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Integration of Ligand-Based and Structure-Based Methods for the Design of Small-Molecule TLR7 Antagonists

Toll-like receptor 7 (TLR7) is activated in response to the binding of single-stranded RNA. Its over-activation has been implicated in several autoimmune disorders, and thus, it is an established therapeutic target in such circumstances. TLR7 small-molecule antagonists are not yet available for ther...

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Detalles Bibliográficos
Autores principales:	Pal, Sourav, Ghosh Dastidar, Uddipta, Ghosh, Trisha, Ganguly, Dipyaman, Talukdar, Arindam
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9268101/ https://www.ncbi.nlm.nih.gov/pubmed/35807273 http://dx.doi.org/10.3390/molecules27134026

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