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Novel Iron Oxide Nanoparticles Induce Ferroptosis in a Panel of Cancer Cell Lines

The use of nanomaterials rationally engineered to treat cancer is a burgeoning field that has reported great medical achievements. Iron-based polymeric nano-formulations with precisely tuned physicochemical properties are an expanding and versatile therapeutic strategy for tumor treatment. Recently,...

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Detalles Bibliográficos
Autores principales: Fernández-Acosta, Roberto, Iriarte-Mesa, Claudia, Alvarez-Alminaque, Daniel, Hassannia, Behrouz, Wiernicki, Bartosz, Díaz-García, Alicia M., Vandenabeele, Peter, Vanden Berghe, Tom, Pardo Andreu, Gilberto L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9268471/
https://www.ncbi.nlm.nih.gov/pubmed/35807217
http://dx.doi.org/10.3390/molecules27133970
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author Fernández-Acosta, Roberto
Iriarte-Mesa, Claudia
Alvarez-Alminaque, Daniel
Hassannia, Behrouz
Wiernicki, Bartosz
Díaz-García, Alicia M.
Vandenabeele, Peter
Vanden Berghe, Tom
Pardo Andreu, Gilberto L.
author_facet Fernández-Acosta, Roberto
Iriarte-Mesa, Claudia
Alvarez-Alminaque, Daniel
Hassannia, Behrouz
Wiernicki, Bartosz
Díaz-García, Alicia M.
Vandenabeele, Peter
Vanden Berghe, Tom
Pardo Andreu, Gilberto L.
author_sort Fernández-Acosta, Roberto
collection PubMed
description The use of nanomaterials rationally engineered to treat cancer is a burgeoning field that has reported great medical achievements. Iron-based polymeric nano-formulations with precisely tuned physicochemical properties are an expanding and versatile therapeutic strategy for tumor treatment. Recently, a peculiar type of regulated necrosis named ferroptosis has gained increased attention as a target for cancer therapy. Here, we show for the first time that novel iron oxide nanoparticles coated with gallic acid and polyacrylic acid (IONP–GA/PAA) possess intrinsic cytotoxic activity on various cancer cell lines. Indeed, IONP–GA/PAA treatment efficiently induces ferroptosis in glioblastoma, neuroblastoma, and fibrosarcoma cells. IONP–GA/PAA-induced ferroptosis was blocked by the canonical ferroptosis inhibitors, including deferoxamine and ciclopirox olamine (iron chelators), and ferrostatin-1, the lipophilic radical trap. These ferroptosis inhibitors also prevented the lipid hydroperoxide generation promoted by the nanoparticles. Altogether, we report on novel ferroptosis-inducing iron encapsulated nanoparticles with potent anti-cancer properties, which has promising potential for further in vivo validation.
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spelling pubmed-92684712022-07-09 Novel Iron Oxide Nanoparticles Induce Ferroptosis in a Panel of Cancer Cell Lines Fernández-Acosta, Roberto Iriarte-Mesa, Claudia Alvarez-Alminaque, Daniel Hassannia, Behrouz Wiernicki, Bartosz Díaz-García, Alicia M. Vandenabeele, Peter Vanden Berghe, Tom Pardo Andreu, Gilberto L. Molecules Article The use of nanomaterials rationally engineered to treat cancer is a burgeoning field that has reported great medical achievements. Iron-based polymeric nano-formulations with precisely tuned physicochemical properties are an expanding and versatile therapeutic strategy for tumor treatment. Recently, a peculiar type of regulated necrosis named ferroptosis has gained increased attention as a target for cancer therapy. Here, we show for the first time that novel iron oxide nanoparticles coated with gallic acid and polyacrylic acid (IONP–GA/PAA) possess intrinsic cytotoxic activity on various cancer cell lines. Indeed, IONP–GA/PAA treatment efficiently induces ferroptosis in glioblastoma, neuroblastoma, and fibrosarcoma cells. IONP–GA/PAA-induced ferroptosis was blocked by the canonical ferroptosis inhibitors, including deferoxamine and ciclopirox olamine (iron chelators), and ferrostatin-1, the lipophilic radical trap. These ferroptosis inhibitors also prevented the lipid hydroperoxide generation promoted by the nanoparticles. Altogether, we report on novel ferroptosis-inducing iron encapsulated nanoparticles with potent anti-cancer properties, which has promising potential for further in vivo validation. MDPI 2022-06-21 /pmc/articles/PMC9268471/ /pubmed/35807217 http://dx.doi.org/10.3390/molecules27133970 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Fernández-Acosta, Roberto
Iriarte-Mesa, Claudia
Alvarez-Alminaque, Daniel
Hassannia, Behrouz
Wiernicki, Bartosz
Díaz-García, Alicia M.
Vandenabeele, Peter
Vanden Berghe, Tom
Pardo Andreu, Gilberto L.
Novel Iron Oxide Nanoparticles Induce Ferroptosis in a Panel of Cancer Cell Lines
title Novel Iron Oxide Nanoparticles Induce Ferroptosis in a Panel of Cancer Cell Lines
title_full Novel Iron Oxide Nanoparticles Induce Ferroptosis in a Panel of Cancer Cell Lines
title_fullStr Novel Iron Oxide Nanoparticles Induce Ferroptosis in a Panel of Cancer Cell Lines
title_full_unstemmed Novel Iron Oxide Nanoparticles Induce Ferroptosis in a Panel of Cancer Cell Lines
title_short Novel Iron Oxide Nanoparticles Induce Ferroptosis in a Panel of Cancer Cell Lines
title_sort novel iron oxide nanoparticles induce ferroptosis in a panel of cancer cell lines
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9268471/
https://www.ncbi.nlm.nih.gov/pubmed/35807217
http://dx.doi.org/10.3390/molecules27133970
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