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Vitamin D and Bone Health of Older Adults within Care Homes: An Observational Study

Limited studies have reported vitamin D status and health outcomes in care home residents, a group at risk of vitamin D deficiency. This study investigated serum 25-hydroxyvitamin D (25-OHD) concentrations in older adults within care homes in Northern Ireland (NI) and its association with musculoske...

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Autores principales: Feehan, Orlagh, Armstrong, David J., Magee, Pamela J., Pourshahidi, Kirsty L., Strain, J. J., Beggan, Laura, Cobice, Diego F., McSorley, Emeir M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9268702/
https://www.ncbi.nlm.nih.gov/pubmed/35807859
http://dx.doi.org/10.3390/nu14132680
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author Feehan, Orlagh
Armstrong, David J.
Magee, Pamela J.
Pourshahidi, Kirsty L.
Strain, J. J.
Beggan, Laura
Cobice, Diego F.
McSorley, Emeir M.
author_facet Feehan, Orlagh
Armstrong, David J.
Magee, Pamela J.
Pourshahidi, Kirsty L.
Strain, J. J.
Beggan, Laura
Cobice, Diego F.
McSorley, Emeir M.
author_sort Feehan, Orlagh
collection PubMed
description Limited studies have reported vitamin D status and health outcomes in care home residents, a group at risk of vitamin D deficiency. This study investigated serum 25-hydroxyvitamin D (25-OHD) concentrations in older adults within care homes in Northern Ireland (NI) and its association with musculoskeletal health (ultrasound T-score, muscle strength, Timed Up & Go test (TUG)), bone turnover markers (BTMs), and immune function markers. A total of 87 participants were recruited with mean ± SD age 83.2 ± 7.9 years. Mean ± SD serum 25-OHD concentration (n 69) was 49.52 ± 35.58 nmol/L. Vitamin D deficiency (25-OHD <25 nmol/L) was observed in 34.8% (n 24) of participants with 17.4% (n 12) classified as insufficient (25-OHD 25–50 nmol/L) and 47.8% (n 33) as sufficient (25-OHD >50 nmol/L). 25-OHD concentration was not an independent predictor of T-score, muscle strength, TUG, or inflammatory cytokines. After adjusting for covariates, a significant negative association was observed between 25-OHD concentration and the BTMs; osteocalcin (β = −0.395; p = 0.001), procollagen type 1 N propeptide (P1NP) (β = −0.320; p = 0.012), and C-terminal telopeptide of type 1 collagen (CTX) (β = −0.377; p = 0.003). Higher 25-OHD concentration was positively associated with use of vitamin D ± calcium supplementation (β = 0.610; p < 0.001). Vitamin D deficiency and insufficiency were highly prevalent in this sample of care home residents in NI. Higher 25-OHD concentration was associated with greater supplement use and with reduced bone turnover, which in this population is linked with reduced bone loss. These findings emphasize the need for a mandatory vitamin D ± calcium supplementation policy specific for care home residents.
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spelling pubmed-92687022022-07-09 Vitamin D and Bone Health of Older Adults within Care Homes: An Observational Study Feehan, Orlagh Armstrong, David J. Magee, Pamela J. Pourshahidi, Kirsty L. Strain, J. J. Beggan, Laura Cobice, Diego F. McSorley, Emeir M. Nutrients Article Limited studies have reported vitamin D status and health outcomes in care home residents, a group at risk of vitamin D deficiency. This study investigated serum 25-hydroxyvitamin D (25-OHD) concentrations in older adults within care homes in Northern Ireland (NI) and its association with musculoskeletal health (ultrasound T-score, muscle strength, Timed Up & Go test (TUG)), bone turnover markers (BTMs), and immune function markers. A total of 87 participants were recruited with mean ± SD age 83.2 ± 7.9 years. Mean ± SD serum 25-OHD concentration (n 69) was 49.52 ± 35.58 nmol/L. Vitamin D deficiency (25-OHD <25 nmol/L) was observed in 34.8% (n 24) of participants with 17.4% (n 12) classified as insufficient (25-OHD 25–50 nmol/L) and 47.8% (n 33) as sufficient (25-OHD >50 nmol/L). 25-OHD concentration was not an independent predictor of T-score, muscle strength, TUG, or inflammatory cytokines. After adjusting for covariates, a significant negative association was observed between 25-OHD concentration and the BTMs; osteocalcin (β = −0.395; p = 0.001), procollagen type 1 N propeptide (P1NP) (β = −0.320; p = 0.012), and C-terminal telopeptide of type 1 collagen (CTX) (β = −0.377; p = 0.003). Higher 25-OHD concentration was positively associated with use of vitamin D ± calcium supplementation (β = 0.610; p < 0.001). Vitamin D deficiency and insufficiency were highly prevalent in this sample of care home residents in NI. Higher 25-OHD concentration was associated with greater supplement use and with reduced bone turnover, which in this population is linked with reduced bone loss. These findings emphasize the need for a mandatory vitamin D ± calcium supplementation policy specific for care home residents. MDPI 2022-06-28 /pmc/articles/PMC9268702/ /pubmed/35807859 http://dx.doi.org/10.3390/nu14132680 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Feehan, Orlagh
Armstrong, David J.
Magee, Pamela J.
Pourshahidi, Kirsty L.
Strain, J. J.
Beggan, Laura
Cobice, Diego F.
McSorley, Emeir M.
Vitamin D and Bone Health of Older Adults within Care Homes: An Observational Study
title Vitamin D and Bone Health of Older Adults within Care Homes: An Observational Study
title_full Vitamin D and Bone Health of Older Adults within Care Homes: An Observational Study
title_fullStr Vitamin D and Bone Health of Older Adults within Care Homes: An Observational Study
title_full_unstemmed Vitamin D and Bone Health of Older Adults within Care Homes: An Observational Study
title_short Vitamin D and Bone Health of Older Adults within Care Homes: An Observational Study
title_sort vitamin d and bone health of older adults within care homes: an observational study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9268702/
https://www.ncbi.nlm.nih.gov/pubmed/35807859
http://dx.doi.org/10.3390/nu14132680
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