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Data-based stochastic modeling reveals sources of activity bursts in single-cell TGF-β signaling

Cells sense their surrounding by employing intracellular signaling pathways that transmit hormonal signals from the cell membrane to the nucleus. TGF-β/SMAD signaling encodes various cell fates, controls tissue homeostasis and is deregulated in diseases such as cancer. The pathway shows strong heter...

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Detalles Bibliográficos
Autores principales:	Kolbe, Niklas, Hexemer, Lorenz, Bammert, Lukas-Malte, Loewer, Alexander, Lukáčová-Medvid’ová, Mária, Legewie, Stefan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9269928/ https://www.ncbi.nlm.nih.gov/pubmed/35759468 http://dx.doi.org/10.1371/journal.pcbi.1010266

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