Cargando…

GOS Ameliorates Nonalcoholic Fatty Liver Disease Induced by High Fat and High Sugar Diet through Lipid Metabolism and Intestinal Microbes

The treatment of nonalcoholic fatty liver disease (NAFLD) remains very challenging. This study investigated the therapeutic effect of galactose oligosaccharide (GOS), an important prebiotic, on NAFLD through in vivo and in vitro experiments and preliminarily explored the mechanism by which GOS impro...

Descripción completa

Detalles Bibliográficos
Autores principales: Qiu, Shuting, Chen, Jiajia, Bai, Yan, He, Jincan, Cao, Hua, Che, Qishi, Guo, Jiao, Su, Zhengquan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9268751/
https://www.ncbi.nlm.nih.gov/pubmed/35807929
http://dx.doi.org/10.3390/nu14132749
_version_ 1784744062175150080
author Qiu, Shuting
Chen, Jiajia
Bai, Yan
He, Jincan
Cao, Hua
Che, Qishi
Guo, Jiao
Su, Zhengquan
author_facet Qiu, Shuting
Chen, Jiajia
Bai, Yan
He, Jincan
Cao, Hua
Che, Qishi
Guo, Jiao
Su, Zhengquan
author_sort Qiu, Shuting
collection PubMed
description The treatment of nonalcoholic fatty liver disease (NAFLD) remains very challenging. This study investigated the therapeutic effect of galactose oligosaccharide (GOS), an important prebiotic, on NAFLD through in vivo and in vitro experiments and preliminarily explored the mechanism by which GOS improves liver lipid metabolism and inflammation through liver and intestinal microbiological analysis. The results of mouse liver lipidomics showed that GOS could promote body thermogenesis in mice with high-fat and high-sugar diet (HFHSD)-induced NAFLD, regulate lipolysis in liver fat cells, and accelerate glycine and cholesterol metabolism. GOS dose-dependently reduced the contents of total cholesterol (TC) and triglyceride (TG) in cells and reduced the accumulation of lipid droplets in cells. GOS also reduced the Firmicutes/Bacteroidetes ratio and altered the composition of the intestinal microbiota in mice fed a HFHSD. GOS can improve liver lipid metabolism and intestinal structure of NAFLD. These results provide a theoretical and experimental basis supporting the use of GOS as a health food with anti-NAFLD functions.
format Online
Article
Text
id pubmed-9268751
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-92687512022-07-09 GOS Ameliorates Nonalcoholic Fatty Liver Disease Induced by High Fat and High Sugar Diet through Lipid Metabolism and Intestinal Microbes Qiu, Shuting Chen, Jiajia Bai, Yan He, Jincan Cao, Hua Che, Qishi Guo, Jiao Su, Zhengquan Nutrients Article The treatment of nonalcoholic fatty liver disease (NAFLD) remains very challenging. This study investigated the therapeutic effect of galactose oligosaccharide (GOS), an important prebiotic, on NAFLD through in vivo and in vitro experiments and preliminarily explored the mechanism by which GOS improves liver lipid metabolism and inflammation through liver and intestinal microbiological analysis. The results of mouse liver lipidomics showed that GOS could promote body thermogenesis in mice with high-fat and high-sugar diet (HFHSD)-induced NAFLD, regulate lipolysis in liver fat cells, and accelerate glycine and cholesterol metabolism. GOS dose-dependently reduced the contents of total cholesterol (TC) and triglyceride (TG) in cells and reduced the accumulation of lipid droplets in cells. GOS also reduced the Firmicutes/Bacteroidetes ratio and altered the composition of the intestinal microbiota in mice fed a HFHSD. GOS can improve liver lipid metabolism and intestinal structure of NAFLD. These results provide a theoretical and experimental basis supporting the use of GOS as a health food with anti-NAFLD functions. MDPI 2022-07-01 /pmc/articles/PMC9268751/ /pubmed/35807929 http://dx.doi.org/10.3390/nu14132749 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Qiu, Shuting
Chen, Jiajia
Bai, Yan
He, Jincan
Cao, Hua
Che, Qishi
Guo, Jiao
Su, Zhengquan
GOS Ameliorates Nonalcoholic Fatty Liver Disease Induced by High Fat and High Sugar Diet through Lipid Metabolism and Intestinal Microbes
title GOS Ameliorates Nonalcoholic Fatty Liver Disease Induced by High Fat and High Sugar Diet through Lipid Metabolism and Intestinal Microbes
title_full GOS Ameliorates Nonalcoholic Fatty Liver Disease Induced by High Fat and High Sugar Diet through Lipid Metabolism and Intestinal Microbes
title_fullStr GOS Ameliorates Nonalcoholic Fatty Liver Disease Induced by High Fat and High Sugar Diet through Lipid Metabolism and Intestinal Microbes
title_full_unstemmed GOS Ameliorates Nonalcoholic Fatty Liver Disease Induced by High Fat and High Sugar Diet through Lipid Metabolism and Intestinal Microbes
title_short GOS Ameliorates Nonalcoholic Fatty Liver Disease Induced by High Fat and High Sugar Diet through Lipid Metabolism and Intestinal Microbes
title_sort gos ameliorates nonalcoholic fatty liver disease induced by high fat and high sugar diet through lipid metabolism and intestinal microbes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9268751/
https://www.ncbi.nlm.nih.gov/pubmed/35807929
http://dx.doi.org/10.3390/nu14132749
work_keys_str_mv AT qiushuting gosamelioratesnonalcoholicfattyliverdiseaseinducedbyhighfatandhighsugardietthroughlipidmetabolismandintestinalmicrobes
AT chenjiajia gosamelioratesnonalcoholicfattyliverdiseaseinducedbyhighfatandhighsugardietthroughlipidmetabolismandintestinalmicrobes
AT baiyan gosamelioratesnonalcoholicfattyliverdiseaseinducedbyhighfatandhighsugardietthroughlipidmetabolismandintestinalmicrobes
AT hejincan gosamelioratesnonalcoholicfattyliverdiseaseinducedbyhighfatandhighsugardietthroughlipidmetabolismandintestinalmicrobes
AT caohua gosamelioratesnonalcoholicfattyliverdiseaseinducedbyhighfatandhighsugardietthroughlipidmetabolismandintestinalmicrobes
AT cheqishi gosamelioratesnonalcoholicfattyliverdiseaseinducedbyhighfatandhighsugardietthroughlipidmetabolismandintestinalmicrobes
AT guojiao gosamelioratesnonalcoholicfattyliverdiseaseinducedbyhighfatandhighsugardietthroughlipidmetabolismandintestinalmicrobes
AT suzhengquan gosamelioratesnonalcoholicfattyliverdiseaseinducedbyhighfatandhighsugardietthroughlipidmetabolismandintestinalmicrobes