Naphthalene Diimides Carrying Two β-Cyclodextrins Prefer Telomere RNA G-Quadruplex Recognition

Newly synthesized naphthalene diimide carrying two β-cyclodextrins (NDI-β-CyDs) showed improved specificity for the parallel G-quadruplex structure alongside the hybrid G-quadruplex structure. Specifically, the highest binding affinity of NDI-β-CyDs for the telomere RNA G-quadruplex was observed. Th...

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Detalles Bibliográficos
Autores principales: Zou, Tingting, Sato, Yuka, Kaneyoshi, Shuma, Mano, Kota, Yasukawa, Rui, Nakano, Yoshifumi, Fujii, Satoshi, Sato, Shinobu, Takenaka, Shigeori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9268153/
https://www.ncbi.nlm.nih.gov/pubmed/35807292
http://dx.doi.org/10.3390/molecules27134053
Descripción
Sumario:Newly synthesized naphthalene diimide carrying two β-cyclodextrins (NDI-β-CyDs) showed improved specificity for the parallel G-quadruplex structure alongside the hybrid G-quadruplex structure. Specifically, the highest binding affinity of NDI-β-CyDs for the telomere RNA G-quadruplex was observed. The binding simulation indicated that β-cyclodextrins might be available for loop nucleobase inclusion under its complex.

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