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Natural Biopolymers as Additional Tools for Cell Microencapsulation Applied to Cellular Therapy

One of the limitations in organ, tissue or cellular transplantations is graft rejection. To minimize or prevent this, recipients must make use of immunosuppressive drugs (IS) throughout their entire lives. However, its continuous use generally causes several side effects. Although some IS dose reduc...

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Autores principales: Cardoso, Liana Monteiro da Fonseca, Barreto, Tatiane, Gama, Jaciara Fernanda Gomes, Alves, Luiz Anastacio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9268758/
https://www.ncbi.nlm.nih.gov/pubmed/35808686
http://dx.doi.org/10.3390/polym14132641
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author Cardoso, Liana Monteiro da Fonseca
Barreto, Tatiane
Gama, Jaciara Fernanda Gomes
Alves, Luiz Anastacio
author_facet Cardoso, Liana Monteiro da Fonseca
Barreto, Tatiane
Gama, Jaciara Fernanda Gomes
Alves, Luiz Anastacio
author_sort Cardoso, Liana Monteiro da Fonseca
collection PubMed
description One of the limitations in organ, tissue or cellular transplantations is graft rejection. To minimize or prevent this, recipients must make use of immunosuppressive drugs (IS) throughout their entire lives. However, its continuous use generally causes several side effects. Although some IS dose reductions and withdrawal strategies have been employed, many patients do not adapt to these protocols and must return to conventional IS use. Therefore, many studies have been carried out to offer treatments that may avoid IS administration in the long term. A promising strategy is cellular microencapsulation. The possibility of microencapsulating cells originates from the opportunity to use biomaterials that mimic the extracellular matrix. This matrix acts as a support for cell adhesion and the syntheses of new extracellular matrix self-components followed by cell growth and survival. Furthermore, by involving the cells in a polymeric matrix, the matrix acts as an immunoprotective barrier, protecting cells against the recipient’s immune system while still allowing essential cell survival molecules to diffuse bilaterally through the polymer matrix pores. In addition, this matrix can be associated with IS, thus diminishing systemic side effects. In this context, this review will address the natural biomaterials currently in use and their importance in cell therapy.
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spelling pubmed-92687582022-07-09 Natural Biopolymers as Additional Tools for Cell Microencapsulation Applied to Cellular Therapy Cardoso, Liana Monteiro da Fonseca Barreto, Tatiane Gama, Jaciara Fernanda Gomes Alves, Luiz Anastacio Polymers (Basel) Review One of the limitations in organ, tissue or cellular transplantations is graft rejection. To minimize or prevent this, recipients must make use of immunosuppressive drugs (IS) throughout their entire lives. However, its continuous use generally causes several side effects. Although some IS dose reductions and withdrawal strategies have been employed, many patients do not adapt to these protocols and must return to conventional IS use. Therefore, many studies have been carried out to offer treatments that may avoid IS administration in the long term. A promising strategy is cellular microencapsulation. The possibility of microencapsulating cells originates from the opportunity to use biomaterials that mimic the extracellular matrix. This matrix acts as a support for cell adhesion and the syntheses of new extracellular matrix self-components followed by cell growth and survival. Furthermore, by involving the cells in a polymeric matrix, the matrix acts as an immunoprotective barrier, protecting cells against the recipient’s immune system while still allowing essential cell survival molecules to diffuse bilaterally through the polymer matrix pores. In addition, this matrix can be associated with IS, thus diminishing systemic side effects. In this context, this review will address the natural biomaterials currently in use and their importance in cell therapy. MDPI 2022-06-29 /pmc/articles/PMC9268758/ /pubmed/35808686 http://dx.doi.org/10.3390/polym14132641 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Cardoso, Liana Monteiro da Fonseca
Barreto, Tatiane
Gama, Jaciara Fernanda Gomes
Alves, Luiz Anastacio
Natural Biopolymers as Additional Tools for Cell Microencapsulation Applied to Cellular Therapy
title Natural Biopolymers as Additional Tools for Cell Microencapsulation Applied to Cellular Therapy
title_full Natural Biopolymers as Additional Tools for Cell Microencapsulation Applied to Cellular Therapy
title_fullStr Natural Biopolymers as Additional Tools for Cell Microencapsulation Applied to Cellular Therapy
title_full_unstemmed Natural Biopolymers as Additional Tools for Cell Microencapsulation Applied to Cellular Therapy
title_short Natural Biopolymers as Additional Tools for Cell Microencapsulation Applied to Cellular Therapy
title_sort natural biopolymers as additional tools for cell microencapsulation applied to cellular therapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9268758/
https://www.ncbi.nlm.nih.gov/pubmed/35808686
http://dx.doi.org/10.3390/polym14132641
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