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Self-Healing Chitosan Hydrogels: Preparation and Rheological Characterization

The paper aims at the preparation of chitosan self-healing hydrogels, designed as carriers for local drug delivery by parenteral administration. To this aim, 30 hydrogels were prepared using chitosan and pyridoxal 5-phosphate (P5P), the active form of vitamin B6 as precursors, by varying the ratio o...

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Autores principales: Craciun, Anda Mihaela, Morariu, Simona, Marin, Luminita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9268889/
https://www.ncbi.nlm.nih.gov/pubmed/35808616
http://dx.doi.org/10.3390/polym14132570
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author Craciun, Anda Mihaela
Morariu, Simona
Marin, Luminita
author_facet Craciun, Anda Mihaela
Morariu, Simona
Marin, Luminita
author_sort Craciun, Anda Mihaela
collection PubMed
description The paper aims at the preparation of chitosan self-healing hydrogels, designed as carriers for local drug delivery by parenteral administration. To this aim, 30 hydrogels were prepared using chitosan and pyridoxal 5-phosphate (P5P), the active form of vitamin B6 as precursors, by varying the ratio of glucosamine units and aldehyde on the one hand and the water content on the other hand. The driving forces of hydrogelation were investigated by nuclear magnetic resonance (NMR), Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction, and polarized light microscopy (POM) measurements. NMR technique was also used to investigate the stability of hydrogels over time, and their morphological particularities were assessed by scanning electron microscopy (SEM). Degradability of the hydrogels was studied in media of four different pH, and preliminary self-healing ability was visually established by injection through a syringe needle. In-depth rheological investigation was conducted in order to monitor the storage and loss moduli, linear viscoelastic regime, and structural recovery capacity. It was concluded that chitosan crosslinking with pyridoxal 5-phosphate is a suitable route to reach self-healing hydrogels with a good balance of mechanical properties/structural recovery, good stability over time, and degradability controlled by pH.
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spelling pubmed-92688892022-07-09 Self-Healing Chitosan Hydrogels: Preparation and Rheological Characterization Craciun, Anda Mihaela Morariu, Simona Marin, Luminita Polymers (Basel) Article The paper aims at the preparation of chitosan self-healing hydrogels, designed as carriers for local drug delivery by parenteral administration. To this aim, 30 hydrogels were prepared using chitosan and pyridoxal 5-phosphate (P5P), the active form of vitamin B6 as precursors, by varying the ratio of glucosamine units and aldehyde on the one hand and the water content on the other hand. The driving forces of hydrogelation were investigated by nuclear magnetic resonance (NMR), Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction, and polarized light microscopy (POM) measurements. NMR technique was also used to investigate the stability of hydrogels over time, and their morphological particularities were assessed by scanning electron microscopy (SEM). Degradability of the hydrogels was studied in media of four different pH, and preliminary self-healing ability was visually established by injection through a syringe needle. In-depth rheological investigation was conducted in order to monitor the storage and loss moduli, linear viscoelastic regime, and structural recovery capacity. It was concluded that chitosan crosslinking with pyridoxal 5-phosphate is a suitable route to reach self-healing hydrogels with a good balance of mechanical properties/structural recovery, good stability over time, and degradability controlled by pH. MDPI 2022-06-24 /pmc/articles/PMC9268889/ /pubmed/35808616 http://dx.doi.org/10.3390/polym14132570 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Craciun, Anda Mihaela
Morariu, Simona
Marin, Luminita
Self-Healing Chitosan Hydrogels: Preparation and Rheological Characterization
title Self-Healing Chitosan Hydrogels: Preparation and Rheological Characterization
title_full Self-Healing Chitosan Hydrogels: Preparation and Rheological Characterization
title_fullStr Self-Healing Chitosan Hydrogels: Preparation and Rheological Characterization
title_full_unstemmed Self-Healing Chitosan Hydrogels: Preparation and Rheological Characterization
title_short Self-Healing Chitosan Hydrogels: Preparation and Rheological Characterization
title_sort self-healing chitosan hydrogels: preparation and rheological characterization
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9268889/
https://www.ncbi.nlm.nih.gov/pubmed/35808616
http://dx.doi.org/10.3390/polym14132570
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