Synthesis and Characterization of Tetracycline Loaded Methionine-Coated NiFe(2)O(4) Nanoparticles for Anticancer and Antibacterial Applications

In the present study, nickel ferrite (NiFe(2)O(4))-based smart magnetic nanoparticles were fabricated and coated with methionine. Physiochemical characterization of the obtained Met-NiFe(2)O(4) nanoparticles revealed the presence of methionine coating over the nanoparticle surface. Drug release study indicated that Tet-Met-NiFe(2)O(4) nanoparticles possess pH-responsive controlled drug release behavior for tetracycline (Tet). The drug loading content for Tet was found to be 0.27 mg/L of nanoparticles. In vitro cytotoxicity test showed that the Met-NiFe(2)O(4) nanoparticles is biocompatible. Moreover, this magnetic nanostructured material shown strong anticancer property as these nanomaterials significantly reduced the viability of A375 cells when compared to free Tet solution. In addition, Tet-Met-NiFe(2)O(4) nanoparticles also showed strong antibacterial activity against different bacterial pathogens.