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Hepatitis C-related membranoproliferative glomerulonephritis in the era of direct antiviral agents
Membranoproliferative glomerulonephritis (MPGN) is the most typical Hepatitis C virus (HCV)-associated glomerulopathy, and the available data about the utilization of direct-acting antivirals (DAA) in HCV-associated glomerulonephritis is inadequate. We evaluated the renal and viral response in two c...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Sociedade Brasileira de Nefrologia
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9269171/ https://www.ncbi.nlm.nih.gov/pubmed/33605311 http://dx.doi.org/10.1590/2175-8239-JBN-2020-0148 |
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author | Abdelhamid, Walid Ahmed Ragab Shendi, Ali Zahran, Mahmoud Elbary, Eman Abd Fadda, Sawsan |
author_facet | Abdelhamid, Walid Ahmed Ragab Shendi, Ali Zahran, Mahmoud Elbary, Eman Abd Fadda, Sawsan |
author_sort | Abdelhamid, Walid Ahmed Ragab |
collection | PubMed |
description | Membranoproliferative glomerulonephritis (MPGN) is the most typical Hepatitis C virus (HCV)-associated glomerulopathy, and the available data about the utilization of direct-acting antivirals (DAA) in HCV-associated glomerulonephritis is inadequate. We evaluated the renal and viral response in two cases of HCV-related MPGN; the first caused by cryoglobulinemia while the second was cryoglobulin-negative. Both patients received immunosuppression besides DAA in different regimens. They achieved partial remission but remained immunosuppression-dependent for more than 6 months after DAA despite sustained virological response, which enabled safer but incomplete immunosuppression withdrawal. Both patients were tested for occult HCV in peripheral blood mononuclear cells and found to be negative. Hence, the treatment of HCV-related MPGN ought to be according to the clinical condition and the effects of drug therapy. It is important to consider that renal response can lag behind the virological response. |
format | Online Article Text |
id | pubmed-9269171 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Sociedade Brasileira de Nefrologia |
record_format | MEDLINE/PubMed |
spelling | pubmed-92691712022-07-20 Hepatitis C-related membranoproliferative glomerulonephritis in the era of direct antiviral agents Abdelhamid, Walid Ahmed Ragab Shendi, Ali Zahran, Mahmoud Elbary, Eman Abd Fadda, Sawsan J Bras Nefrol Case Report Membranoproliferative glomerulonephritis (MPGN) is the most typical Hepatitis C virus (HCV)-associated glomerulopathy, and the available data about the utilization of direct-acting antivirals (DAA) in HCV-associated glomerulonephritis is inadequate. We evaluated the renal and viral response in two cases of HCV-related MPGN; the first caused by cryoglobulinemia while the second was cryoglobulin-negative. Both patients received immunosuppression besides DAA in different regimens. They achieved partial remission but remained immunosuppression-dependent for more than 6 months after DAA despite sustained virological response, which enabled safer but incomplete immunosuppression withdrawal. Both patients were tested for occult HCV in peripheral blood mononuclear cells and found to be negative. Hence, the treatment of HCV-related MPGN ought to be according to the clinical condition and the effects of drug therapy. It is important to consider that renal response can lag behind the virological response. Sociedade Brasileira de Nefrologia 2021-02-12 2022 /pmc/articles/PMC9269171/ /pubmed/33605311 http://dx.doi.org/10.1590/2175-8239-JBN-2020-0148 Text en https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Abdelhamid, Walid Ahmed Ragab Shendi, Ali Zahran, Mahmoud Elbary, Eman Abd Fadda, Sawsan Hepatitis C-related membranoproliferative glomerulonephritis in the era of direct antiviral agents |
title | Hepatitis C-related membranoproliferative glomerulonephritis in the era of direct antiviral agents |
title_full | Hepatitis C-related membranoproliferative glomerulonephritis in the era of direct antiviral agents |
title_fullStr | Hepatitis C-related membranoproliferative glomerulonephritis in the era of direct antiviral agents |
title_full_unstemmed | Hepatitis C-related membranoproliferative glomerulonephritis in the era of direct antiviral agents |
title_short | Hepatitis C-related membranoproliferative glomerulonephritis in the era of direct antiviral agents |
title_sort | hepatitis c-related membranoproliferative glomerulonephritis in the era of direct antiviral agents |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9269171/ https://www.ncbi.nlm.nih.gov/pubmed/33605311 http://dx.doi.org/10.1590/2175-8239-JBN-2020-0148 |
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