Cargando…

In Silico Screening of Novel TMPRSS2 Inhibitors for Treatment of COVID-19

COVID-19, a pandemic caused by the virus SARS-CoV-2, has spread globally, necessitating the search for antiviral compounds. Transmembrane protease serine 2 (TMPRSS2) is a cell surface protease that plays an essential role in SARS-CoV-2 infection. Therefore, researchers are searching for TMPRSS2 inhi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Shuo, Fang, Xuexun, Wang, Ye
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9268035/ https://www.ncbi.nlm.nih.gov/pubmed/35807455 http://dx.doi.org/10.3390/molecules27134210

Ejemplares similares

In silico study on identification of novel MALT1 allosteric inhibitors
por: Zhang, Jinrui, et al.
Publicado: (2019)

TMPRSS2 inhibitor discovery facilitated through an in silico and biochemical screening platform
por: Peiffer, Amanda L., et al.
Publicado: (2021)

TMPRSS2 Inhibitor Discovery Facilitated through an In Silico and Biochemical Screening Platform
por: Peiffer, Amanda L., et al.
Publicado: (2023)

Discovery of TMPRSS2 Inhibitors from Virtual Screening as a Potential Treatment of COVID-19
por: Hu, Xin, et al.
Publicado: (2021)

Discovery of TMPRSS2 inhibitors from virtual screening
por: Hu, Xin, et al.
Publicado: (2021)

In-silico screening for identification of potential inhibitors against SARS-CoV-2 transmembrane serine protease 2 (TMPRSS2)
por: Barge, Sagar, et al.
Publicado: (2021)

Engineering substrate promiscuity in 2,4-dichlorophenol hydroxylase by in silico design
por: Wang, Ye, et al.
Publicado: (2018)

Discovery of novel TMPRSS2 inhibitors for COVID-19 using in silico fragment-based drug design, molecular docking, molecular dynamics, and quantum mechanics studies
por: Alzain, Abdulrahim A., et al.
Publicado: (2022)

Virtual Screening on Marine Natural Products for Discovering TMPRSS2 Inhibitors
por: Mahmudpour, Mehdi, et al.
Publicado: (2021)

A Suite of TMPRSS2 Assays for Screening Drug Repurposing Candidates as Potential Treatments of COVID-19
por: Shrimp, Jonathan H., et al.
Publicado: (2022)

An Enzymatic TMPRSS2 Assay for Assessment of Clinical Candidates and Discovery of Inhibitors as Potential Treatment of COVID-19
por: Shrimp, Jonathan H., et al.
Publicado: (2020)

Computational screening of camostat and related compounds against human TMPRSS2: A potential treatment of COVID-19
por: Sharma, Tanuj, et al.
Publicado: (2022)

SARS-CoV-2 entry inhibitors by dual targeting TMPRSS2 and ACE2: An in silico drug repurposing study
por: Baby, Krishnaprasad, et al.
Publicado: (2021)

TMPRSS2: Potential Biomarker for COVID‐19 Outcomes
por: Strope, Jonathan D., et al.
Publicado: (2020)

The Transmembrane Protease TMPRSS2 as a Therapeutic Target for COVID-19 Treatment
por: Wettstein, Lukas, et al.
Publicado: (2022)

Identification of novel TMPRSS2 inhibitors for COVID-19 using e-pharmacophore modelling, molecular docking, molecular dynamics and quantum mechanics studies
por: Alzain, Abdulrahim A., et al.
Publicado: (2021)

The TMPRSS2 Inhibitor Nafamostat Reduces SARS-CoV-2 Pulmonary Infection in Mouse Models of COVID-19
por: Li, Kun, et al.
Publicado: (2021)

ACE2 and TMPRSS2 Immunolocalization and COVID-19-Related Thyroid Disorder
por: Park, Gi-Cheol, et al.
Publicado: (2022)

Association of the Transmembrane Serine Protease-2 (TMPRSS2) Polymorphisms with COVID-19
por: Posadas-Sánchez, Rosalinda, et al.
Publicado: (2022)

