HP1 oligomerization compensates for low-affinity H3K9me recognition and provides a tunable mechanism for heterochromatin-specific localization

HP1 proteins traverse a complex and crowded chromatin landscape to bind with low affinity but high specificity to histone H3K9 methylation (H3K9me) and form transcriptionally inactive genomic compartments called heterochromatin. Here, we visualize single-molecule dynamics of an HP1 homolog, the fiss...

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Detalles Bibliográficos
Autores principales: Biswas, Saikat, Chen, Ziyuan, Karslake, Joshua D., Farhat, Ali, Ames, Amanda, Raiymbek, Gulzhan, Freddolino, Peter L., Biteen, Julie S., Ragunathan, Kaushik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9269880/
https://www.ncbi.nlm.nih.gov/pubmed/35857444
http://dx.doi.org/10.1126/sciadv.abk0793

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9269880/
https://www.ncbi.nlm.nih.gov/pubmed/35857444
http://dx.doi.org/10.1126/sciadv.abk0793

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