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Performance of creatinine-based equations for estimating glomerular filtration rate compared to endogenous creatinine clearance

INTRODUCTION: The guidelines recommend estimating the glomerular filtration rate using serum creatinine-based equations as a predictor of kidney disease, preferably adjusted for local population groups. METHODS: Cross-sectional study that evaluated the performance of four equations used for estimati...

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Autores principales: da Fonseca, Gisele da Silva, de Souza, Vandréa Carla, Bilibio, Sarah Assoni, Carobin, Vanessa, Facin, Lígia, Koch, Ketelly, Machado, Morgana, Dubourg, Laurence, Selistre, Luciano da Silva
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Nefrologia 2021
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9269182/
https://www.ncbi.nlm.nih.gov/pubmed/34874985
http://dx.doi.org/10.1590/2175-8239-JBN-2021-0109
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author da Fonseca, Gisele da Silva
de Souza, Vandréa Carla
Bilibio, Sarah Assoni
Carobin, Vanessa
Facin, Lígia
Koch, Ketelly
Machado, Morgana
Dubourg, Laurence
Selistre, Luciano da Silva
author_facet da Fonseca, Gisele da Silva
de Souza, Vandréa Carla
Bilibio, Sarah Assoni
Carobin, Vanessa
Facin, Lígia
Koch, Ketelly
Machado, Morgana
Dubourg, Laurence
Selistre, Luciano da Silva
author_sort da Fonseca, Gisele da Silva
collection PubMed
description INTRODUCTION: The guidelines recommend estimating the glomerular filtration rate using serum creatinine-based equations as a predictor of kidney disease, preferably adjusted for local population groups. METHODS: Cross-sectional study that evaluated the performance of four equations used for estimating GFR compared to endogenous creatinine clearance (ClCr) in 1,281 participants. Modification of Diet equations in Renal Disease Study Group (MDRD), Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI), CKD-EPI with adjustment for local population (CKD-EPI local) and Full Age Spectrum (FAS) in comparison with endogenous creatinine clearance (ClCr). We used the Quantile Regression to calculate the median bias, interquartile range (IQR), Bland-Altman agreement analysis and 30% margin of error (P(30)). RESULTS: The mean age of participants was 52.5 ± 16.5 years with 466 women (38%), median ClCr[IQR] of 92.0 [58.0; 122.0] mL/min/1.73 m(2), with 320 (25%) participants presenting ClCr < 60 mL/min/1.73 m(2). The performance of the local CKD-EPI and FAS equations were superior to MDRD and CKD-EPI in relation to variability (0.92 [0.89; 0.94]) and P(30) (90.5% [88.7; 92, 0]). In the group with ClCr < 60 mL/min/1.73 m(2), the local CKD-EPI and FAS equations showed less variability than the CKD-EPI and MDRD (0.90 [0.86; 0.98] and 1.05 [0.97; 1.09] vs. 0.63 [0.61; 0.68] and 0.65 [0.62; 0.70], P < 0.01) and best P(30) (85.5) % [81.0; 90.0], 88.0% [84.0; 92.0] vs. 52.0% (46.0; 58.0) and 53.0% [47.0; 58 .5], P < 0.01). CONCLUSION: Local CKD-EPI and FAS equations performed better than CKD-EPI and MDRD when compared to ClCr.
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spelling pubmed-92691822022-07-20 Performance of creatinine-based equations for estimating glomerular filtration rate compared to endogenous creatinine clearance da Fonseca, Gisele da Silva de Souza, Vandréa Carla Bilibio, Sarah Assoni Carobin, Vanessa Facin, Lígia Koch, Ketelly Machado, Morgana Dubourg, Laurence Selistre, Luciano da Silva J Bras Nefrol Original Article INTRODUCTION: The guidelines recommend estimating the glomerular filtration rate using serum creatinine-based equations as a predictor of kidney disease, preferably adjusted for local population groups. METHODS: Cross-sectional study that evaluated the performance of four equations used for estimating GFR compared to endogenous creatinine clearance (ClCr) in 1,281 participants. Modification of Diet equations in Renal Disease Study Group (MDRD), Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI), CKD-EPI with adjustment for local population (CKD-EPI local) and Full Age Spectrum (FAS) in comparison with endogenous creatinine clearance (ClCr). We used the Quantile Regression to calculate the median bias, interquartile range (IQR), Bland-Altman agreement analysis and 30% margin of error (P(30)). RESULTS: The mean age of participants was 52.5 ± 16.5 years with 466 women (38%), median ClCr[IQR] of 92.0 [58.0; 122.0] mL/min/1.73 m(2), with 320 (25%) participants presenting ClCr < 60 mL/min/1.73 m(2). The performance of the local CKD-EPI and FAS equations were superior to MDRD and CKD-EPI in relation to variability (0.92 [0.89; 0.94]) and P(30) (90.5% [88.7; 92, 0]). In the group with ClCr < 60 mL/min/1.73 m(2), the local CKD-EPI and FAS equations showed less variability than the CKD-EPI and MDRD (0.90 [0.86; 0.98] and 1.05 [0.97; 1.09] vs. 0.63 [0.61; 0.68] and 0.65 [0.62; 0.70], P < 0.01) and best P(30) (85.5) % [81.0; 90.0], 88.0% [84.0; 92.0] vs. 52.0% (46.0; 58.0) and 53.0% [47.0; 58 .5], P < 0.01). CONCLUSION: Local CKD-EPI and FAS equations performed better than CKD-EPI and MDRD when compared to ClCr. Sociedade Brasileira de Nefrologia 2021-12-06 2022 /pmc/articles/PMC9269182/ /pubmed/34874985 http://dx.doi.org/10.1590/2175-8239-JBN-2021-0109 Text en https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
da Fonseca, Gisele da Silva
de Souza, Vandréa Carla
Bilibio, Sarah Assoni
Carobin, Vanessa
Facin, Lígia
Koch, Ketelly
Machado, Morgana
Dubourg, Laurence
Selistre, Luciano da Silva
Performance of creatinine-based equations for estimating glomerular filtration rate compared to endogenous creatinine clearance
title Performance of creatinine-based equations for estimating glomerular filtration rate compared to endogenous creatinine clearance
title_full Performance of creatinine-based equations for estimating glomerular filtration rate compared to endogenous creatinine clearance
title_fullStr Performance of creatinine-based equations for estimating glomerular filtration rate compared to endogenous creatinine clearance
title_full_unstemmed Performance of creatinine-based equations for estimating glomerular filtration rate compared to endogenous creatinine clearance
title_short Performance of creatinine-based equations for estimating glomerular filtration rate compared to endogenous creatinine clearance
title_sort performance of creatinine-based equations for estimating glomerular filtration rate compared to endogenous creatinine clearance
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9269182/
https://www.ncbi.nlm.nih.gov/pubmed/34874985
http://dx.doi.org/10.1590/2175-8239-JBN-2021-0109
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