Cargando…

Effects of a Long-Term Wearable Activity Tracker-Based Exercise Intervention on Cardiac Morphology and Function of Patients with Cystic Fibrosis

Several studies have shown that patients with cystic fibrosis (CF), even at a young age, have pulmonary and cardiac abnormalities. The main complications are cardiac right ventricular (RV) systolic and/or diastolic dysfunction and pulmonary hypertension, which affects their prognosis. Exercise train...

Descripción completa

Detalles Bibliográficos
Autores principales: Anifanti, Maria, Giannakoulakos, Stavros, Hatziagorou, Elpis, Kampouras, Asterios, Tsanakas, John, Deligiannis, Asterios, Kouidi, Evangelia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9269327/
https://www.ncbi.nlm.nih.gov/pubmed/35808375
http://dx.doi.org/10.3390/s22134884
_version_ 1784744208556359680
author Anifanti, Maria
Giannakoulakos, Stavros
Hatziagorou, Elpis
Kampouras, Asterios
Tsanakas, John
Deligiannis, Asterios
Kouidi, Evangelia
author_facet Anifanti, Maria
Giannakoulakos, Stavros
Hatziagorou, Elpis
Kampouras, Asterios
Tsanakas, John
Deligiannis, Asterios
Kouidi, Evangelia
author_sort Anifanti, Maria
collection PubMed
description Several studies have shown that patients with cystic fibrosis (CF), even at a young age, have pulmonary and cardiac abnormalities. The main complications are cardiac right ventricular (RV) systolic and/or diastolic dysfunction and pulmonary hypertension, which affects their prognosis. Exercise training (ET) is recommended in patients with CF as a therapeutic modality to improve physical fitness and health-related quality of life. However, questions remain regarding its optimal effective and safe dose and its effects on the patients’ cardiac function. The study aimed to provide a wearable activity tracker (WAT)-based ET to promote physical activity in CF patients and assess its effects on cardiac morphology and function. Forty-two stable CF individuals (aged 16.8 ± 3.6 years) were randomly assigned to either the intervention (Group A) or the control group (Group B). Group A participated in a 1-year WAT-based ET program three times per week. All patients underwent a 6-min walking test (6-MWT) and an echocardiographic assessment focused mainly on RV anatomy and function at the baseline and the end of the study. RV systolic function was evaluated by measuring the tricuspid annular plane systolic excursion (TAPSE), the systolic tricuspid annular velocity (TVS’), the RV free-wall longitudinal strain (RVFWSL), and the right ventricular four-chamber longitudinal strain (RV4CSL). RV diastolic function was assessed using early (TVE) and late (TVA) diastolic transtricuspid flow velocity and their ratio TVE/A. Pulmonary artery systolic pressure (PASP) was also estimated. In Group A after ET, the 6MWT distance improved by 20.6% (p < 0.05), TVA decreased by 17% (p < 0.05), and TVE/A increased by 13.2% (p < 0.05). Moreover, TAPSE, TVS’, RVFWSL, and RV4CSL increased by 8.3% (p < 0.05), 9.0% (p < 0.05), 13.7% (p < 0.05), and 26.7% (p < 0.05), respectively, while PASP decreased by 7.6% (p < 0.05). At the end of the study, there was a significant linear correlation between the number of steps and the PASP (r = −0.727, p < 0.01) as well as the indices of RV systolic function in Group A. In conclusion, WAT is a valuable tool for implementing an effective ET program in CF. Furthermore, ET has a positive effect on RV systolic and diastolic function.
format Online
Article
Text
id pubmed-9269327
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-92693272022-07-09 Effects of a Long-Term Wearable Activity Tracker-Based Exercise Intervention on Cardiac Morphology and Function of Patients with Cystic Fibrosis Anifanti, Maria Giannakoulakos, Stavros Hatziagorou, Elpis Kampouras, Asterios Tsanakas, John Deligiannis, Asterios Kouidi, Evangelia Sensors (Basel) Article Several studies have shown that patients with cystic fibrosis (CF), even at a young age, have pulmonary and cardiac abnormalities. The main complications are cardiac right ventricular (RV) systolic and/or diastolic dysfunction and pulmonary hypertension, which affects their prognosis. Exercise training (ET) is recommended in patients with CF as a therapeutic modality to improve physical fitness and health-related quality of life. However, questions remain regarding