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Elesclomol elevates cellular and mitochondrial iron levels by delivering copper to the iron import machinery
Copper (Cu) and iron (Fe) are redox-active metals that serve as cofactors for many essential cellular enzymes. Disruption in the intracellular homeostasis of these metals results in debilitating and frequently fatal human disorders, such as Menkes disease and Friedreich’s ataxia. