Metformin abrogates pathological TNF-α-producing B cells through mTOR-dependent metabolic reprogramming in polycystic ovary syndrome

B cells contribute to the pathogenesis of polycystic ovary syndrome (PCOS). Clinically, metformin is used to treat PCOS, but it is unclear whether metformin exerts its therapeutic effect by regulating B cells. Here, we showed that the expression level of tumor necrosis factor-alpha (TNF-α) in periph...

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Detalles Bibliográficos
Autores principales: Xiao, Na, Wang, Jie, Wang, Ting, Xiong, Xingliang, Zhou, Junyi, Su, Xian, Peng, Jing, Yang, Chao, Li, Xiaofeng, Lin, Ge, Lu, Guangxiu, Gong, Fei, Cheng, Lamei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Immunology and Inflammation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9270024/
https://www.ncbi.nlm.nih.gov/pubmed/35748536
http://dx.doi.org/10.7554/eLife.74713

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