Assessing the Role of a Malonamide Linker in the Design of Potent Dual Inhibitors of Factor Xa and Cholinesterases

The rational discovery of new peptidomimetic inhibitors of the coagulation factor Xa (fXa) could help set more effective therapeutic options (to prevent atrial fibrillation). In this respect, we explored the conformational impact on the enzyme inhibition potency of the malonamide bridge, compared to...

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Detalles Bibliográficos
Autores principales: Purgatorio, Rosa, Gambacorta, Nicola, Samarelli, Francesco, Lopopolo, Gianfranco, de Candia, Modesto, Catto, Marco, Nicolotti, Orazio, Altomare, Cosimo D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9268553/
https://www.ncbi.nlm.nih.gov/pubmed/35807514
http://dx.doi.org/10.3390/molecules27134269

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9268553/
https://www.ncbi.nlm.nih.gov/pubmed/35807514
http://dx.doi.org/10.3390/molecules27134269

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