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Changes in body composition in patients with malignant pleural mesothelioma and the relationship with activity levels and dietary intake

BACKGROUND: Skeletal muscle loss is common in advanced cancer and is associated with negative outcomes. In malignant pleural mesothelioma (MPM), no study has reported body composition changes or factors associated with these changes. This study aimed to describe changes in body composition over time...

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Autores principales: Jeffery, Emily, Lee, Y. C. Gary, Newton, Robert U., Lyons-Wall, Philippa, McVeigh, Joanne, Fitzgerald, Deirdre B., Straker, Leon, Peddle-McIntyre, Carolyn J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9270221/
https://www.ncbi.nlm.nih.gov/pubmed/35039629
http://dx.doi.org/10.1038/s41430-021-01062-6
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author Jeffery, Emily
Lee, Y. C. Gary
Newton, Robert U.
Lyons-Wall, Philippa
McVeigh, Joanne
Fitzgerald, Deirdre B.
Straker, Leon
Peddle-McIntyre, Carolyn J.
author_facet Jeffery, Emily
Lee, Y. C. Gary
Newton, Robert U.
Lyons-Wall, Philippa
McVeigh, Joanne
Fitzgerald, Deirdre B.
Straker, Leon
Peddle-McIntyre, Carolyn J.
author_sort Jeffery, Emily
collection PubMed
description BACKGROUND: Skeletal muscle loss is common in advanced cancer and is associated with negative outcomes. In malignant pleural mesothelioma (MPM), no study has reported body composition changes or factors associated with these changes. This study aimed to describe changes in body composition over time and its relationship with activity levels, dietary intake and survival. METHODS: The study was a secondary analysis of data collected from a longitudinal observational study of patients with MPM. Participants completed 3-month assessments for up to 18 months. Participants with two dual-energy x-ray absorptiometry (DXA) scans were included. Changes in appendicular skeletal muscle mass (ASM) and total fat mass were used to categorise participants into phenotypes. Activity levels were measured with an ActiGraph GT3X+ accelerometer and energy and protein intake was measured with a 3-day food record and 24-h recall. RESULTS: Eighteen participants were included (89% men, mean age 68.9 ± 7.1 years). Median time between DXA was 91 [IQR 84–118] days. Compared to participants with ASM maintenance (n = 9), fewer participants with ASM loss (n = 9) survived ≥12 months from follow-up (p = 0.002). Participants with ASM loss increased sedentary time (p = 0.028) and decreased light activity (p = 0.028) and step count (p = 0.008). Activity levels did not change in participants with ASM maintenance (p > 0.05). Energy and protein intake did not change in either group (p > 0.05). CONCLUSIONS: Muscle loss was associated with poorer survival and decreased activity levels. Interventions that improve physical activity or muscle mass could benefit patients with MPM.
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spelling pubmed-92702212022-07-10 Changes in body composition in patients with malignant pleural mesothelioma and the relationship with activity levels and dietary intake Jeffery, Emily Lee, Y. C. Gary Newton, Robert U. Lyons-Wall, Philippa McVeigh, Joanne Fitzgerald, Deirdre B. Straker, Leon Peddle-McIntyre, Carolyn J. Eur J Clin Nutr Article BACKGROUND: Skeletal muscle loss is common in advanced cancer and is associated with negative outcomes. In malignant pleural mesothelioma (MPM), no study has reported body composition changes or factors associated with these changes. This study aimed to describe changes in body composition over time and its relationship with activity levels, dietary intake and survival. METHODS: The study was a secondary analysis of data collected from a longitudinal observational study of patients with MPM. Participants completed 3-month assessments for up to 18 months. Participants with two dual-energy x-ray absorptiometry (DXA) scans were included. Changes in appendicular skeletal muscle mass (ASM) and total fat mass were used to categorise participants into phenotypes. Activity levels were measured with an ActiGraph GT3X+ accelerometer and energy and protein intake was measured with a 3-day food record and 24-h recall. RESULTS: Eighteen participants were included (89% men, mean age 68.9 ± 7.1 years). Median time between DXA was 91 [IQR 84–118] days. Compared to participants with ASM maintenance (n = 9), fewer participants with ASM loss (n = 9) survived ≥12 months from follow-up (p = 0.002). Participants with ASM loss increased sedentary time (p = 0.028) and decreased light activity (p = 0.028) and step count (p = 0.008). Activity levels did not change in participants with ASM maintenance (p > 0.05). Energy and protein intake did not change in either group (p > 0.05). CONCLUSIONS: Muscle loss was associated with poorer survival and decreased activity levels. Interventions that improve physical activity or muscle mass could benefit patients with MPM. Nature Publishing Group UK 2022-01-17 2022 /pmc/articles/PMC9270221/ /pubmed/35039629 http://dx.doi.org/10.1038/s41430-021-01062-6 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Jeffery, Emily
Lee, Y. C. Gary
Newton, Robert U.
Lyons-Wall, Philippa
McVeigh, Joanne
Fitzgerald, Deirdre B.
Straker, Leon
Peddle-McIntyre, Carolyn J.
Changes in body composition in patients with malignant pleural mesothelioma and the relationship with activity levels and dietary intake
title Changes in body composition in patients with malignant pleural mesothelioma and the relationship with activity levels and dietary intake
title_full Changes in body composition in patients with malignant pleural mesothelioma and the relationship with activity levels and dietary intake
title_fullStr Changes in body composition in patients with malignant pleural mesothelioma and the relationship with activity levels and dietary intake
title_full_unstemmed Changes in body composition in patients with malignant pleural mesothelioma and the relationship with activity levels and dietary intake
title_short Changes in body composition in patients with malignant pleural mesothelioma and the relationship with activity levels and dietary intake
title_sort changes in body composition in patients with malignant pleural mesothelioma and the relationship with activity levels and dietary intake
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9270221/
https://www.ncbi.nlm.nih.gov/pubmed/35039629
http://dx.doi.org/10.1038/s41430-021-01062-6
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