Cargando…

Plasma and memory antibody responses to Gamma SARS-CoV-2 provide limited cross-protection to other variants

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to be a global problem in part because of the emergence of variants of concern that evade neutralization by antibodies elicited by prior infection or vaccination. Here we report on human neutralizing antibody and memory responses...

Descripción completa

Detalles Bibliográficos
Autores principales: Agudelo, Marianna, Muecksch, Frauke, Schaefer-Babajew, Dennis, Cho, Alice, DaSilva, Justin, Bednarski, Eva, Ramos, Victor, Oliveira, Thiago Y., Cipolla, Melissa, Gazumyan, Anna, Zong, Shuai, Rodrigues, Danielle A.S., Lira, Guilherme S., Conde, Luciana, Aguiar, Renato Santana, Ferreira, Orlando C., Tanuri, Amilcar, Affonso, Katia C., Galliez, Rafael M., Castineiras, Terezinha Marta Pereira Pinto, Echevarria-Lima, Juliana, Bozza, Marcelo Torres, Vale, Andre M., Bieniasz, Paul D., Hatziioannou, Theodora, Nussenzweig, Michel C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9270183/
https://www.ncbi.nlm.nih.gov/pubmed/35796685
http://dx.doi.org/10.1084/jem.20220367
_version_ 1784744404589740032
author Agudelo, Marianna
Muecksch, Frauke
Schaefer-Babajew, Dennis
Cho, Alice
DaSilva, Justin
Bednarski, Eva
Ramos, Victor
Oliveira, Thiago Y.
Cipolla, Melissa
Gazumyan, Anna
Zong, Shuai
Rodrigues, Danielle A.S.
Lira, Guilherme S.
Conde, Luciana
Aguiar, Renato Santana
Ferreira, Orlando C.
Tanuri, Amilcar
Affonso, Katia C.
Galliez, Rafael M.
Castineiras, Terezinha Marta Pereira Pinto
Echevarria-Lima, Juliana
Bozza, Marcelo Torres
Vale, Andre M.
Bieniasz, Paul D.
Hatziioannou, Theodora
Nussenzweig, Michel C.
author_facet Agudelo, Marianna
Muecksch, Frauke
Schaefer-Babajew, Dennis
Cho, Alice
DaSilva, Justin
Bednarski, Eva
Ramos, Victor
Oliveira, Thiago Y.
Cipolla, Melissa
Gazumyan, Anna
Zong, Shuai
Rodrigues, Danielle A.S.
Lira, Guilherme S.
Conde, Luciana
Aguiar, Renato Santana
Ferreira, Orlando C.
Tanuri, Amilcar
Affonso, Katia C.
Galliez, Rafael M.
Castineiras, Terezinha Marta Pereira Pinto
Echevarria-Lima, Juliana
Bozza, Marcelo Torres
Vale, Andre M.
Bieniasz, Paul D.
Hatziioannou, Theodora
Nussenzweig, Michel C.
author_sort Agudelo, Marianna
collection PubMed
description Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to be a global problem in part because of the emergence of variants of concern that evade neutralization by antibodies elicited by prior infection or vaccination. Here we report on human neutralizing antibody and memory responses to the Gamma variant in a cohort of hospitalized individuals. Plasma from infected individuals potently neutralized viruses pseudotyped with Gamma SARS-CoV-2 spike protein, but neutralizing activity against Wuhan-Hu-1-1, Beta, Delta, or Omicron was significantly lower. Monoclonal antibodies from memory B cells also neutralized Gamma and Beta pseudoviruses more effectively than Wuhan-Hu-1. 69% and 34% of Gamma-neutralizing antibodies failed to neutralize Delta or Wuhan-Hu-1. Although Class 1 and 2 antibodies dominate the response to Wuhan-Hu-1 or Beta, 54% of antibodies elicited by Gamma infection recognized Class 3 epitopes. The results have implications for variant-specific vaccines and infections, suggesting that exposure to variants generally provides more limited protection to other variants.
format Online
Article
Text
id pubmed-9270183
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Rockefeller University Press
record_format MEDLINE/PubMed
spelling pubmed-92701832022-08-16 Plasma and memory antibody responses to Gamma SARS-CoV-2 provide limited cross-protection to other variants Agudelo, Marianna Muecksch, Frauke Schaefer-Babajew, Dennis Cho, Alice DaSilva, Justin Bednarski, Eva Ramos, Victor Oliveira, Thiago Y. Cipolla, Melissa Gazumyan, Anna Zong, Shuai Rodrigues, Danielle A.S. Lira, Guilherme S. Conde, Luciana Aguiar, Renato Santana Ferreira, Orlando C. Tanuri, Amilcar Affonso, Katia C. Galliez, Rafael M. Castineiras, Terezinha Marta Pereira Pinto Echevarria-Lima, Juliana Bozza, Marcelo Torres Vale, Andre M. Bieniasz, Paul D. Hatziioannou, Theodora Nussenzweig, Michel C. J Exp Med Article Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to be a global problem in part because of the emergence of variants of concern that evade neutralization by antibodies elicited by prior infection or vaccination. Here we report on human neutralizing antibody and memory responses to the Gamma variant in a cohort of hospitalized individuals. Plasma from infected individuals potently neutralized viruses pseudotyped with Gamma SARS-CoV-2 spike protein, but neutralizing activity against Wuhan-Hu-1-1, Beta, Delta, or Omicron was significantly lower. Monoclonal antibodies from memory B cells also neutralized Gamma and Beta pseudoviruses more effectively than Wuhan-Hu-1. 69% and 34% of Gamma-neutralizing antibodies failed to neutralize Delta or Wuhan-Hu-1. Although Class 1 and 2 antibodies dominate the response to Wuhan-Hu-1 or Beta, 54% of antibodies elicited by Gamma infection recognized Class 3 epitopes. The results have implications for variant-specific vaccines and infections, suggesting that exposure to variants generally provides more limited protection to other variants. Rockefeller University Press 2022-07-07 /pmc/articles/PMC9270183/ /pubmed/35796685 http://dx.doi.org/10.1084/jem.20220367 Text en © 2022 Agudelo et al. https://creativecommons.org/licenses/by/4.0/This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Agudelo, Marianna
