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Vitamin D and Risk of Obesity-Related Cancers: Results from the SUN (‘Seguimiento Universidad de Navarra’) Project
Obesity is associated with a higher risk of several types of cancer, grouped as obesity-related cancers (ORC). Vitamin D deficiency is more prevalent in obese subjects, and it has been suggested to play a role in the association between obesity and cancer risk. The aim of the study was to analyze th...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9268452/ https://www.ncbi.nlm.nih.gov/pubmed/35807746 http://dx.doi.org/10.3390/nu14132561 |
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author | Sánchez-Bayona, Rodrigo Bes-Rastrollo, Maira Fernández-Lázaro, Cesar I. Bastyr, Maite Madariaga, Ainhoa Pons, Juan J. Martínez-González, Miguel A. Toledo, Estefanía |
author_facet | Sánchez-Bayona, Rodrigo Bes-Rastrollo, Maira Fernández-Lázaro, Cesar I. Bastyr, Maite Madariaga, Ainhoa Pons, Juan J. Martínez-González, Miguel A. Toledo, Estefanía |
author_sort | Sánchez-Bayona, Rodrigo |
collection | PubMed |
description | Obesity is associated with a higher risk of several types of cancer, grouped as obesity-related cancers (ORC). Vitamin D deficiency is more prevalent in obese subjects, and it has been suggested to play a role in the association between obesity and cancer risk. The aim of the study was to analyze the association between vitamin D intake and the subsequent risk of ORC in a prospective Spanish cohort of university graduates. The SUN Project, initiated in 1999, is a prospective dynamic multipurpose cohort. Participants answered a 556-item lifestyle baseline questionnaire that included a validated food-frequency questionnaire. We performed Cox regression models to estimate the hazard ratios (HRs) of ORC according to quartiles of energy-adjusted vitamin D intake (diet and supplements). We included 18,017 participants (mean age = 38 years, SD = 12 years), with a median follow-up of 12 years. Among 206,783 person-years of follow-up, we identified 225 cases of ORC. We found no significant associations between vitamin D intake and ORC risk after adjusting for potential confounders: HR(Q2vsQ1) = 1.19 (95% CI 0.81–1.75), HR(Q3vsQ1) = 1.20 (95% CI 0.81–1.78), and HR(Q4vsQ1) = 1.02 (95% CI 0.69–1.51). Dietary and supplemented vitamin D do not seem to be associated with ORC prevention in the middle-aged Spanish population. |
format | Online Article Text |
id | pubmed-9268452 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-92684522022-07-09 Vitamin D and Risk of Obesity-Related Cancers: Results from the SUN (‘Seguimiento Universidad de Navarra’) Project Sánchez-Bayona, Rodrigo Bes-Rastrollo, Maira Fernández-Lázaro, Cesar I. Bastyr, Maite Madariaga, Ainhoa Pons, Juan J. Martínez-González, Miguel A. Toledo, Estefanía Nutrients Article Obesity is associated with a higher risk of several types of cancer, grouped as obesity-related cancers (ORC). Vitamin D deficiency is more prevalent in obese subjects, and it has been suggested to play a role in the association between obesity and cancer risk. The aim of the study was to analyze the association between vitamin D intake and the subsequent risk of ORC in a prospective Spanish cohort of university graduates. The SUN Project, initiated in 1999, is a prospective dynamic multipurpose cohort. Participants answered a 556-item lifestyle baseline questionnaire that included a validated food-frequency questionnaire. We performed Cox regression models to estimate the hazard ratios (HRs) of ORC according to quartiles of energy-adjusted vitamin D intake (diet and supplements). We included 18,017 participants (mean age = 38 years, SD = 12 years), with a median follow-up of 12 years. Among 206,783 person-years of follow-up, we identified 225 cases of ORC. We found no significant associations between vitamin D intake and ORC risk after adjusting for potential confounders: HR(Q2vsQ1) = 1.19 (95% CI 0.81–1.75), HR(Q3vsQ1) = 1.20 (95% CI 0.81–1.78), and HR(Q4vsQ1) = 1.02 (95% CI 0.69–1.51). Dietary and supplemented vitamin D do not seem to be associated with ORC prevention in the middle-aged Spanish population. MDPI 2022-06-21 /pmc/articles/PMC9268452/ /pubmed/35807746 http://dx.doi.org/10.3390/nu14132561 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Sánchez-Bayona, Rodrigo Bes-Rastrollo, Maira Fernández-Lázaro, Cesar I. Bastyr, Maite Madariaga, Ainhoa Pons, Juan J. Martínez-González, Miguel A. Toledo, Estefanía Vitamin D and Risk of Obesity-Related Cancers: Results from the SUN (‘Seguimiento Universidad de Navarra’) Project |
title | Vitamin D and Risk of Obesity-Related Cancers: Results from the SUN (‘Seguimiento Universidad de Navarra’) Project |
title_full | Vitamin D and Risk of Obesity-Related Cancers: Results from the SUN (‘Seguimiento Universidad de Navarra’) Project |
title_fullStr | Vitamin D and Risk of Obesity-Related Cancers: Results from the SUN (‘Seguimiento Universidad de Navarra’) Project |
title_full_unstemmed | Vitamin D and Risk of Obesity-Related Cancers: Results from the SUN (‘Seguimiento Universidad de Navarra’) Project |
title_short | Vitamin D and Risk of Obesity-Related Cancers: Results from the SUN (‘Seguimiento Universidad de Navarra’) Project |
title_sort | vitamin d and risk of obesity-related cancers: results from the sun (‘seguimiento universidad de navarra’) project |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9268452/ https://www.ncbi.nlm.nih.gov/pubmed/35807746 http://dx.doi.org/10.3390/nu14132561 |
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