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The Associations of Selenoprotein Genetic Variants with the Risks of Colorectal Adenoma and Colorectal Cancer: Case–Control Studies in Irish and Czech Populations

Background: Selenium manifests its biological effects through its incorporation into selenoproteins, which play several roles in countering oxidative and inflammatory responses implicated in colorectal carcinogenesis. Selenoprotein genetic variants may contribute to colorectal cancer (CRC) developme...

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Autores principales: Mukhtar, Maryam, Ashfield, Niall, Vodickova, Ludmila, Vymetalkova, Veronika, Levy, Miroslav, Liska, Václav, Bruha, Jan, Bendova, Petra, O’Sullivan, Jacintha, Doherty, Glen, Sheahan, Kieran, Nolan, Blathnaid, Vodicka, Pavel, Hughes, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9268344/
https://www.ncbi.nlm.nih.gov/pubmed/35807897
http://dx.doi.org/10.3390/nu14132718
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author Mukhtar, Maryam
Ashfield, Niall
Vodickova, Ludmila
Vymetalkova, Veronika
Levy, Miroslav
Liska, Václav
Bruha, Jan
Bendova, Petra
O’Sullivan, Jacintha
Doherty, Glen
Sheahan, Kieran
Nolan, Blathnaid
Vodicka, Pavel
Hughes, David J.
author_facet Mukhtar, Maryam
Ashfield, Niall
Vodickova, Ludmila
Vymetalkova, Veronika
Levy, Miroslav
Liska, Václav
Bruha, Jan
Bendova, Petra
O’Sullivan, Jacintha
Doherty, Glen
Sheahan, Kieran
Nolan, Blathnaid
Vodicka, Pavel
Hughes, David J.
author_sort Mukhtar, Maryam
collection PubMed
description Background: Selenium manifests its biological effects through its incorporation into selenoproteins, which play several roles in countering oxidative and inflammatory responses implicated in colorectal carcinogenesis. Selenoprotein genetic variants may contribute to colorectal cancer (CRC) development, as we previously observed for SNP variants in a large European prospective study and a Czech case–control cohort. Methods: We tested if significantly associated selenoprotein gene SNPs from these studies were also associated with CRC risk in case–control studies from Ireland (colorectal neoplasia, i.e., cancer and adenoma cases: 450, controls: 461) and the Czech Republic (CRC cases: 718, controls: 646). Genotyping of 23 SNPs (20 in the Irish and 13 in the Czechs) was performed by competitive specific allele-specific PCR (KASPar). Multivariable adjusted logistic regression was used to assess the associations with CRC development. Results: We found significant associations with an increased CRC risk for rs5859 (SELENOF) and rs2972994 (SELENOP) in the Irish cohort but only with rs4802034 (SELENOV) in the Czechs. Significant associations were observed for rs5859 (SELENOF), rs4659382 (SELENON), rs2972994 (SELENOP), rs34713741 (SELENOS), and the related Se metabolism gene variant rs2275129 (SEPHS1) with advanced colorectal neoplasia development. However, none of these findings retained significance after multiple testing corrections. Conclusions: Several SNPs previously associated with CRC risk were also associated with CRC or colorectal neoplasia development in either the Irish or Czech cohorts. Selenoprotein gene variation may modify CRC risk across diverse European populations, although the specific variants may differ.
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spelling pubmed-92683442022-07-09 The Associations of Selenoprotein Genetic Variants with the Risks of Colorectal Adenoma and Colorectal Cancer: Case–Control Studies in Irish and Czech Populations Mukhtar, Maryam Ashfield, Niall Vodickova, Ludmila Vymetalkova, Veronika Levy, Miroslav Liska, Václav Bruha, Jan Bendova, Petra O’Sullivan, Jacintha Doherty, Glen Sheahan, Kieran Nolan, Blathnaid Vodicka, Pavel Hughes, David J. Nutrients Article Background: Selenium manifests its biological effects through its incorporation into selenoproteins, which play several roles in countering oxidative and inflammatory responses implicated in colorectal carcinogenesis. Selenoprotein genetic variants may contribute to colorectal cancer (CRC) development, as we previously observed for SNP variants in a large European prospective study and a Czech case–control cohort. Methods: We tested if significantly associated selenoprotein gene SNPs from these studies were also associated with CRC risk in case–control studies from Ireland (colorectal neoplasia, i.e., cancer and adenoma cases: 450, controls: 461) and the Czech Republic (CRC cases: 718, controls: 646). Genotyping of 23 SNPs (20 in the Irish and 13 in the Czechs) was performed by competitive specific allele-specific PCR (KASPar). Multivariable adjusted logistic regression was used to assess the associations with CRC development. Results: We found significant associations with an increased CRC risk for rs5859 (SELENOF) and rs2972994 (SELENOP) in the Irish cohort but only with rs4802034 (SELENOV) in the Czechs. Significant associations were observed for rs5859 (SELENOF), rs4659382 (SELENON), rs2972994 (SELENOP), rs34713741 (SELENOS), and the related Se metabolism gene variant rs2275129 (SEPHS1) with advanced colorectal neoplasia development. However, none of these findings retained significance after multiple testing corrections. Conclusions: Several SNPs previously associated with CRC risk were also associated with CRC or colorectal neoplasia development in either the Irish or Czech cohorts. Selenoprotein gene variation may modify CRC risk across diverse European populations, although the specific variants may differ. MDPI 2022-06-29 /pmc/articles/PMC9268344/ /pubmed/35807897 http://dx.doi.org/10.3390/nu14132718 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Mukhtar, Maryam
Ashfield, Niall
Vodickova, Ludmila
Vymetalkova, Veronika
Levy, Miroslav
Liska, Václav
Bruha, Jan
Bendova, Petra
O’Sullivan, Jacintha
Doherty, Glen
Sheahan, Kieran
Nolan, Blathnaid
Vodicka, Pavel
Hughes, David J.
The Associations of Selenoprotein Genetic Variants with the Risks of Colorectal Adenoma and Colorectal Cancer: Case–Control Studies in Irish and Czech Populations
title The Associations of Selenoprotein Genetic Variants with the Risks of Colorectal Adenoma and Colorectal Cancer: Case–Control Studies in Irish and Czech Populations
title_full The Associations of Selenoprotein Genetic Variants with the Risks of Colorectal Adenoma and Colorectal Cancer: Case–Control Studies in Irish and Czech Populations
title_fullStr The Associations of Selenoprotein Genetic Variants with the Risks of Colorectal Adenoma and Colorectal Cancer: Case–Control Studies in Irish and Czech Populations
title_full_unstemmed The Associations of Selenoprotein Genetic Variants with the Risks of Colorectal Adenoma and Colorectal Cancer: Case–Control Studies in Irish and Czech Populations
title_short The Associations of Selenoprotein Genetic Variants with the Risks of Colorectal Adenoma and Colorectal Cancer: Case–Control Studies in Irish and Czech Populations
title_sort associations of selenoprotein genetic variants with the risks of colorectal adenoma and colorectal cancer: case–control studies in irish and czech populations
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9268344/
https://www.ncbi.nlm.nih.gov/pubmed/35807897
http://dx.doi.org/10.3390/nu14132718
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