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Evaluation of a High-Sensitivity Organ-Targeted PET Camera
The aim of this study is to evaluate the performance of the Radialis organ-targeted positron emission tomography (PET) Camera with standardized tests and through assessment of clinical-imaging results. Sensitivity, count-rate performance, and spatial resolution were evaluated according to the Nation...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9269056/ https://www.ncbi.nlm.nih.gov/pubmed/35808181 http://dx.doi.org/10.3390/s22134678 |
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author | Stiles, Justin Baldassi, Brandon Bubon, Oleksandr Poladyan, Harutyun Freitas, Vivianne Scaranelo, Anabel Mulligan, Anna Marie Waterston, Michael Reznik, Alla |
author_facet | Stiles, Justin Baldassi, Brandon Bubon, Oleksandr Poladyan, Harutyun Freitas, Vivianne Scaranelo, Anabel Mulligan, Anna Marie Waterston, Michael Reznik, Alla |
author_sort | Stiles, Justin |
collection | PubMed |
description | The aim of this study is to evaluate the performance of the Radialis organ-targeted positron emission tomography (PET) Camera with standardized tests and through assessment of clinical-imaging results. Sensitivity, count-rate performance, and spatial resolution were evaluated according to the National Electrical Manufacturers Association (NEMA) NU-4 standards, with necessary modifications to accommodate the planar detector design. The detectability of small objects was shown with micro hotspot phantom images. The clinical performance of the camera was also demonstrated through breast cancer images acquired with varying injected doses of 2-[fluorine-18]-fluoro-2-deoxy-D-glucose ((18)F-FDG) and qualitatively compared with sample digital full-field mammography, magnetic resonance imaging (MRI), and whole-body (WB) PET images. Micro hotspot phantom sources were visualized down to 1.35 mm-diameter rods. Spatial resolution was calculated to be 2.3 ± 0.1 mm for the in-plane resolution and 6.8 ± 0.1 mm for the cross-plane resolution using maximum likelihood expectation maximization (MLEM) reconstruction. The system peak noise equivalent count rate was 17.8 kcps at a (18)F-FDG concentration of 10.5 kBq/mL. System scatter fraction was 24%. The overall efficiency at the peak noise equivalent count rate was 5400 cps/MBq. The maximum axial sensitivity achieved was 3.5%, with an average system sensitivity of 2.4%. Selected results from clinical trials demonstrate capability of imaging lesions at the chest wall and identifying false-negative X-ray findings and false-positive MRI findings, even at up to a 10-fold dose reduction in comparison with standard (18)F-FDG doses (i.e., at 37 MBq or 1 mCi). The evaluation of the organ-targeted Radialis PET Camera indicates that it is a promising technology for high-image-quality, low-dose PET imaging. High-efficiency radiotracer detection also opens an opportunity to reduce administered doses of radiopharmaceuticals and, therefore, patient exposure to radiation. |
format | Online Article Text |
id | pubmed-9269056 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-92690562022-07-09 Evaluation of a High-Sensitivity Organ-Targeted PET Camera Stiles, Justin Baldassi, Brandon Bubon, Oleksandr Poladyan, Harutyun Freitas, Vivianne Scaranelo, Anabel Mulligan, Anna Marie Waterston, Michael Reznik, Alla Sensors (Basel) Article The aim of this study is to evaluate the performance of the Radialis organ-targeted positron emission tomography (PET) Camera with standardized tests and through assessment of clinical-imaging results. Sensitivity, count-rate performance, and spatial resolution were evaluated according to the National Electrical Manufacturers Association (NEMA) NU-4 standards, with necessary modifications to accommodate the planar detector design. The detectability of small objects was shown with micro hotspot phantom images. The clinical performance of the camera was also demonstrated through breast cancer images acquired with varying injected doses of 2-[fluorine-18]-fluoro-2-deoxy-D-glucose ((18)F-FDG) and qualitatively compared with sample digital full-field mammography, magnetic resonance imaging (MRI), and whole-body (WB) PET images. Micro hotspot phantom sources were visualized down to 1.35 mm-diameter rods. Spatial resolution was calculated to be 2.3 ± 0.1 mm for the in-plane resolution and 6.8 ± 0.1 mm for the cross-plane resolution using maximum likelihood expectation maximization (MLEM) reconstruction. The system peak noise equivalent count rate was 17.8 kcps at a (18)F-FDG concentration of 10.5 kBq/mL. System scatter fraction was 24%. The overall efficiency at the peak noise equivalent count rate was 5400 cps/MBq. The maximum axial sensitivity achieved was 3.5%, with an average system sensitivity of 2.4%. Selected results from clinical trials demonstrate capability of imaging lesions at the chest wall and identifying false-negative X-ray findings and false-positive MRI findings, even at up to a 10-fold dose reduction in comparison with standard (18)F-FDG doses (i.e., at 37 MBq or 1 mCi). The evaluation of the organ-targeted Radialis PET Camera indicates that it is a promising technology for high-image-quality, low-dose PET imaging. High-efficiency radiotracer detection also opens an opportunity to reduce administered doses of radiopharmaceuticals and, therefore, patient exposure to radiation. MDPI 2022-06-21 /pmc/articles/PMC9269056/ /pubmed/35808181 http://dx.doi.org/10.3390/s22134678 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Stiles, Justin Baldassi, Brandon Bubon, Oleksandr Poladyan, Harutyun Freitas, Vivianne Scaranelo, Anabel Mulligan, Anna Marie Waterston, Michael Reznik, Alla Evaluation of a High-Sensitivity Organ-Targeted PET Camera |
title | Evaluation of a High-Sensitivity Organ-Targeted PET Camera |
title_full | Evaluation of a High-Sensitivity Organ-Targeted PET Camera |
title_fullStr | Evaluation of a High-Sensitivity Organ-Targeted PET Camera |
title_full_unstemmed | Evaluation of a High-Sensitivity Organ-Targeted PET Camera |
title_short | Evaluation of a High-Sensitivity Organ-Targeted PET Camera |
title_sort | evaluation of a high-sensitivity organ-targeted pet camera |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9269056/ https://www.ncbi.nlm.nih.gov/pubmed/35808181 http://dx.doi.org/10.3390/s22134678 |
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