Interrogating glioma-M2 macrophage interactions identifies Gal-9/Tim-3 as a viable target against PTEN-null glioblastoma

Genomic alteration can reshape tumor microenvironment to drive tumor malignancy. However, how PTEN deficiency influences microenvironment-mediated cell-cell interactions in glioblastoma (GBM) remains unclear. Here, we show that PTEN deficiency induces a symbiotic glioma-M2 macrophage interaction to...

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Detalles Bibliográficos
Autores principales: Ni, Xiangrong, Wu, Weichi, Sun, Xiaoqiang, Ma, Junxiao, Yu, Zhihui, He, Xinwei, Cheng, Jinyu, Xu, Pengfei, Liu, Haoxian, Shang, Tengze, Xi, Shaoyan, Wang, Jing, Zhang, Ji, Chen, Zhongping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9269888/
https://www.ncbi.nlm.nih.gov/pubmed/35857445
http://dx.doi.org/10.1126/sciadv.abl5165

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