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Novel Iron Oxide Nanoparticles Induce Ferroptosis in a Panel of Cancer Cell Lines
The use of nanomaterials rationally engineered to treat cancer is a burgeoning field that has reported great medical achievements. Iron-based polymeric nano-formulations with precisely tuned physicochemical properties are an expanding and versatile therapeutic strategy for tumor treatment. Recently,...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9268471/ https://www.ncbi.nlm.nih.gov/pubmed/35807217 http://dx.doi.org/10.3390/molecules27133970 |
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author | Fernández-Acosta, Roberto Iriarte-Mesa, Claudia Alvarez-Alminaque, Daniel Hassannia, Behrouz Wiernicki, Bartosz Díaz-García, Alicia M. Vandenabeele, Peter Vanden Berghe, Tom Pardo Andreu, Gilberto L. |
author_facet | Fernández-Acosta, Roberto Iriarte-Mesa, Claudia Alvarez-Alminaque, Daniel Hassannia, Behrouz Wiernicki, Bartosz Díaz-García, Alicia M. Vandenabeele, Peter Vanden Berghe, Tom Pardo Andreu, Gilberto L. |
author_sort | Fernández-Acosta, Roberto |
collection | PubMed |
description | The use of nanomaterials rationally engineered to treat cancer is a burgeoning field that has reported great medical achievements. Iron-based polymeric nano-formulations with precisely tuned physicochemical properties are an expanding and versatile therapeutic strategy for tumor treatment. Recently, a peculiar type of regulated necrosis named ferroptosis has gained increased attention as a target for cancer therapy. Here, we show for the first time that novel iron oxide nanoparticles coated with gallic acid and polyacrylic acid (IONP–GA/PAA) possess intrinsic cytotoxic activity on various cancer cell lines. Indeed, IONP–GA/PAA treatment efficiently induces ferroptosis in glioblastoma, neuroblastoma, and fibrosarcoma cells. IONP–GA/PAA-induced ferroptosis was blocked by the canonical ferroptosis inhibitors, including deferoxamine and ciclopirox olamine (iron chelators), and ferrostatin-1, the lipophilic radical trap. These ferroptosis inhibitors also prevented the lipid hydroperoxide generation promoted by the nanoparticles. Altogether, we report on novel ferroptosis-inducing iron encapsulated nanoparticles with potent anti-cancer properties, which has promising potential for further in vivo validation. |
format | Online Article Text |
id | pubmed-9268471 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-92684712022-07-09 Novel Iron Oxide Nanoparticles Induce Ferroptosis in a Panel of Cancer Cell Lines Fernández-Acosta, Roberto Iriarte-Mesa, Claudia Alvarez-Alminaque, Daniel Hassannia, Behrouz Wiernicki, Bartosz Díaz-García, Alicia M. Vandenabeele, Peter Vanden Berghe, Tom Pardo Andreu, Gilberto L. Molecules Article The use of nanomaterials rationally engineered to treat cancer is a burgeoning field that has reported great medical achievements. Iron-based polymeric nano-formulations with precisely tuned physicochemical properties are an expanding and versatile therapeutic strategy for tumor treatment. Recently, a peculiar type of regulated necrosis named ferroptosis has gained increased attention as a target for cancer therapy. Here, we show for the first time that novel iron oxide nanoparticles coated with gallic acid and polyacrylic acid (IONP–GA/PAA) possess intrinsic cytotoxic activity on various cancer cell lines. Indeed, IONP–GA/PAA treatment efficiently induces ferroptosis in glioblastoma, neuroblastoma, and fibrosarcoma cells. IONP–GA/PAA-induced ferroptosis was blocked by the canonical ferroptosis inhibitors, including deferoxamine and ciclopirox olamine (iron chelators), and ferrostatin-1, the lipophilic radical trap. These ferroptosis inhibitors also prevented the lipid hydroperoxide generation promoted by the nanoparticles. Altogether, we report on novel ferroptosis-inducing iron encapsulated nanoparticles with potent anti-cancer properties, which has promising potential for further in vivo validation. MDPI 2022-06-21 /pmc/articles/PMC9268471/ /pubmed/35807217 http://dx.doi.org/10.3390/molecules27133970 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Fernández-Acosta, Roberto Iriarte-Mesa, Claudia Alvarez-Alminaque, Daniel Hassannia, Behrouz Wiernicki, Bartosz Díaz-García, Alicia M. Vandenabeele, Peter Vanden Berghe, Tom Pardo Andreu, Gilberto L. Novel Iron Oxide Nanoparticles Induce Ferroptosis in a Panel of Cancer Cell Lines |
title | Novel Iron Oxide Nanoparticles Induce Ferroptosis in a Panel of Cancer Cell Lines |
title_full | Novel Iron Oxide Nanoparticles Induce Ferroptosis in a Panel of Cancer Cell Lines |
title_fullStr | Novel Iron Oxide Nanoparticles Induce Ferroptosis in a Panel of Cancer Cell Lines |
title_full_unstemmed | Novel Iron Oxide Nanoparticles Induce Ferroptosis in a Panel of Cancer Cell Lines |
title_short | Novel Iron Oxide Nanoparticles Induce Ferroptosis in a Panel of Cancer Cell Lines |
title_sort | novel iron oxide nanoparticles induce ferroptosis in a panel of cancer cell lines |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9268471/ https://www.ncbi.nlm.nih.gov/pubmed/35807217 http://dx.doi.org/10.3390/molecules27133970 |
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