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Role of Natural Compounds and Target Enzymes in the Treatment of Alzheimer’s Disease
Alzheimer’s disease (AD) is a progressive neurological condition. The rising prevalence of AD necessitates the rapid development of efficient therapy options. Despite substantial study, only a few medications are capable of delaying the disease. Several substances with pharmacological activity, deri...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9268689/ https://www.ncbi.nlm.nih.gov/pubmed/35807418 http://dx.doi.org/10.3390/molecules27134175 |
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author | Wang, Shanshan Kong, Xianbo Chen, Zhangjing Wang, Guopin Zhang, Juan Wang, Jing |
author_facet | Wang, Shanshan Kong, Xianbo Chen, Zhangjing Wang, Guopin Zhang, Juan Wang, Jing |
author_sort | Wang, Shanshan |
collection | PubMed |
description | Alzheimer’s disease (AD) is a progressive neurological condition. The rising prevalence of AD necessitates the rapid development of efficient therapy options. Despite substantial study, only a few medications are capable of delaying the disease. Several substances with pharmacological activity, derived from plants, have been shown to have positive benefits for the treatment of AD by targeting various enzymes, such as acetylcholinesterase (AChE), butyrylcholinesterase (BuChE), β-secretase, γ-secretase, and monoamine oxidases (MAOs), which are discussed as potential targets. Medicinal plants have already contributed a number of lead molecules to medicine development, with many of them currently undergoing clinical trials. A variety of medicinal plants have been shown to diminish the degenerative symptoms associated with AD, either in their raw form or as isolated compounds. The aim of this review was to provide a brief summary of AD and its current therapies, followed by a discussion of the natural compounds examined as therapeutic agents and the processes underlying the positive effects, particularly the management of AD. |
format | Online Article Text |
id | pubmed-9268689 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-92686892022-07-09 Role of Natural Compounds and Target Enzymes in the Treatment of Alzheimer’s Disease Wang, Shanshan Kong, Xianbo Chen, Zhangjing Wang, Guopin Zhang, Juan Wang, Jing Molecules Review Alzheimer’s disease (AD) is a progressive neurological condition. The rising prevalence of AD necessitates the rapid development of efficient therapy options. Despite substantial study, only a few medications are capable of delaying the disease. Several substances with pharmacological activity, derived from plants, have been shown to have positive benefits for the treatment of AD by targeting various enzymes, such as acetylcholinesterase (AChE), butyrylcholinesterase (BuChE), β-secretase, γ-secretase, and monoamine oxidases (MAOs), which are discussed as potential targets. Medicinal plants have already contributed a number of lead molecules to medicine development, with many of them currently undergoing clinical trials. A variety of medicinal plants have been shown to diminish the degenerative symptoms associated with AD, either in their raw form or as isolated compounds. The aim of this review was to provide a brief summary of AD and its current therapies, followed by a discussion of the natural compounds examined as therapeutic agents and the processes underlying the positive effects, particularly the management of AD. MDPI 2022-06-29 /pmc/articles/PMC9268689/ /pubmed/35807418 http://dx.doi.org/10.3390/molecules27134175 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Wang, Shanshan Kong, Xianbo Chen, Zhangjing Wang, Guopin Zhang, Juan Wang, Jing Role of Natural Compounds and Target Enzymes in the Treatment of Alzheimer’s Disease |
title | Role of Natural Compounds and Target Enzymes in the Treatment of Alzheimer’s Disease |
title_full | Role of Natural Compounds and Target Enzymes in the Treatment of Alzheimer’s Disease |
title_fullStr | Role of Natural Compounds and Target Enzymes in the Treatment of Alzheimer’s Disease |
title_full_unstemmed | Role of Natural Compounds and Target Enzymes in the Treatment of Alzheimer’s Disease |
title_short | Role of Natural Compounds and Target Enzymes in the Treatment of Alzheimer’s Disease |
title_sort | role of natural compounds and target enzymes in the treatment of alzheimer’s disease |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9268689/ https://www.ncbi.nlm.nih.gov/pubmed/35807418 http://dx.doi.org/10.3390/molecules27134175 |
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