Cargando…

Factors associated with death in COVID-19 patients over 60 years of age at Kinshasa University Hospital, Democratic Republic of Congo (DRC)

INTRODUCTION: the objectives of the present study were to determine the mortality rate in patients over 60 years of age with COVID-19 and to identify risk factors. METHODS: the present historical cohort study took place at the Kinshasa University Hospital (KUH), DRC. Older patients admitted from Mar...

Descripción completa

Detalles Bibliográficos
Autores principales: Bepouka, Ben, Mandina, Madone, Longokolo, Murielle, Mayasi, Nadine, Odio, Ossam, Mangala, Donat, Mafuta, Yves, Makulo, Jean Robert, Mbula, Marcel, Kayembe, Jean Marie, Situakibanza, Hippolyte
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The African Field Epidemiology Network 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9268318/
https://www.ncbi.nlm.nih.gov/pubmed/35865854
http://dx.doi.org/10.11604/pamj.2022.41.330.32602
_version_ 1784743949508804608
author Bepouka, Ben
Mandina, Madone
Longokolo, Murielle
Mayasi, Nadine
Odio, Ossam
Mangala, Donat
Mafuta, Yves
Makulo, Jean Robert
Mbula, Marcel
Kayembe, Jean Marie
Situakibanza, Hippolyte
author_facet Bepouka, Ben
Mandina, Madone
Longokolo, Murielle
Mayasi, Nadine
Odio, Ossam
Mangala, Donat
Mafuta, Yves
Makulo, Jean Robert
Mbula, Marcel
Kayembe, Jean Marie
Situakibanza, Hippolyte
author_sort Bepouka, Ben
collection PubMed
description INTRODUCTION: the objectives of the present study were to determine the mortality rate in patients over 60 years of age with COVID-19 and to identify risk factors. METHODS: the present historical cohort study took place at the Kinshasa University Hospital (KUH), DRC. Older patients admitted from March 2020 to May 2021 and diagnosed COVID-19 positive at the laboratory were selected. The relationship between clinical and biological risk factors, treatment, and in-hospital mortality was modeled using Cox regression. RESULTS: of two hundred and twenty-two patients at least 60 years old, 97 died, for a mortality rate of 43.69%. The median age was 70 years (64-74) with extremes of 60 to 88 years. Low oxygen saturation of < 90% (aHR 1.69; 95% CI [1.03-2.77]; p=0.038) was an independent predictor of mortality. The risk of death was reduced with corticosteroid use (aHR 0.54; 95% CI [0.40-0.75]; p=0.01) and anticoagulant treatment (aHR 0.53; 95% CI [0.38-0.73]; p=0.01). CONCLUSION: mortality was high in seniors during COVID-19 and low oxygen saturation on admission was a risk factor for mortality. Corticosteroid therapy and anticoagulation were protective factors. These should be considered in management to reduce mortality.
format Online
Article
Text
id pubmed-9268318
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher The African Field Epidemiology Network
record_format MEDLINE/PubMed
spelling pubmed-92683182022-07-20 Factors associated with death in COVID-19 patients over 60 years of age at Kinshasa University Hospital, Democratic Republic of Congo (DRC) Bepouka, Ben Mandina, Madone Longokolo, Murielle Mayasi, Nadine Odio, Ossam Mangala, Donat Mafuta, Yves Makulo, Jean Robert Mbula, Marcel Kayembe, Jean Marie Situakibanza, Hippolyte Pan Afr Med J Research INTRODUCTION: the objectives of the present study were to determine the mortality rate in patients over 60 years of age with COVID-19 and to identify risk factors. METHODS: the present historical cohort study took place at the Kinshasa University Hospital (KUH), DRC. Older patients admitted from March 2020 to May 2021 and diagnosed COVID-19 positive at the laboratory were selected. The relationship between clinical and biological risk factors, treatment, and in-hospital mortality was modeled using Cox regression. RESULTS: of two hundred and twenty-two patients at least 60 years old, 97 died, for a mortality rate of 43.69%. The median age was 70 years (64-74) with