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Bio-Inspired Surface Modification of Magnetite Nanoparticles with Dopamine Conjugates
Organically-coated nanomaterials are intensively studied and find numerous applications in a wide range of areas from optics to biomedicine. One of the recent trends in material science is the application of bio-mimetic polydopamine coatings that can be produced on a variety of substrates in a cost-...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9268593/ https://www.ncbi.nlm.nih.gov/pubmed/35808066 http://dx.doi.org/10.3390/nano12132230 |
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author | Volov, Alexander Shkodenko, Liubov Koshel, Elena Drozdov, Andrey S. |
author_facet | Volov, Alexander Shkodenko, Liubov Koshel, Elena Drozdov, Andrey S. |
author_sort | Volov, Alexander |
collection | PubMed |
description | Organically-coated nanomaterials are intensively studied and find numerous applications in a wide range of areas from optics to biomedicine. One of the recent trends in material science is the application of bio-mimetic polydopamine coatings that can be produced on a variety of substrates in a cost-efficient way under mild conditions. Such coatings not only modify the biocompatibility of the material but also add functional amino groups to the surface that can be further modified by classic conjugation techniques. Here we show an alternative strategy for substrates modification using dopamine conjugates instead of native dopamine. Compared to the classic scheme, the proposed strategy allows separation of the “organic” and “colloidal” stages, and simplified identification and purification steps. Modification with pre-modified dopamine made it possible to achieve high loading capacities with active components up to 10.5% wt. A series of organo-inorganic hybrids were synthesized and their bioactivity was analyzed. |
format | Online Article Text |
id | pubmed-9268593 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-92685932022-07-09 Bio-Inspired Surface Modification of Magnetite Nanoparticles with Dopamine Conjugates Volov, Alexander Shkodenko, Liubov Koshel, Elena Drozdov, Andrey S. Nanomaterials (Basel) Article Organically-coated nanomaterials are intensively studied and find numerous applications in a wide range of areas from optics to biomedicine. One of the recent trends in material science is the application of bio-mimetic polydopamine coatings that can be produced on a variety of substrates in a cost-efficient way under mild conditions. Such coatings not only modify the biocompatibility of the material but also add functional amino groups to the surface that can be further modified by classic conjugation techniques. Here we show an alternative strategy for substrates modification using dopamine conjugates instead of native dopamine. Compared to the classic scheme, the proposed strategy allows separation of the “organic” and “colloidal” stages, and simplified identification and purification steps. Modification with pre-modified dopamine made it possible to achieve high loading capacities with active components up to 10.5% wt. A series of organo-inorganic hybrids were synthesized and their bioactivity was analyzed. MDPI 2022-06-29 /pmc/articles/PMC9268593/ /pubmed/35808066 http://dx.doi.org/10.3390/nano12132230 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Volov, Alexander Shkodenko, Liubov Koshel, Elena Drozdov, Andrey S. Bio-Inspired Surface Modification of Magnetite Nanoparticles with Dopamine Conjugates |
title | Bio-Inspired Surface Modification of Magnetite Nanoparticles with Dopamine Conjugates |
title_full | Bio-Inspired Surface Modification of Magnetite Nanoparticles with Dopamine Conjugates |
title_fullStr | Bio-Inspired Surface Modification of Magnetite Nanoparticles with Dopamine Conjugates |
title_full_unstemmed | Bio-Inspired Surface Modification of Magnetite Nanoparticles with Dopamine Conjugates |
title_short | Bio-Inspired Surface Modification of Magnetite Nanoparticles with Dopamine Conjugates |
title_sort | bio-inspired surface modification of magnetite nanoparticles with dopamine conjugates |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9268593/ https://www.ncbi.nlm.nih.gov/pubmed/35808066 http://dx.doi.org/10.3390/nano12132230 |
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