Liposomal Form of 2,4-Dinitrophenol Lipophilic Derivatives as a Promising Therapeutic Agent for ATP Synthesis Inhibition

Mitochondrial uncoupler 2,4-dinitrophenol (2,4-DNP) is a promising antidiabetic and antiobesity agent. Its clinical use is limited by a narrow dynamic range and accumulation in non-target sensitive organs, which results in whole-body toxicity. A liposomal formulation could enable the mentioned drawb...

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Detalles Bibliográficos
Autores principales: Vlasova, Kseniya Yu., Ostroverkhov, Petr, Vedenyapina, Daria, Yakimova, Tamara, Trusova, Alla, Lomakina, Galina Yurievna, Vodopyanov, Stepan Sergeevich, Grin, Mikhail, Klyachko, Natalia, Chekhonin, Vladimir, Abakumov, Maxim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9268429/
https://www.ncbi.nlm.nih.gov/pubmed/35808003
http://dx.doi.org/10.3390/nano12132162

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9268429/
https://www.ncbi.nlm.nih.gov/pubmed/35808003
http://dx.doi.org/10.3390/nano12132162

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