Consideration on TMPRSS2 and the risk of COVID-19 infection in Cushing’s syndrome
por: Barbot, Mattia, et al.
Publicado: (2020)

Identification of novel TMPRSS2 inhibitors against SARS-CoV-2 infection: a structure-based virtual screening and molecular dynamics study
por: Manandhar, Suman, et al.
Publicado: (2022)

Gastrointestinal cancers, ACE-2/TMPRSS2 expression and susceptibility to COVID-19
por: Shafiee, Sepehr, et al.
Publicado: (2021)

Identification of 13 Guanidinobenzoyl- or Aminidinobenzoyl-Containing Drugs to Potentially Inhibit TMPRSS2 for COVID-19 Treatment
por: Huang, Xiaoqiang, et al.
Publicado: (2021)

A variant in TMPRSS2 is associated with decreased disease severity in COVID-19
por: Ravikanth, Vishnubhotla, et al.
Publicado: (2021)

Virtual screening and in silico design of novel inhibitors of bacterial lectins
por: Alán, Jan, et al.
Publicado: (2012)

TMPRSS2 polymorphism (rs12329760) and the severity of the COVID-19 in Iranian population
por: Yaghoobi, Arash, et al.
Publicado: (2023)

In Silico Molecular Characterization of Human TMPRSS2 Protease Polymorphic Variants and Associated SARS-CoV-2 Susceptibility
por: Salleh, Mohd Zulkifli, et al.
Publicado: (2022)

Identification of Novel Hypothalamic MicroRNAs as Promising Therapeutics for SARS-CoV-2 by Regulating ACE2 and TMPRSS2 Expression: An In Silico Analysis
por: Mukhopadhyay, Debasmita, et al.
Publicado: (2020)

TMPRSS2 and TMPRSS4 promote SARS-CoV-2 infection of human small intestinal enterocytes
por: Zang, Ruochen, et al.
Publicado: (2020)

Novel Natural Inhibitors of CYP1A2 Identified by in Silico and in Vitro Screening
por: Zhu, Ruixin, et al.
Publicado: (2011)

TMPRSS2 activity may mediate sex differences in COVID-19 severity
por: Okwan-Duodu, Derick, et al.
Publicado: (2021)

An In-silico Screening Strategy to the Prediction of New Inhibitors of COVID-19 M(pro) Protein
por: Abbasi, Maryam, et al.
Publicado: (2021)

ACE2, TMPRSS2 distribution and extrapulmonary organ injury in patients with COVID-19
por: Dong, Mengzhen, et al.
Publicado: (2020)

COVID-19 and the male susceptibility: the role of ACE2, TMPRSS2 and the androgen receptor
por: Mjaess, G., et al.
Publicado: (2020)

Efficacy of the TMPRSS2 inhibitor camostat mesilate in patients hospitalized with Covid-19-a double-blind randomized controlled trial.
por: Gunst, Jesper D., et al.
Publicado: (2021)

Association between ACE2 and TMPRSS2 nasopharyngeal expression and COVID-19 respiratory distress
por: Rossi, Átila Duque, et al.
Publicado: (2021)

Polymorphisms and mutations of ACE2 and TMPRSS2 genes are associated with COVID-19: a systematic review
por: Li, Jingwei, et al.
Publicado: (2022)

High expression of ACE2 and TMPRSS2 and clinical characteristics of COVID-19 in colorectal cancer patients
por: Liu, Chao, et al.
Publicado: (2021)

Quantitative Expression of TMPRSS2 Transcript in Prostate Tumor Cells Reflects TMPRSS2-ERG Fusion Status
por: Mwamukonda, Kuwong, et al.
Publicado: (2009)

RAndomized Clinical Trial Of NAfamostat Mesylate, A Potent Transmembrane Protease Serine 2 (TMPRSS2) Inhibitor, in Patients with COVID-19 Pneumonia
por: Seccia, Teresa Maria, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_30ni31npb2ui58o443nldl1u91