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A phospho-tyrosine–based signaling module using SPOP, CSK, and LYN controls TLR-induced IRF activity
Toll-like receptors (TLRs) recognize pathogen- and host-derived factors and control immune responses via the adaptor protein MyD88 and members of the interferon regulatory transcription factor (IRF) family. IRFs orchestrate key effector functions, including cytokine release, cell differentiation, an...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Association for the Advancement of Science
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9269885/ https://www.ncbi.nlm.nih.gov/pubmed/35857476 http://dx.doi.org/10.1126/sciadv.abq0084 |