Muecksch, Frauke
Schaefer-Babajew, Dennis
Cho, Alice
DaSilva, Justin
Bednarski, Eva
Ramos, Victor
Oliveira, Thiago Y.
Cipolla, Melissa
Gazumyan, Anna
Zong, Shuai
Rodrigues, Danielle A.S.
Lira, Guilherme S.
Conde, Luciana
Aguiar, Renato Santana
Ferreira, Orlando C.
Tanuri, Amilcar
Affonso, Katia C.
Galliez, Rafael M.
Castineiras, Terezinha Marta Pereira Pinto
Echevarria-Lima, Juliana
Bozza, Marcelo Torres
Vale, Andre M.
Bieniasz, Paul D.
Hatziioannou, Theodora
Nussenzweig, Michel C.
Plasma and memory antibody responses to Gamma SARS-CoV-2 provide limited cross-protection to other variants
title Plasma and memory antibody responses to Gamma SARS-CoV-2 provide limited cross-protection to other variants
title_full Plasma and memory antibody responses to Gamma SARS-CoV-2 provide limited cross-protection to other variants
title_fullStr Plasma and memory antibody responses to Gamma SARS-CoV-2 provide limited cross-protection to other variants
title_full_unstemmed Plasma and memory antibody responses to Gamma SARS-CoV-2 provide limited cross-protection to other variants
title_short Plasma and memory antibody responses to Gamma SARS-CoV-2 provide limited cross-protection to other variants
title_sort plasma and memory antibody responses to gamma sars-cov-2 provide limited cross-protection to other variants
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9270183/
https://www.ncbi.nlm.nih.gov/pubmed/35796685
http://dx.doi.org/10.1084/jem.20220367
work_keys_str_mv AT agudelomarianna plasmaandmemoryantibodyresponsestogammasarscov2providelimitedcrossprotectiontoothervariants
AT mueckschfrauke plasmaandmemoryantibodyresponsestogammasarscov2providelimitedcrossprotectiontoothervariants
AT schaeferbabajewdennis plasmaandmemoryantibodyresponsestogammasarscov2providelimitedcrossprotectiontoothervariants
AT choalice plasmaandmemoryantibodyresponsestogammasarscov2providelimitedcrossprotectiontoothervariants
AT dasilvajustin plasmaandmemoryantibodyresponsestogammasarscov2providelimitedcrossprotectiontoothervariants
AT bednarskieva plasmaandmemoryantibodyresponsestogammasarscov2providelimitedcrossprotectiontoothervariants
AT ramosvictor plasmaandmemoryantibodyresponsestogammasarscov2providelimitedcrossprotectiontoothervariants
AT oliveirathiagoy plasmaandmemoryantibodyresponsestogammasarscov2providelimitedcrossprotectiontoothervariants
AT cipollamelissa plasmaandmemoryantibodyresponsestogammasarscov2providelimitedcrossprotectiontoothervariants
AT gazumyananna plasmaandmemoryantibodyresponsestogammasarscov2providelimitedcrossprotectiontoothervariants
AT zongshuai plasmaandmemoryantibodyresponsestogammasarscov2providelimitedcrossprotectiontoothervariants
AT rodriguesdanielleas plasmaandmemoryantibodyresponsestogammasarscov2providelimitedcrossprotectiontoothervariants
AT liraguilhermes plasmaandmemoryantibodyresponsestogammasarscov2providelimitedcrossprotectiontoothervariants
AT condeluciana plasmaandmemoryantibodyresponsestogammasarscov2providelimitedcrossprotectiontoothervariants
AT aguiarrenatosantana plasmaandmemoryantibodyresponsestogammasarscov2providelimitedcrossprotectiontoothervariants
AT ferreiraorlandoc plasmaandmemoryantibodyresponsestogammasarscov2providelimitedcrossprotectiontoothervariants
AT tanuriamilcar plasmaandmemoryantibodyresponsestogammasarscov2providelimitedcrossprotectiontoothervariants
AT affonsokatiac plasmaandmemoryantibodyresponsestogammasarscov2providelimitedcrossprotectiontoothervariants
AT galliezrafaelm plasmaandmemoryantibodyresponsestogammasarscov2providelimitedcrossprotectiontoothervariants
AT castineirasterezinhamartapereirapinto plasmaandmemoryantibodyresponsestogammasarscov2providelimitedcrossprotectiontoothervariants
AT echevarrialimajuliana plasmaandmemoryantibodyresponsestogammasarscov2providelimitedcrossprotectiontoothervariants
AT bozzamarcelotorres plasmaandmemoryantibodyresponsestogammasarscov2providelimitedcrossprotectiontoothervariants
AT valeandrem plasmaandmemoryantibodyresponsestogammasarscov2providelimitedcrossprotectiontoothervariants
AT bieniaszpauld plasmaandmemoryantibodyresponsestogammasarscov2providelimitedcrossprotectiontoothervariants
AT hatziioannoutheodora plasmaandmemoryantibodyresponsestogammasarscov2providelimitedcrossprotectiontoothervariants
AT nussenzweigmichelc plasmaandmemoryantibodyresponsestogammasarscov2providelimitedcrossprotectiontoothervariants