extremes of 60 to 88 years. Low oxygen saturation of < 90% (aHR 1.69; 95% CI [1.03-2.77]; p=0.038) was an independent predictor of mortality. The risk of death was reduced with corticosteroid use (aHR 0.54; 95% CI [0.40-0.75]; p=0.01) and anticoagulant treatment (aHR 0.53; 95% CI [0.38-0.73]; p=0.01). CONCLUSION: mortality was high in seniors during COVID-19 and low oxygen saturation on admission was a risk factor for mortality. Corticosteroid therapy and anticoagulation were protective factors. These should be considered in management to reduce mortality. The African Field Epidemiology Network 2022-04-22 /pmc/articles/PMC9268318/ /pubmed/35865854 http://dx.doi.org/10.11604/pamj.2022.41.330.32602 Text en Copyright: Ben Bepouka et al. https://creativecommons.org/licenses/by/4.0/The Pan African Medical Journal (ISSN: 1937-8688). This is an Open Access article distributed under the terms of the Creative Commons Attribution International 4.0 License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Bepouka, Ben
Mandina, Madone
Longokolo, Murielle
Mayasi, Nadine
Odio, Ossam
Mangala, Donat
Mafuta, Yves
Makulo, Jean Robert
Mbula, Marcel
Kayembe, Jean Marie
Situakibanza, Hippolyte
Factors associated with death in COVID-19 patients over 60 years of age at Kinshasa University Hospital, Democratic Republic of Congo (DRC)
title Factors associated with death in COVID-19 patients over 60 years of age at Kinshasa University Hospital, Democratic Republic of Congo (DRC)
title_full Factors associated with death in COVID-19 patients over 60 years of age at Kinshasa University Hospital, Democratic Republic of Congo (DRC)
title_fullStr Factors associated with death in COVID-19 patients over 60 years of age at Kinshasa University Hospital, Democratic Republic of Congo (DRC)
title_full_unstemmed Factors associated with death in COVID-19 patients over 60 years of age at Kinshasa University Hospital, Democratic Republic of Congo (DRC)
title_short Factors associated with death in COVID-19 patients over 60 years of age at Kinshasa University Hospital, Democratic Republic of Congo (DRC)
title_sort factors associated with death in covid-19 patients over 60 years of age at kinshasa university hospital, democratic republic of congo (drc)
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9268318/
https://www.ncbi.nlm.nih.gov/pubmed/35865854
http://dx.doi.org/10.11604/pamj.2022.41.330.32602
work_keys_str_mv AT bepoukaben factorsassociatedwithdeathincovid19patientsover60yearsofageatkinshasauniversityhospitaldemocraticrepublicofcongodrc
AT mandinamadone factorsassociatedwithdeathincovid19patientsover60yearsofageatkinshasauniversityhospitaldemocraticrepublicofcongodrc
AT longokolomurielle factorsassociatedwithdeathincovid19patientsover60yearsofageatkinshasauniversityhospitaldemocraticrepublicofcongodrc
AT mayasinadine factorsassociatedwithdeathincovid19patientsover60yearsofageatkinshasauniversityhospitaldemocraticrepublicofcongodrc
AT odioossam factorsassociatedwithdeathincovid19patientsover60yearsofageatkinshasauniversityhospitaldemocraticrepublicofcongodrc
AT mangaladonat factorsassociatedwithdeathincovid19patientsover60yearsofageatkinshasauniversityhospitaldemocraticrepublicofcongodrc
AT mafutayves factorsassociatedwithdeathincovid19patientsover60yearsofageatkinshasauniversityhospitaldemocraticrepublicofcongodrc
AT makulojeanrobert factorsassociatedwithdeathincovid19patientsover60yearsofageatkinshasauniversityhospitaldemocraticrepublicofcongodrc
AT mbulamarcel factorsassociatedwithdeathincovid19patientsover60yearsofageatkinshasauniversityhospitaldemocraticrepublicofcongodrc
AT kayembejeanmarie factorsassociatedwithdeathincovid19patientsover60yearsofageatkinshasauniversityhospitaldemocraticrepublicofcongodrc
AT situakibanzahippolyte factorsassociatedwithdeathincovid19patientsover60yearsofageatkinshasauniversityhospitaldemocraticrepublicofcongodrc