Cargando…
Clinical and chest computed tomography features of patients suffering from mild and severe COVID-19 at Fayoum University Hospital in Egypt
BACKGROUND: In pandemic COVID-19 (coronavirus disease 2019), the prognosis of patients has been determined using clinical data and CT (computed tomography) scans, but it is still unclear whether chest CT characteristics are correlated to COVID-19 severity. AIM: To explore the potential association b...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9269943/ https://www.ncbi.nlm.nih.gov/pubmed/35802733 http://dx.doi.org/10.1371/journal.pone.0271271 |
_version_ | 1784744345329467392 |
---|---|
author | Ismail, Ahmed Doghish, Ahmed S. Elkhatib, Walid F. Magdy, Ahmed M. Mahmoud, Eman E. Ahmed, Mona I. Khalil, Mahmoud A. F. |
author_facet | Ismail, Ahmed Doghish, Ahmed S. Elkhatib, Walid F. Magdy, Ahmed M. Mahmoud, Eman E. Ahmed, Mona I. Khalil, Mahmoud A. F. |
author_sort | Ismail, Ahmed |
collection | PubMed |
description | BACKGROUND: In pandemic COVID-19 (coronavirus disease 2019), the prognosis of patients has been determined using clinical data and CT (computed tomography) scans, but it is still unclear whether chest CT characteristics are correlated to COVID-19 severity. AIM: To explore the potential association between clinical data and 25-point CT score and investigate their predictive significance in COVID-19-positive patients at Fayoum University Hospital in Egypt. METHODS: This study was conducted on 252 Egyptian COVID-19 patients at Fayoum University Hospital in Egypt. The patients were classified into two groups: a mild group (174 patients) and a severe group (78 patients). The results of clinical laboratory data, and CT scans of severe and mild patients, were collected, analyzed, and compared. RESULTS: The severe group show high significance levels of CRP, alanine aminotransferase (ALT), aspartate aminotransferase (AST), creatinine, urea, ferritin, lactate dehydrogenase (LDH), neutrophil percent, and heart rate (HR) than the mild group. Lymphopenia, hypoalbuminemia, hypocalcemia, and decreased oxygen saturation (SpO2) were the most observed abnormalities in severe COVID-19 patients. Lymphopenia, low SpO2 and albumin levels, elevated serum LDH, ferritin, urea, and CRP levels were found to be significantly correlated with severity CT score (P<0.0001). CONCLUSION: The clinical severity of COVID-19 and the CT score are highly correlated. Our findings indicate that the CT scoring system can help to predict COVID-19 disease outcomes and has a strong correlation with clinical laboratory testing. |
format | Online Article Text |
id | pubmed-9269943 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-92699432022-07-09 Clinical and chest computed tomography features of patients suffering from mild and severe COVID-19 at Fayoum University Hospital in Egypt Ismail, Ahmed Doghish, Ahmed S. Elkhatib, Walid F. Magdy, Ahmed M. Mahmoud, Eman E. Ahmed, Mona I. Khalil, Mahmoud A. F. PLoS One Research Article BACKGROUND: In pandemic COVID-19 (coronavirus disease 2019), the prognosis of patients has been determined using clinical data and CT (computed tomography) scans, but it is still unclear whether chest CT characteristics are correlated to COVID-19 severity. AIM: To explore the potential association between clinical data and 25-point CT score and investigate their predictive significance in COVID-19-positive patients at Fayoum University Hospital in Egypt. METHODS: This study was conducted on 252 Egyptian COVID-19 patients at Fayoum University Hospital in Egypt. The patients were classified into two groups: a mild group (174 patients) and a severe group (78 patients). The results of clinical laboratory data, and CT scans of severe and mild patients, were collected, analyzed, and compared. RESULTS: The severe group show high significance levels of CRP, alanine aminotransferase (ALT), aspartate aminotransferase (AST), creatinine, urea, ferritin, lactate dehydrogenase (LDH), neutrophil percent, and heart rate (HR) than the mild group. Lymphopenia, hypoalbuminemia, hypocalcemia, and decreased oxygen saturation (SpO2) were the most observed abnormalities in severe COVID-19 patients. Lymphopenia, low SpO2 and albumin levels, elevated serum LDH, ferritin, urea, and CRP levels were found to be significantly correlated with severity CT score (P<0.0001). CONCLUSION: The clinical severity of COVID-19 and the CT score are highly correlated. Our findings indicate that the CT scoring system can help to predict COVID-19 disease outcomes and has a strong correlation with clinical laboratory testing. Public Library of Science 2022-07-08 /pmc/articles/PMC9269943/ /pubmed/35802733 http://dx.doi.org/10.1371/journal.pone.0271271 Text en © 2022 Ismail et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Ismail, Ahmed Doghish, Ahmed S. Elkhatib, Walid F. Magdy, Ahmed M. Mahmoud, Eman E. Ahmed, Mona I. Khalil, Mahmoud A. F. Clinical and chest computed tomography features of patients suffering from mild and severe COVID-19 at Fayoum University Hospital in Egypt |
title | Clinical and chest computed tomography features of patients suffering from mild and severe COVID-19 at Fayoum University Hospital in Egypt |
title_full | Clinical and chest computed tomography features of patients suffering from mild and severe COVID-19 at Fayoum University Hospital in Egypt |
title_fullStr | Clinical and chest computed tomography features of patients suffering from mild and severe COVID-19 at Fayoum University Hospital in Egypt |
title_full_unstemmed | Clinical and chest computed tomography features of patients suffering from mild and severe COVID-19 at Fayoum University Hospital in Egypt |
title_short | Clinical and chest computed tomography features of patients suffering from mild and severe COVID-19 at Fayoum University Hospital in Egypt |
title_sort | clinical and chest computed tomography features of patients suffering from mild and severe covid-19 at fayoum university hospital in egypt |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9269943/ https://www.ncbi.nlm.nih.gov/pubmed/35802733 http://dx.doi.org/10.1371/journal.pone.0271271 |
work_keys_str_mv | AT ismailahmed clinicalandchestcomputedtomographyfeaturesofpatientssufferingfrommildandseverecovid19atfayoumuniversityhospitalinegypt AT doghishahmeds clinicalandchestcomputedtomographyfeaturesofpatientssufferingfrommildandseverecovid19atfayoumuniversityhospitalinegypt AT elkhatibwalidf clinicalandchestcomputedtomographyfeaturesofpatientssufferingfrommildandseverecovid19atfayoumuniversityhospitalinegypt AT magdyahmedm clinicalandchestcomputedtomographyfeaturesofpatientssufferingfrommildandseverecovid19atfayoumuniversityhospitalinegypt AT mahmoudemane clinicalandchestcomputedtomographyfeaturesofpatientssufferingfrommildandseverecovid19atfayoumuniversityhospitalinegypt AT ahmedmonai clinicalandchestcomputedtomographyfeaturesofpatientssufferingfrommildandseverecovid19atfayoumuniversityhospitalinegypt AT khalilmahmoudaf clinicalandchestcomputedtomographyfeaturesofpatientssufferingfrommildandseverecovid19atfayoumuniversityhospitalinegypt |