Model-based translation of DNA damage signaling dynamics across cell types

Interindividual variability in DNA damage response (DDR) dynamics may evoke differences in susceptibility to cancer. However, pathway dynamics are often studied in cell lines as alternative to primary cells, disregarding variability. To compare DDR dynamics in the cell line HepG2 with primary human...

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Detalles Bibliográficos
Autores principales: Heldring, Muriel M., Wijaya, Lukas S., Niemeijer, Marije, Yang, Huan, Lakhal, Talel, Le Dévédec, Sylvia E., van de Water, Bob, Beltman, Joost B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9269748/
https://www.ncbi.nlm.nih.gov/pubmed/35802572
http://dx.doi.org/10.1371/journal.pcbi.1010264

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