Screening an In-House Isoquinoline Alkaloids Library for New Blockers of Voltage-Gated Na(+) Channels Using Voltage Sensor Fluorescent Probes: Hits and Biases

Voltage-gated Na(+) (Na(V)) channels are significant therapeutic targets for the treatment of cardiac and neurological disorders, thus promoting the search for novel Na(V) channel ligands. With the objective of discovering new blockers of Na(V) channel ligands, we screened an In-House vegetal alkalo...

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Detalles Bibliográficos
Autores principales: Coquerel, Quentin, Legendre, Claire, Frangieh, Jacinthe, Waard, Stephan De, Montnach, Jérôme, Cmarko, Leos, Khoury, Joseph, Hassane, Charifat Said, Bréard, Dimitri, Siegler, Benjamin, Fajloun, Ziad, De Pomyers, Harold, Mabrouk, Kamel, Weiss, Norbert, Henrion, Daniel, Richomme, Pascal, Mattei, César, Waard, Michel De, Le Ray, Anne-Marie, Legros, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9268414/
https://www.ncbi.nlm.nih.gov/pubmed/35807390
http://dx.doi.org/10.3390/molecules27134133

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