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Accuracy and consistency of intensity-based deformable image registration in 4DCT for tumor motion estimation in liver radiotherapy planning

We investigate the accuracy of intensity-based deformable image registration (DIR) for tumor localization in liver stereotactic body radiotherapy (SBRT). We included 4DCT scans to capture the breathing motion of eight patients receiving SBRT for liver metastases within a retrospective clinical study...

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Autores principales: Tascón-Vidarte, José D., Stick, Line Bjerregaard, Josipovic, Mirjana, Risum, Signe, Jomier, Julien, Erleben, Kenny, Vogelius, Ivan Richter, Darkner, Sune
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9269460/
https://www.ncbi.nlm.nih.gov/pubmed/35802593
http://dx.doi.org/10.1371/journal.pone.0271064
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author Tascón-Vidarte, José D.
Stick, Line Bjerregaard
Josipovic, Mirjana
Risum, Signe
Jomier, Julien
Erleben, Kenny
Vogelius, Ivan Richter
Darkner, Sune
author_facet Tascón-Vidarte, José D.
Stick, Line Bjerregaard
Josipovic, Mirjana
Risum, Signe
Jomier, Julien
Erleben, Kenny
Vogelius, Ivan Richter
Darkner, Sune
author_sort Tascón-Vidarte, José D.
collection PubMed
description We investigate the accuracy of intensity-based deformable image registration (DIR) for tumor localization in liver stereotactic body radiotherapy (SBRT). We included 4DCT scans to capture the breathing motion of eight patients receiving SBRT for liver metastases within a retrospective clinical study. Each patient had three fiducial markers implanted. The liver and the tumor were delineated in the mid-ventilation phase, and their positions in the other phases were estimated with deformable image registration. We tested referenced and sequential registrations strategies. The fiducial markers were the gold standard to evaluate registration accuracy. The registration errors related to measured versus estimated fiducial markers showed a mean value less than 1.6mm. The positions of some fiducial markers appeared not stable on the 4DCT throughout the respiratory phases. Markers’ center of mass tends to be a more reliable measurement. Distance errors of tumor location based on registration versus markers center of mass were less than 2mm. There were no statistically significant differences between the reference and the sequential registration, i.e., consistency and errors were comparable to resolution errors. We demonstrated that intensity-based DIR is accurate up to resolution level for locating the tumor in the liver during breathing motion.
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spelling pubmed-92694602022-07-09 Accuracy and consistency of intensity-based deformable image registration in 4DCT for tumor motion estimation in liver radiotherapy planning Tascón-Vidarte, José D. Stick, Line Bjerregaard Josipovic, Mirjana Risum, Signe Jomier, Julien Erleben, Kenny Vogelius, Ivan Richter Darkner, Sune PLoS One Research Article We investigate the accuracy of intensity-based deformable image registration (DIR) for tumor localization in liver stereotactic body radiotherapy (SBRT). We included 4DCT scans to capture the breathing motion of eight patients receiving SBRT for liver metastases within a retrospective clinical study. Each patient had three fiducial markers implanted. The liver and the tumor were delineated in the mid-ventilation phase, and their positions in the other phases were estimated with deformable image registration. We tested referenced and sequential registrations strategies. The fiducial markers were the gold standard to evaluate registration accuracy. The registration errors related to measured versus estimated fiducial markers showed a mean value less than 1.6mm. The positions of some fiducial markers appeared not stable on the 4DCT throughout the respiratory phases. Markers’ center of mass tends to be a more reliable measurement. Distance errors of tumor location based on registration versus markers center of mass were less than 2mm. There were no statistically significant differences between the reference and the sequential registration, i.e., consistency and errors were comparable to resolution errors. We demonstrated that intensity-based DIR is accurate up to resolution level for locating the tumor in the liver during breathing motion. Public Library of Science 2022-07-08 /pmc/articles/PMC9269460/ /pubmed/35802593 http://dx.doi.org/10.1371/journal.pone.0271064 Text en © 2022 Tascón-Vidarte et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Tascón-Vidarte, José D.
Stick, Line Bjerregaard
Josipovic, Mirjana
Risum, Signe
Jomier, Julien
Erleben, Kenny
Vogelius, Ivan Richter
Darkner, Sune
Accuracy and consistency of intensity-based deformable image registration in 4DCT for tumor motion estimation in liver radiotherapy planning
title Accuracy and consistency of intensity-based deformable image registration in 4DCT for tumor motion estimation in liver radiotherapy planning
title_full Accuracy and consistency of intensity-based deformable image registration in 4DCT for tumor motion estimation in liver radiotherapy planning
title_fullStr Accuracy and consistency of intensity-based deformable image registration in 4DCT for tumor motion estimation in liver radiotherapy planning
title_full_unstemmed Accuracy and consistency of intensity-based deformable image registration in 4DCT for tumor motion estimation in liver radiotherapy planning
title_short Accuracy and consistency of intensity-based deformable image registration in 4DCT for tumor motion estimation in liver radiotherapy planning
title_sort accuracy and consistency of intensity-based deformable image registration in 4dct for tumor motion estimation in liver radiotherapy planning
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9269460/
https://www.ncbi.nlm.nih.gov/pubmed/35802593
http://dx.doi.org/10.1371/journal.pone.0271064
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