Two New Seco-Labdane Diterpenoids from the Leaves of Callicarpa nudiflora

Two new seco-labdane diterpenoids, nudiflopene N (1) and nudiflopene O (2), and four known compounds were isolated from the leaves of Callicarpa nudiflora. The structures of the new compounds were established by 1D-, 2D-NMR, and HR-ESI-MS spectral analyses. Compounds 1–3 showed inhibitory activities...

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Detalles Bibliográficos
Autores principales: Guo, Xia, Zhang, Yao, Xiao, Yin, Zhou, Lu, Yin, Shaoyang, Sheng, Xifeng, Xiang, Hongling, Zou, Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9267982/
https://www.ncbi.nlm.nih.gov/pubmed/35807261
http://dx.doi.org/10.3390/molecules27134018
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author Guo, Xia
Zhang, Yao
Xiao, Yin
Zhou, Lu
Yin, Shaoyang
Sheng, Xifeng
Xiang, Hongling
Zou, Hui
author_facet Guo, Xia
Zhang, Yao
Xiao, Yin
Zhou, Lu
Yin, Shaoyang
Sheng, Xifeng
Xiang, Hongling
Zou, Hui
author_sort Guo, Xia
collection PubMed
description Two new seco-labdane diterpenoids, nudiflopene N (1) and nudiflopene O (2), and four known compounds were isolated from the leaves of Callicarpa nudiflora. The structures of the new compounds were established by 1D-, 2D-NMR, and HR-ESI-MS spectral analyses. Compounds 1–3 showed inhibitory activities on lipopolysaccharide-induced nitric oxide (NO) production in RAW264.7 cells, and new compounds 1–2 exhibited more potent inhibitory activity than compound 3. The cytotoxicity of compounds 1–3 against human hepatocellular carcinoma HepG2 cells and human gastric carcinoma SGC-7901 cells were evaluated, while all of them exhibited no cytotoxicity.
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spelling pubmed-92679822022-07-09 Two New Seco-Labdane Diterpenoids from the Leaves of Callicarpa nudiflora Guo, Xia Zhang, Yao Xiao, Yin Zhou, Lu Yin, Shaoyang Sheng, Xifeng Xiang, Hongling Zou, Hui Molecules Article Two new seco-labdane diterpenoids, nudiflopene N (1) and nudiflopene O (2), and four known compounds were isolated from the leaves of Callicarpa nudiflora. The structures of the new compounds were established by 1D-, 2D-NMR, and HR-ESI-MS spectral analyses. Compounds 1–3 showed inhibitory activities on lipopolysaccharide-induced nitric oxide (NO) production in RAW264.7 cells, and new compounds 1–2 exhibited more potent inhibitory activity than compound 3. The cytotoxicity of compounds 1–3 against human hepatocellular carcinoma HepG2 cells and human gastric carcinoma SGC-7901 cells were evaluated, while all of them exhibited no cytotoxicity. MDPI 2022-06-22 /pmc/articles/PMC9267982/ /pubmed/35807261 http://dx.doi.org/10.3390/molecules27134018 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Guo, Xia
Zhang, Yao
Xiao, Yin
Zhou, Lu
Yin, Shaoyang
Sheng, Xifeng
Xiang, Hongling
Zou, Hui
Two New Seco-Labdane Diterpenoids from the Leaves of Callicarpa nudiflora
title Two New Seco-Labdane Diterpenoids from the Leaves of Callicarpa nudiflora
title_full Two New Seco-Labdane Diterpenoids from the Leaves of Callicarpa nudiflora
title_fullStr Two New Seco-Labdane Diterpenoids from the Leaves of Callicarpa nudiflora
title_full_unstemmed Two New Seco-Labdane Diterpenoids from the Leaves of Callicarpa nudiflora
title_short Two New Seco-Labdane Diterpenoids from the Leaves of Callicarpa nudiflora
title_sort two new seco-labdane diterpenoids from the leaves of callicarpa nudiflora
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9267982/
https://www.ncbi.nlm.nih.gov/pubmed/35807261
http://dx.doi.org/10.3390/molecules27134018
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