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Role of Natural Compounds and Target Enzymes in the Treatment of Alzheimer’s Disease

Alzheimer’s disease (AD) is a progressive neurological condition. The rising prevalence of AD necessitates the rapid development of efficient therapy options. Despite substantial study, only a few medications are capable of delaying the disease. Several substances with pharmacological activity, deri...

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Autores principales: Wang, Shanshan, Kong, Xianbo, Chen, Zhangjing, Wang, Guopin, Zhang, Juan, Wang, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9268689/
https://www.ncbi.nlm.nih.gov/pubmed/35807418
http://dx.doi.org/10.3390/molecules27134175
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author Wang, Shanshan
Kong, Xianbo
Chen, Zhangjing
Wang, Guopin
Zhang, Juan
Wang, Jing
author_facet Wang, Shanshan
Kong, Xianbo
Chen, Zhangjing
Wang, Guopin
Zhang, Juan
Wang, Jing
author_sort Wang, Shanshan
collection PubMed
description Alzheimer’s disease (AD) is a progressive neurological condition. The rising prevalence of AD necessitates the rapid development of efficient therapy options. Despite substantial study, only a few medications are capable of delaying the disease. Several substances with pharmacological activity, derived from plants, have been shown to have positive benefits for the treatment of AD by targeting various enzymes, such as acetylcholinesterase (AChE), butyrylcholinesterase (BuChE), β-secretase, γ-secretase, and monoamine oxidases (MAOs), which are discussed as potential targets. Medicinal plants have already contributed a number of lead molecules to medicine development, with many of them currently undergoing clinical trials. A variety of medicinal plants have been shown to diminish the degenerative symptoms associated with AD, either in their raw form or as isolated compounds. The aim of this review was to provide a brief summary of AD and its current therapies, followed by a discussion of the natural compounds examined as therapeutic agents and the processes underlying the positive effects, particularly the management of AD.
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spelling pubmed-92686892022-07-09 Role of Natural Compounds and Target Enzymes in the Treatment of Alzheimer’s Disease Wang, Shanshan Kong, Xianbo Chen, Zhangjing Wang, Guopin Zhang, Juan Wang, Jing Molecules Review Alzheimer’s disease (AD) is a progressive neurological condition. The rising prevalence of AD necessitates the rapid development of efficient therapy options. Despite substantial study, only a few medications are capable of delaying the disease. Several substances with pharmacological activity, derived from plants, have been shown to have positive benefits for the treatment of AD by targeting various enzymes, such as acetylcholinesterase (AChE), butyrylcholinesterase (BuChE), β-secretase, γ-secretase, and monoamine oxidases (MAOs), which are discussed as potential targets. Medicinal plants have already contributed a number of lead molecules to medicine development, with many of them currently undergoing clinical trials. A variety of medicinal plants have been shown to diminish the degenerative symptoms associated with AD, either in their raw form or as isolated compounds. The aim of this review was to provide a brief summary of AD and its current therapies, followed by a discussion of the natural compounds examined as therapeutic agents and the processes underlying the positive effects, particularly the management of AD. MDPI 2022-06-29 /pmc/articles/PMC9268689/ /pubmed/35807418 http://dx.doi.org/10.3390/molecules27134175 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Wang, Shanshan
Kong, Xianbo
Chen, Zhangjing
Wang, Guopin
Zhang, Juan
Wang, Jing
Role of Natural Compounds and Target Enzymes in the Treatment of Alzheimer’s Disease
title Role of Natural Compounds and Target Enzymes in the Treatment of Alzheimer’s Disease
title_full Role of Natural Compounds and Target Enzymes in the Treatment of Alzheimer’s Disease
title_fullStr Role of Natural Compounds and Target Enzymes in the Treatment of Alzheimer’s Disease
title_full_unstemmed Role of Natural Compounds and Target Enzymes in the Treatment of Alzheimer’s Disease
title_short Role of Natural Compounds and Target Enzymes in the Treatment of Alzheimer’s Disease
title_sort role of natural compounds and target enzymes in the treatment of alzheimer’s disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9268689/
https://www.ncbi.nlm.nih.gov/pubmed/35807418
http://dx.doi.org/10.3390/molecules27134175
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