its optimal effective and safe dose and its effects on the patients’ cardiac function. The study aimed to provide a wearable activity tracker (WAT)-based ET to promote physical activity in CF patients and assess its effects on cardiac morphology and function. Forty-two stable CF individuals (aged 16.8 ± 3.6 years) were randomly assigned to either the intervention (Group A) or the control group (Group B). Group A participated in a 1-year WAT-based ET program three times per week. All patients underwent a 6-min walking test (6-MWT) and an echocardiographic assessment focused mainly on RV anatomy and function at the baseline and the end of the study. RV systolic function was evaluated by measuring the tricuspid annular plane systolic excursion (TAPSE), the systolic tricuspid annular velocity (TVS’), the RV free-wall longitudinal strain (RVFWSL), and the right ventricular four-chamber longitudinal strain (RV4CSL). RV diastolic function was assessed using early (TVE) and late (TVA) diastolic transtricuspid flow velocity and their ratio TVE/A. Pulmonary artery systolic pressure (PASP) was also estimated. In Group A after ET, the 6MWT distance improved by 20.6% (p < 0.05), TVA decreased by 17% (p < 0.05), and TVE/A increased by 13.2% (p < 0.05). Moreover, TAPSE, TVS’, RVFWSL, and RV4CSL increased by 8.3% (p < 0.05), 9.0% (p < 0.05), 13.7% (p < 0.05), and 26.7% (p < 0.05), respectively, while PASP decreased by 7.6% (p < 0.05). At the end of the study, there was a significant linear correlation between the number of steps and the PASP (r = −0.727, p < 0.01) as well as the indices of RV systolic function in Group A. In conclusion, WAT is a valuable tool for implementing an effective ET program in CF. Furthermore, ET has a positive effect on RV systolic and diastolic function. MDPI 2022-06-28 /pmc/articles/PMC9269327/ /pubmed/35808375 http://dx.doi.org/10.3390/s22134884 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Anifanti, Maria
Giannakoulakos, Stavros
Hatziagorou, Elpis
Kampouras, Asterios
Tsanakas, John
Deligiannis, Asterios
Kouidi, Evangelia
Effects of a Long-Term Wearable Activity Tracker-Based Exercise Intervention on Cardiac Morphology and Function of Patients with Cystic Fibrosis
title Effects of a Long-Term Wearable Activity Tracker-Based Exercise Intervention on Cardiac Morphology and Function of Patients with Cystic Fibrosis
title_full Effects of a Long-Term Wearable Activity Tracker-Based Exercise Intervention on Cardiac Morphology and Function of Patients with Cystic Fibrosis
title_fullStr Effects of a Long-Term Wearable Activity Tracker-Based Exercise Intervention on Cardiac Morphology and Function of Patients with Cystic Fibrosis
title_full_unstemmed Effects of a Long-Term Wearable Activity Tracker-Based Exercise Intervention on Cardiac Morphology and Function of Patients with Cystic Fibrosis
title_short Effects of a Long-Term Wearable Activity Tracker-Based Exercise Intervention on Cardiac Morphology and Function of Patients with Cystic Fibrosis
title_sort effects of a long-term wearable activity tracker-based exercise intervention on cardiac morphology and function of patients with cystic fibrosis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9269327/
https://www.ncbi.nlm.nih.gov/pubmed/35808375
http://dx.doi.org/10.3390/s22134884
work_keys_str_mv AT anifantimaria effectsofalongtermwearableactivitytrackerbasedexerciseinterventiononcardiacmorphologyandfunctionofpatientswithcysticfibrosis
AT giannakoulakosstavros effectsofalongtermwearableactivitytrackerbasedexerciseinterventiononcardiacmorphologyandfunctionofpatientswithcysticfibrosis
AT hatziagorouelpis effectsofalongtermwearableactivitytrackerbasedexerciseinterventiononcardiacmorphologyandfunctionofpatientswithcysticfibrosis
AT kampourasasterios effectsofalongtermwearableactivitytrackerbasedexerciseinterventiononcardiacmorphologyandfunctionofpatientswithcysticfibrosis
AT tsanakasjohn effectsofalongtermwearableactivitytrackerbasedexerciseinterventiononcardiacmorphologyandfunctionofpatientswithcysticfibrosis
AT deligiannisasterios effectsofalongtermwearableactivitytrackerbasedexerciseinterventiononcardiacmorphologyandfunctionofpatientswithcysticfibrosis
AT kouidievangelia effectsofalongtermwearableactivitytrackerbasedexerciseinterventiononcardiacmorphologyandfunctionofpatientswithcysticfibrosis