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Conversion of the Native N-Terminal Domain of TDP-43 into a Monomeric Alternative Fold with Lower Aggregation Propensity

TAR DNA-binding protein 43 (TDP-43) forms intraneuronal cytoplasmic inclusions associated with amyotrophic lateral sclerosis and ubiquitin-positive frontotemporal lobar degeneration. Its N-terminal domain (NTD) can dimerise/oligomerise with the head-to-tail arrangement, which is essential for functi...

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Detalles Bibliográficos
Autores principales:	Moretti, Matteo, Marzi, Isabella, Cantarutti, Cristina, Vivoli Vega, Mirella, Mandaliti, Walter, Mimmi, Maria Chiara, Bemporad, Francesco, Corazza, Alessandra, Chiti, Fabrizio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9268139/ https://www.ncbi.nlm.nih.gov/pubmed/35807552 http://dx.doi.org/10.3390/molecules27134309

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