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Lifestyle and Dietary Habits Affect Plasma Levels of Specific Cytokines in Healthy Subjects

Low-grade chronic inflammation (LGCI) is a common feature of non-communicable diseases. Cytokines play a crucial role in LGCI. This study aimed to assess how LGCI risk factors [e.g., age, body mass index (BMI), smoke, physical activity, and diet] may impact on specific cytokine levels in a healthy p...

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Autores principales: D'Esposito, Vittoria, Di Tolla, Michele Francesco, Lecce, Manuela, Cavalli, Francesco, Libutti, Michele, Misso, Saverio, Cabaro, Serena, Ambrosio, Maria Rosaria, Parascandolo, Alessia, Covelli, Bianca, Perruolo, Giuseppe, Sansone, Mario, Formisano, Pietro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9270017/
https://www.ncbi.nlm.nih.gov/pubmed/35811952
http://dx.doi.org/10.3389/fnut.2022.913176
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author D'Esposito, Vittoria
Di Tolla, Michele Francesco
Lecce, Manuela
Cavalli, Francesco
Libutti, Michele
Misso, Saverio
Cabaro, Serena
Ambrosio, Maria Rosaria
Parascandolo, Alessia
Covelli, Bianca
Perruolo, Giuseppe
Sansone, Mario
Formisano, Pietro
author_facet D'Esposito, Vittoria
Di Tolla, Michele Francesco
Lecce, Manuela
Cavalli, Francesco
Libutti, Michele
Misso, Saverio
Cabaro, Serena
Ambrosio, Maria Rosaria
Parascandolo, Alessia
Covelli, Bianca
Perruolo, Giuseppe
Sansone, Mario
Formisano, Pietro
author_sort D'Esposito, Vittoria
collection PubMed
description Low-grade chronic inflammation (LGCI) is a common feature of non-communicable diseases. Cytokines play a crucial role in LGCI. This study aimed to assess how LGCI risk factors [e.g., age, body mass index (BMI), smoke, physical activity, and diet] may impact on specific cytokine levels in a healthy population. In total, 150 healthy volunteers were recruited and subjected to questionnaires about the last 7-day lifestyle, including smoking habit, physical activity, and food frequency. A panel of circulating cytokines, chemokines, and growth factors was analyzed by multiplex ELISA. BMI showed the heaviest impact on the correlation between LGCI-related risk factors and cytokines and was significantly associated with CRP levels. Aging was characterized by an increase in IL-1b, eotaxin, MCP-1, and MIP-1α. Smoking was related to higher levels of IL-1b and CCL5/RANTES, while physical activity was related to MIP-1α. Within the different eating habits, CRP levels were modulated by eggs, red meat, shelled fruits, and greens consumption; however, these associations were not confirmed in a multivariate model after adjusting for BMI. Nevertheless, red meat consumption was associated with an inflammatory pattern, characterized by an increase in IL-6 and IL-8. IL-8 levels were also increased with the frequent intake of sweets, while a higher intake of shelled fruits correlated with lower levels of IL-6. Moreover, IL-6 and IL-8 formed a cluster that also included IL-1b and TNF-α. In conclusion, age, BMI, smoke, physical activity, and dietary habits are associated with specific cytokines that may represent potential markers for LGCI.
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spelling pubmed-92700172022-07-09 Lifestyle and Dietary Habits Affect Plasma Levels of Specific Cytokines in Healthy Subjects D'Esposito, Vittoria Di Tolla, Michele Francesco Lecce, Manuela Cavalli, Francesco Libutti, Michele Misso, Saverio Cabaro, Serena Ambrosio, Maria Rosaria Parascandolo, Alessia Covelli, Bianca Perruolo, Giuseppe Sansone, Mario Formisano, Pietro Front Nutr Nutrition Low-grade chronic inflammation (LGCI) is a common feature of non-communicable diseases. Cytokines play a crucial role in LGCI. This study aimed to assess how LGCI risk factors [e.g., age, body mass index (BMI), smoke, physical activity, and diet] may impact on specific cytokine levels in a healthy population. In total, 150 healthy volunteers were recruited and subjected to questionnaires about the last 7-day lifestyle, including smoking habit, physical activity, and food frequency. A panel of circulating cytokines, chemokines, and growth factors was analyzed by multiplex ELISA. BMI showed the heaviest impact on the correlation between LGCI-related risk factors and cytokines and was significantly associated with CRP levels. Aging was characterized by an increase in IL-1b, eotaxin, MCP-1, and MIP-1α. Smoking was related to higher levels of IL-1b and CCL5/RANTES, while physical activity was related to MIP-1α. Within the different eating habits, CRP levels were modulated by eggs, red meat, shelled fruits, and greens consumption; however, these associations were not confirmed in a multivariate model after adjusting for BMI. Nevertheless, red meat consumption was associated with an inflammatory pattern, characterized by an increase in IL-6 and IL-8. IL-8 levels were also increased with the frequent intake of sweets, while a higher intake of shelled fruits correlated with lower levels of IL-6. Moreover, IL-6 and IL-8 formed a cluster that also included IL-1b and TNF-α. In conclusion, age, BMI, smoke, physical activity, and dietary habits are associated with specific cytokines that may represent potential markers for LGCI. Frontiers Media S.A. 2022-06-24 /pmc/articles/PMC9270017/ /pubmed/35811952 http://dx.doi.org/10.3389/fnut.2022.913176 Text en Copyright © 2022 D'Esposito, Di Tolla, Lecce, Cavalli, Libutti, Misso, Cabaro, Ambrosio, Parascandolo, Covelli, Perruolo, Sansone and Formisano. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Nutrition
D'Esposito, Vittoria
Di Tolla, Michele Francesco
Lecce, Manuela
Cavalli, Francesco
Libutti, Michele
Misso, Saverio
Cabaro, Serena
Ambrosio, Maria Rosaria
Parascandolo, Alessia
Covelli, Bianca
Perruolo, Giuseppe
Sansone, Mario
Formisano, Pietro
Lifestyle and Dietary Habits Affect Plasma Levels of Specific Cytokines in Healthy Subjects
title Lifestyle and Dietary Habits Affect Plasma Levels of Specific Cytokines in Healthy Subjects
title_full Lifestyle and Dietary Habits Affect Plasma Levels of Specific Cytokines in Healthy Subjects
title_fullStr Lifestyle and Dietary Habits Affect Plasma Levels of Specific Cytokines in Healthy Subjects
title_full_unstemmed Lifestyle and Dietary Habits Affect Plasma Levels of Specific Cytokines in Healthy Subjects
title_short Lifestyle and Dietary Habits Affect Plasma Levels of Specific Cytokines in Healthy Subjects
title_sort lifestyle and dietary habits affect plasma levels of specific cytokines in healthy subjects
topic Nutrition
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9270017/
https://www.ncbi.nlm.nih.gov/pubmed/35811952
http://dx.doi.org/10.3389/fnut.2022.913176
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