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Factors associated with death in COVID-19 patients over 60 years of age at Kinshasa University Hospital, Democratic Republic of Congo (DRC)
INTRODUCTION: the objectives of the present study were to determine the mortality rate in patients over 60 years of age with COVID-19 and to identify risk factors. METHODS: the present historical cohort study took place at the Kinshasa University Hospital (KUH), DRC. Older patients admitted from Mar...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The African Field Epidemiology Network
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9268318/ https://www.ncbi.nlm.nih.gov/pubmed/35865854 http://dx.doi.org/10.11604/pamj.2022.41.330.32602 |
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author | Bepouka, Ben Mandina, Madone Longokolo, Murielle Mayasi, Nadine Odio, Ossam Mangala, Donat Mafuta, Yves Makulo, Jean Robert Mbula, Marcel Kayembe, Jean Marie Situakibanza, Hippolyte |
author_facet | Bepouka, Ben Mandina, Madone Longokolo, Murielle Mayasi, Nadine Odio, Ossam Mangala, Donat Mafuta, Yves Makulo, Jean Robert Mbula, Marcel Kayembe, Jean Marie Situakibanza, Hippolyte |
author_sort | Bepouka, Ben |
collection | PubMed |
description | INTRODUCTION: the objectives of the present study were to determine the mortality rate in patients over 60 years of age with COVID-19 and to identify risk factors. METHODS: the present historical cohort study took place at the Kinshasa University Hospital (KUH), DRC. Older patients admitted from March 2020 to May 2021 and diagnosed COVID-19 positive at the laboratory were selected. The relationship between clinical and biological risk factors, treatment, and in-hospital mortality was modeled using Cox regression. RESULTS: of two hundred and twenty-two patients at least 60 years old, 97 died, for a mortality rate of 43.69%. The median age was 70 years (64-74) with extremes of 60 to 88 years. Low oxygen saturation of < 90% (aHR 1.69; 95% CI [1.03-2.77]; p=0.038) was an independent predictor of mortality. The risk of death was reduced with corticosteroid use (aHR 0.54; 95% CI [0.40-0.75]; p=0.01) and anticoagulant treatment (aHR 0.53; 95% CI [0.38-0.73]; p=0.01). CONCLUSION: mortality was high in seniors during COVID-19 and low oxygen saturation on admission was a risk factor for mortality. Corticosteroid therapy and anticoagulation were protective factors. These should be considered in management to reduce mortality. |
format | Online Article Text |
id | pubmed-9268318 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | The African Field Epidemiology Network |
record_format | MEDLINE/PubMed |
spelling | pubmed-92683182022-07-20 Factors associated with death in COVID-19 patients over 60 years of age at Kinshasa University Hospital, Democratic Republic of Congo (DRC) Bepouka, Ben Mandina, Madone Longokolo, Murielle Mayasi, Nadine Odio, Ossam Mangala, Donat Mafuta, Yves Makulo, Jean Robert Mbula, Marcel Kayembe, Jean Marie Situakibanza, Hippolyte Pan Afr Med J Research INTRODUCTION: the objectives of the present study were to determine the mortality rate in patients over 60 years of age with COVID-19 and to identify risk factors. METHODS: the present historical cohort study took place at the Kinshasa University Hospital (KUH), DRC. Older patients admitted from March 2020 to May 2021 and diagnosed COVID-19 positive at the laboratory were selected. The relationship between clinical and biological risk factors, treatment, and in-hospital mortality was modeled using Cox regression. RESULTS: of two hundred and twenty-two patients at least 60 years old, 97 died, for a mortality rate of 43.69%. The median age was 70 years (64-74) with extremes of 60 to 88 years. Low oxygen saturation of < 90% (aHR 1.69; 95% CI [1.03-2.77]; p=0.038) was an independent predictor of mortality. The risk of death was reduced with corticosteroid use (aHR 0.54; 95% CI [0.40-0.75]; p=0.01) and anticoagulant treatment (aHR 0.53; 95% CI [0.38-0.73]; p=0.01). CONCLUSION: mortality was high in seniors during COVID-19 and low oxygen saturation on admission was a risk factor for mortality. Corticosteroid therapy and anticoagulation were protective factors. These should be considered in management to reduce mortality. The African Field Epidemiology Network 2022-04-22 /pmc/articles/PMC9268318/ /pubmed/35865854 http://dx.doi.org/10.11604/pamj.2022.41.330.32602 Text en Copyright: Ben Bepouka et al. https://creativecommons.org/licenses/by/4.0/The Pan African Medical Journal (ISSN: 1937-8688). This is an Open Access article distributed under the terms of the Creative Commons Attribution International 4.0 License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Bepouka, Ben Mandina, Madone Longokolo, Murielle Mayasi, Nadine Odio, Ossam Mangala, Donat Mafuta, Yves Makulo, Jean Robert Mbula, Marcel Kayembe, Jean Marie Situakibanza, Hippolyte Factors associated with death in COVID-19 patients over 60 years of age at Kinshasa University Hospital, Democratic Republic of Congo (DRC) |
title | Factors associated with death in COVID-19 patients over 60 years of age at Kinshasa University Hospital, Democratic Republic of Congo (DRC) |
title_full | Factors associated with death in COVID-19 patients over 60 years of age at Kinshasa University Hospital, Democratic Republic of Congo (DRC) |
title_fullStr | Factors associated with death in COVID-19 patients over 60 years of age at Kinshasa University Hospital, Democratic Republic of Congo (DRC) |
title_full_unstemmed | Factors associated with death in COVID-19 patients over 60 years of age at Kinshasa University Hospital, Democratic Republic of Congo (DRC) |
title_short | Factors associated with death in COVID-19 patients over 60 years of age at Kinshasa University Hospital, Democratic Republic of Congo (DRC) |
title_sort | factors associated with death in covid-19 patients over 60 years of age at kinshasa university hospital, democratic republic of congo (drc) |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9268318/ https://www.ncbi.nlm.nih.gov/pubmed/35865854 http://dx.doi.org/10.11604/pamj.2022.41.330.32602 |
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