Cargando…

Self-Assembled Nanoscale Materials for Neuronal Regeneration: A Focus on BDNF Protein and Nucleic Acid Biotherapeutic Delivery

Enabling challenging applications of nanomedicine and precision medicine in the treatment of neurodegenerative disorders requires deeper investigations of nanocarrier-mediated biomolecular delivery for neuronal targeting and recovery. The successful use of macromolecular biotherapeutics (recombinant...

Descripción completa

Detalles Bibliográficos
Autores principales: Wu, Yu, Rakotoarisoa, Miora, Angelov, Borislav, Deng, Yuru, Angelova, Angelina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9268293/
https://www.ncbi.nlm.nih.gov/pubmed/35808102
http://dx.doi.org/10.3390/nano12132267
_version_ 1784743942647971840
author Wu, Yu
Rakotoarisoa, Miora
Angelov, Borislav
Deng, Yuru
Angelova, Angelina
author_facet Wu, Yu
Rakotoarisoa, Miora
Angelov, Borislav
Deng, Yuru
Angelova, Angelina
author_sort Wu, Yu
collection PubMed
description Enabling challenging applications of nanomedicine and precision medicine in the treatment of neurodegenerative disorders requires deeper investigations of nanocarrier-mediated biomolecular delivery for neuronal targeting and recovery. The successful use of macromolecular biotherapeutics (recombinant growth factors, antibodies, enzymes, synthetic peptides, cell-penetrating peptide–drug conjugates, and RNAi sequences) in clinical developments for neuronal regeneration should benefit from the recent strategies for enhancement of their bioavailability. We highlight the advances in the development of nanoscale materials for drug delivery in neurodegenerative disorders. The emphasis is placed on nanoformulations for the delivery of brain-derived neurotrophic factor (BDNF) using different types of lipidic nanocarriers (liposomes, liquid crystalline or solid lipid nanoparticles) and polymer-based scaffolds, nanofibers and hydrogels. Self-assembled soft-matter nanoscale materials show favorable neuroprotective characteristics, safety, and efficacy profiles in drug delivery to the central and peripheral nervous systems. The advances summarized here indicate that neuroprotective biomolecule-loaded nanoparticles and injectable hydrogels can improve neuronal survival and reduce tissue injury. Certain recently reported neuronal dysfunctions in long-COVID-19 survivors represent early manifestations of neurodegenerative pathologies. Therefore, BDNF delivery systems may also help in prospective studies on recovery from long-term COVID-19 neurological complications and be considered as promising systems for personalized treatment of neuronal dysfunctions and prevention or retarding of neurodegenerative disorders.
format Online
Article
Text
id pubmed-9268293
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-92682932022-07-09 Self-Assembled Nanoscale Materials for Neuronal Regeneration: A Focus on BDNF Protein and Nucleic Acid Biotherapeutic Delivery Wu, Yu Rakotoarisoa, Miora Angelov, Borislav Deng, Yuru Angelova, Angelina Nanomaterials (Basel) Review Enabling challenging applications of nanomedicine and precision medicine in the treatment of neurodegenerative disorders requires deeper investigations of nanocarrier-mediated biomolecular delivery for neuronal targeting and recovery. The successful use of macromolecular biotherapeutics (recombinant growth factors, antibodies, enzymes, synthetic peptides, cell-penetrating peptide–drug conjugates, and RNAi sequences) in clinical developments for neuronal regeneration should benefit from the recent strategies for enhancement of their bioavailability. We highlight the advances in the development of nanoscale materials for drug delivery in neurodegenerative disorders. The emphasis is placed on nanoformulations for the delivery of brain-derived neurotrophic factor (BDNF) using different types of lipidic nanocarriers (liposomes, liquid crystalline or solid lipid nanoparticles) and polymer-based scaffolds, nanofibers and hydrogels. Self-assembled soft-matter nanoscale materials show favorable neuroprotective characteristics, safety, and efficacy profiles in drug delivery to the central and peripheral nervous systems. The advances summarized here indicate that neuroprotective biomolecule-loaded nanoparticles and injectable hydrogels can improve neuronal survival and reduce tissue injury. Certain recently reported neuronal dysfunctions in long-COVID-19 survivors represent early manifestations of neurodegenerative pathologies. Therefore, BDNF delivery systems may also help in prospective studies on recovery from long-term COVID-19 neurological complications and be considered as promising systems for personalized treatment of neuronal dysfunctions and prevention or retarding of neurodegenerative disorders. MDPI 2022-06-30 /pmc/articles/PMC9268293/ /pubmed/35808102 http://dx.doi.org/10.3390/nano12132267 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Wu, Yu
Rakotoarisoa, Miora
Angelov, Borislav
Deng, Yuru
Angelova, Angelina
Self-Assembled Nanoscale Materials for Neuronal Regeneration: A Focus on BDNF Protein and Nucleic Acid Biotherapeutic Delivery
title Self-Assembled Nanoscale Materials for Neuronal Regeneration: A Focus on BDNF Protein and Nucleic Acid Biotherapeutic Delivery
title_full Self-Assembled Nanoscale Materials for Neuronal Regeneration: A Focus on BDNF Protein and Nucleic Acid Biotherapeutic Delivery
title_fullStr Self-Assembled Nanoscale Materials for Neuronal Regeneration: A Focus on BDNF Protein and Nucleic Acid Biotherapeutic Delivery
title_full_unstemmed Self-Assembled Nanoscale Materials for Neuronal Regeneration: A Focus on BDNF Protein and Nucleic Acid Biotherapeutic Delivery
title_short Self-Assembled Nanoscale Materials for Neuronal Regeneration: A Focus on BDNF Protein and Nucleic Acid Biotherapeutic Delivery
title_sort self-assembled nanoscale materials for neuronal regeneration: a focus on bdnf protein and nucleic acid biotherapeutic delivery
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9268293/
https://www.ncbi.nlm.nih.gov/pubmed/35808102
http://dx.doi.org/10.3390/nano12132267
work_keys_str_mv AT wuyu selfassemblednanoscalematerialsforneuronalregenerationafocusonbdnfproteinandnucleicacidbiotherapeuticdelivery
AT rakotoarisoamiora selfassemblednanoscalematerialsforneuronalregenerationafocusonbdnfproteinandnucleicacidbiotherapeuticdelivery
AT angelovborislav selfassemblednanoscalematerialsforneuronalregenerationafocusonbdnfproteinandnucleicacidbiotherapeuticdelivery
AT dengyuru selfassemblednanoscalematerialsforneuronalregenerationafocusonbdnfproteinandnucleicacidbiotherapeuticdelivery
AT angelovaangelina selfassemblednanoscalematerialsforneuronalregenerationafocusonbdnfproteinandnucleicacidbiotherapeuticdelivery