medical Care Survey data for emergency department (ED) visits, we conducted cross-sectional analyses to examine cough medication (CM) use trends in the United States (US) ambulatory care settings. We included adult (≥18 years) patient visits with respiratory-infection-related or non-infection-related cough as reason-for-visit or diagnosis without malignant cancer or benign respiratory tumor diagnoses. Using multivariable logistic regressions, we examined opioid antitussive, benzonatate, dextromethorphan-containing antitussive, and gabapentinoid use trends. From 2003–2005 to 2015–2018, opioid antitussive use decreased in office-based visits (8.8% to 6.4%, P(trend) = 0.03) but remained stable in ED visits (6.3% to 5.9%, P(trend) = 0.99). In both settings, hydrocodone-containing antitussive use declined over 50%. Benzonatate use more than tripled (office-based:1.6% to 4.8%; ED:1.5% to 8.0%; both P(trend) < 0.001). Dextromethorphan-containing antitussive use increased in ED visits (1.8% to 2.6%, P(trend) = 0.003) but stayed unchanged in office-based visits (3.8% to 2.7%; P(trend) = 0.60). Gabapentinoid use doubled in office-based visits (1.1% in 2006–2008 to 2.4% in 2015–2018, P(trend) < 0.001) but was negligible in ED visits. In US office-based and ED ambulatory care settings, hydrocodone-containing antitussive use substantially declined from 2003 to 2018, while benzonatate use more than tripled, and dextromethorphan-containing antitussive and gabapentinoid use remained low (<3%). MDPI 2022-06-25 /pmc/articles/PMC9267927/ /pubmed/35806956 http://dx.doi.org/10.3390/jcm11133671 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Yang, Seonkyeong
Hincapie-Castillo, Juan M.
Ke, Xuehua
Schelfhout, Jonathan
Ding, Helen
Sher, Mandel R.
Zhou, Lili
Chang, Ching-Yuan
Wilson, Debbie L.
Lo-Ciganic, Wei-Hsuan
Evaluation of Cough Medication Use Patterns in Ambulatory Care Settings in the United States: 2003–2018
title Evaluation of Cough Medication Use Patterns in Ambulatory Care Settings in the United States: 2003–2018
title_full Evaluation of Cough Medication Use Patterns in Ambulatory Care Settings in the United States: 2003–2018
title_fullStr Evaluation of Cough Medication Use Patterns in Ambulatory Care Settings in the United States: 2003–2018
title_full_unstemmed Evaluation of Cough Medication Use Patterns in Ambulatory Care Settings in the United States: 2003–2018
title_short Evaluation of Cough Medication Use Patterns in Ambulatory Care Settings in the United States: 2003–2018
title_sort evaluation of cough medication use patterns in ambulatory care settings in the united states: 2003–2018
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9267927/
https://www.ncbi.nlm.nih.gov/pubmed/35806956
http://dx.doi.org/10.3390/jcm11133671
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