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Plasma and memory antibody responses to Gamma SARS-CoV-2 provide limited cross-protection to other variants
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to be a global problem in part because of the emergence of variants of concern that evade neutralization by antibodies elicited by prior infection or vaccination. Here we report on human neutralizing antibody and memory responses...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Rockefeller University Press
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9270183/ https://www.ncbi.nlm.nih.gov/pubmed/35796685 http://dx.doi.org/10.1084/jem.20220367 |
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author | Agudelo, Marianna Muecksch, Frauke Schaefer-Babajew, Dennis Cho, Alice DaSilva, Justin Bednarski, Eva Ramos, Victor Oliveira, Thiago Y. Cipolla, Melissa Gazumyan, Anna Zong, Shuai Rodrigues, Danielle A.S. Lira, Guilherme S. Conde, Luciana Aguiar, Renato Santana Ferreira, Orlando C. Tanuri, Amilcar Affonso, Katia C. Galliez, Rafael M. Castineiras, Terezinha Marta Pereira Pinto Echevarria-Lima, Juliana Bozza, Marcelo Torres Vale, Andre M. Bieniasz, Paul D. Hatziioannou, Theodora Nussenzweig, Michel C. |
author_facet | Agudelo, Marianna Muecksch, Frauke Schaefer-Babajew, Dennis Cho, Alice DaSilva, Justin Bednarski, Eva Ramos, Victor Oliveira, Thiago Y. Cipolla, Melissa Gazumyan, Anna Zong, Shuai Rodrigues, Danielle A.S. Lira, Guilherme S. Conde, Luciana Aguiar, Renato Santana Ferreira, Orlando C. Tanuri, Amilcar Affonso, Katia C. Galliez, Rafael M. Castineiras, Terezinha Marta Pereira Pinto Echevarria-Lima, Juliana Bozza, Marcelo Torres Vale, Andre M. Bieniasz, Paul D. Hatziioannou, Theodora Nussenzweig, Michel C. |
author_sort | Agudelo, Marianna |
collection | PubMed |
description | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to be a global problem in part because of the emergence of variants of concern that evade neutralization by antibodies elicited by prior infection or vaccination. Here we report on human neutralizing antibody and memory responses to the Gamma variant in a cohort of hospitalized individuals. Plasma from infected individuals potently neutralized viruses pseudotyped with Gamma SARS-CoV-2 spike protein, but neutralizing activity against Wuhan-Hu-1-1, Beta, Delta, or Omicron was significantly lower. Monoclonal antibodies from memory B cells also neutralized Gamma and Beta pseudoviruses more effectively than Wuhan-Hu-1. 69% and 34% of Gamma-neutralizing antibodies failed to neutralize Delta or Wuhan-Hu-1. Although Class 1 and 2 antibodies dominate the response to Wuhan-Hu-1 or Beta, 54% of antibodies elicited by Gamma infection recognized Class 3 epitopes. The results have implications for variant-specific vaccines and infections, suggesting that exposure to variants generally provides more limited protection to other variants. |
format | Online Article Text |
id | pubmed-9270183 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-92701832022-08-16 Plasma and memory antibody responses to Gamma SARS-CoV-2 provide limited cross-protection to other variants Agudelo, Marianna Muecksch, Frauke Schaefer-Babajew, Dennis Cho, Alice DaSilva, Justin Bednarski, Eva Ramos, Victor Oliveira, Thiago Y. Cipolla, Melissa Gazumyan, Anna Zong, Shuai Rodrigues, Danielle A.S. Lira, Guilherme S. Conde, Luciana Aguiar, Renato Santana Ferreira, Orlando C. Tanuri, Amilcar Affonso, Katia C. Galliez, Rafael M. Castineiras, Terezinha Marta Pereira Pinto Echevarria-Lima, Juliana Bozza, Marcelo Torres Vale, Andre M. Bieniasz, Paul D. Hatziioannou, Theodora Nussenzweig, Michel C. J Exp Med Article Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to be a global problem in part because of the emergence of variants of concern that evade neutralization by antibodies elicited by prior infection or vaccination. Here we report on human neutralizing antibody and memory responses to the Gamma variant in a cohort of hospitalized individuals. Plasma from infected individuals potently neutralized viruses pseudotyped with Gamma SARS-CoV-2 spike protein, but neutralizing activity against Wuhan-Hu-1-1, Beta, Delta, or Omicron was significantly lower. Monoclonal antibodies from memory B cells also neutralized Gamma and Beta pseudoviruses more effectively than Wuhan-Hu-1. 69% and 34% of Gamma-neutralizing antibodies failed to neutralize Delta or Wuhan-Hu-1. Although Class 1 and 2 antibodies dominate the response to Wuhan-Hu-1 or Beta, 54% of antibodies elicited by Gamma infection recognized Class 3 epitopes. The results have implications for variant-specific vaccines and infections, suggesting that exposure to variants generally provides more limited protection to other variants. Rockefeller University Press 2022-07-07 /pmc/articles/PMC9270183/ /pubmed/35796685 http://dx.doi.org/10.1084/jem.20220367 Text en © 2022 Agudelo et al. https://creativecommons.org/licenses/by/4.0/This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Agudelo, Marianna Muecksch, Frauke Schaefer-Babajew, Dennis Cho, Alice DaSilva, Justin Bednarski, Eva Ramos, Victor Oliveira, Thiago Y. Cipolla, Melissa Gazumyan, Anna Zong, Shuai Rodrigues, Danielle A.S. Lira, Guilherme S. Conde, Luciana Aguiar, Renato Santana Ferreira, Orlando C. Tanuri, Amilcar Affonso, Katia C. Galliez, Rafael M. Castineiras, Terezinha Marta Pereira Pinto Echevarria-Lima, Juliana Bozza, Marcelo Torres Vale, Andre M. Bieniasz, Paul D. Hatziioannou, Theodora Nussenzweig, Michel C. Plasma and memory antibody responses to Gamma SARS-CoV-2 provide limited cross-protection to other variants |
title | Plasma and memory antibody responses to Gamma SARS-CoV-2 provide limited cross-protection to other variants |
title_full | Plasma and memory antibody responses to Gamma SARS-CoV-2 provide limited cross-protection to other variants |
title_fullStr | Plasma and memory antibody responses to Gamma SARS-CoV-2 provide limited cross-protection to other variants |
title_full_unstemmed | Plasma and memory antibody responses to Gamma SARS-CoV-2 provide limited cross-protection to other variants |
title_short | Plasma and memory antibody responses to Gamma SARS-CoV-2 provide limited cross-protection to other variants |
title_sort | plasma and memory antibody responses to gamma sars-cov-2 provide limited cross-protection to other variants |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9270183/ https://www.ncbi.nlm.nih.gov/pubmed/35796685 http://dx.doi.org/10.1084/jem.20220367 |
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