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Lifestyle and Dietary Habits Affect Plasma Levels of Specific Cytokines in Healthy Subjects
Low-grade chronic inflammation (LGCI) is a common feature of non-communicable diseases. Cytokines play a crucial role in LGCI. This study aimed to assess how LGCI risk factors [e.g., age, body mass index (BMI), smoke, physical activity, and diet] may impact on specific cytokine levels in a healthy p...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9270017/ https://www.ncbi.nlm.nih.gov/pubmed/35811952 http://dx.doi.org/10.3389/fnut.2022.913176 |
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author | D'Esposito, Vittoria Di Tolla, Michele Francesco Lecce, Manuela Cavalli, Francesco Libutti, Michele Misso, Saverio Cabaro, Serena Ambrosio, Maria Rosaria Parascandolo, Alessia Covelli, Bianca Perruolo, Giuseppe Sansone, Mario Formisano, Pietro |
author_facet | D'Esposito, Vittoria Di Tolla, Michele Francesco Lecce, Manuela Cavalli, Francesco Libutti, Michele Misso, Saverio Cabaro, Serena Ambrosio, Maria Rosaria Parascandolo, Alessia Covelli, Bianca Perruolo, Giuseppe Sansone, Mario Formisano, Pietro |
author_sort | D'Esposito, Vittoria |
collection | PubMed |
description | Low-grade chronic inflammation (LGCI) is a common feature of non-communicable diseases. Cytokines play a crucial role in LGCI. This study aimed to assess how LGCI risk factors [e.g., age, body mass index (BMI), smoke, physical activity, and diet] may impact on specific cytokine levels in a healthy population. In total, 150 healthy volunteers were recruited and subjected to questionnaires about the last 7-day lifestyle, including smoking habit, physical activity, and food frequency. A panel of circulating cytokines, chemokines, and growth factors was analyzed by multiplex ELISA. BMI showed the heaviest impact on the correlation between LGCI-related risk factors and cytokines and was significantly associated with CRP levels. Aging was characterized by an increase in IL-1b, eotaxin, MCP-1, and MIP-1α. Smoking was related to higher levels of IL-1b and CCL5/RANTES, while physical activity was related to MIP-1α. Within the different eating habits, CRP levels were modulated by eggs, red meat, shelled fruits, and greens consumption; however, these associations were not confirmed in a multivariate model after adjusting for BMI. Nevertheless, red meat consumption was associated with an inflammatory pattern, characterized by an increase in IL-6 and IL-8. IL-8 levels were also increased with the frequent intake of sweets, while a higher intake of shelled fruits correlated with lower levels of IL-6. Moreover, IL-6 and IL-8 formed a cluster that also included IL-1b and TNF-α. In conclusion, age, BMI, smoke, physical activity, and dietary habits are associated with specific cytokines that may represent potential markers for LGCI. |
format | Online Article Text |
id | pubmed-9270017 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-92700172022-07-09 Lifestyle and Dietary Habits Affect Plasma Levels of Specific Cytokines in Healthy Subjects D'Esposito, Vittoria Di Tolla, Michele Francesco Lecce, Manuela Cavalli, Francesco Libutti, Michele Misso, Saverio Cabaro, Serena Ambrosio, Maria Rosaria Parascandolo, Alessia Covelli, Bianca Perruolo, Giuseppe Sansone, Mario Formisano, Pietro Front Nutr Nutrition Low-grade chronic inflammation (LGCI) is a common feature of non-communicable diseases. Cytokines play a crucial role in LGCI. This study aimed to assess how LGCI risk factors [e.g., age, body mass index (BMI), smoke, physical activity, and diet] may impact on specific cytokine levels in a healthy population. In total, 150 healthy volunteers were recruited and subjected to questionnaires about the last 7-day lifestyle, including smoking habit, physical activity, and food frequency. A panel of circulating cytokines, chemokines, and growth factors was analyzed by multiplex ELISA. BMI showed the heaviest impact on the correlation between LGCI-related risk factors and cytokines and was significantly associated with CRP levels. Aging was characterized by an increase in IL-1b, eotaxin, MCP-1, and MIP-1α. Smoking was related to higher levels of IL-1b and CCL5/RANTES, while physical activity was related to MIP-1α. Within the different eating habits, CRP levels were modulated by eggs, red meat, shelled fruits, and greens consumption; however, these associations were not confirmed in a multivariate model after adjusting for BMI. Nevertheless, red meat consumption was associated with an inflammatory pattern, characterized by an increase in IL-6 and IL-8. IL-8 levels were also increased with the frequent intake of sweets, while a higher intake of shelled fruits correlated with lower levels of IL-6. Moreover, IL-6 and IL-8 formed a cluster that also included IL-1b and TNF-α. In conclusion, age, BMI, smoke, physical activity, and dietary habits are associated with specific cytokines that may represent potential markers for LGCI. Frontiers Media S.A. 2022-06-24 /pmc/articles/PMC9270017/ /pubmed/35811952 http://dx.doi.org/10.3389/fnut.2022.913176 Text en Copyright © 2022 D'Esposito, Di Tolla, Lecce, Cavalli, Libutti, Misso, Cabaro, Ambrosio, Parascandolo, Covelli, Perruolo, Sansone and Formisano. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Nutrition D'Esposito, Vittoria Di Tolla, Michele Francesco Lecce, Manuela Cavalli, Francesco Libutti, Michele Misso, Saverio Cabaro, Serena Ambrosio, Maria Rosaria Parascandolo, Alessia Covelli, Bianca Perruolo, Giuseppe Sansone, Mario Formisano, Pietro Lifestyle and Dietary Habits Affect Plasma Levels of Specific Cytokines in Healthy Subjects |
title | Lifestyle and Dietary Habits Affect Plasma Levels of Specific Cytokines in Healthy Subjects |
title_full | Lifestyle and Dietary Habits Affect Plasma Levels of Specific Cytokines in Healthy Subjects |
title_fullStr | Lifestyle and Dietary Habits Affect Plasma Levels of Specific Cytokines in Healthy Subjects |
title_full_unstemmed | Lifestyle and Dietary Habits Affect Plasma Levels of Specific Cytokines in Healthy Subjects |
title_short | Lifestyle and Dietary Habits Affect Plasma Levels of Specific Cytokines in Healthy Subjects |
title_sort | lifestyle and dietary habits affect plasma levels of specific cytokines in healthy subjects |
topic | Nutrition |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9270017/ https://www.ncbi.nlm.nih.gov/pubmed/35811952 http://dx.doi.org/10.3389/fnut.2022.913176 |
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