Cebranopadol as a Novel Promising Agent for the Treatment of Pain

Opioids are used to treat pain, but despite their effectiveness, they possess several side effects such as respiratory depression, tolerance and physical dependence. Cebranopadol has been evaluated as a solution to this problem. The compound acts on the mu opioid receptor and the nociceptin/orphanin...

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Autores principales: Ziemichod, Wojciech, Kotlinska, Jolanta, Gibula-Tarlowska, Ewa, Karkoszka, Natalia, Kedzierska, Ewa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9268744/
https://www.ncbi.nlm.nih.gov/pubmed/35807228
http://dx.doi.org/10.3390/molecules27133987
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author Ziemichod, Wojciech
Kotlinska, Jolanta
Gibula-Tarlowska, Ewa
Karkoszka, Natalia
Kedzierska, Ewa
author_facet Ziemichod, Wojciech
Kotlinska, Jolanta
Gibula-Tarlowska, Ewa
Karkoszka, Natalia
Kedzierska, Ewa
author_sort Ziemichod, Wojciech
collection PubMed
description Opioids are used to treat pain, but despite their effectiveness, they possess several side effects such as respiratory depression, tolerance and physical dependence. Cebranopadol has been evaluated as a solution to this problem. The compound acts on the mu opioid receptor and the nociceptin/orphanin receptor and these receptors co-activation can reduce opioid side-effects without compromising analgesia. In the present review, we have compiled information on the effects of cebranopadol, its pharmacokinetics, and clinical trials involving cebranopadol, to further explore its promise in pain management.
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spelling pubmed-92687442022-07-09 Cebranopadol as a Novel Promising Agent for the Treatment of Pain Ziemichod, Wojciech Kotlinska, Jolanta Gibula-Tarlowska, Ewa Karkoszka, Natalia Kedzierska, Ewa Molecules Review Opioids are used to treat pain, but despite their effectiveness, they possess several side effects such as respiratory depression, tolerance and physical dependence. Cebranopadol has been evaluated as a solution to this problem. The compound acts on the mu opioid receptor and the nociceptin/orphanin receptor and these receptors co-activation can reduce opioid side-effects without compromising analgesia. In the present review, we have compiled information on the effects of cebranopadol, its pharmacokinetics, and clinical trials involving cebranopadol, to further explore its promise in pain management. MDPI 2022-06-21 /pmc/articles/PMC9268744/ /pubmed/35807228 http://dx.doi.org/10.3390/molecules27133987 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ziemichod, Wojciech
Kotlinska, Jolanta
Gibula-Tarlowska, Ewa
Karkoszka, Natalia
Kedzierska, Ewa
Cebranopadol as a Novel Promising Agent for the Treatment of Pain
title Cebranopadol as a Novel Promising Agent for the Treatment of Pain
title_full Cebranopadol as a Novel Promising Agent for the Treatment of Pain
title_fullStr Cebranopadol as a Novel Promising Agent for the Treatment of Pain
title_full_unstemmed Cebranopadol as a Novel Promising Agent for the Treatment of Pain
title_short Cebranopadol as a Novel Promising Agent for the Treatment of Pain
title_sort cebranopadol as a novel promising agent for the treatment of pain
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9268744/
https://www.ncbi.nlm.nih.gov/pubmed/35807228
http://dx.doi.org/10.3390/molecules27133987
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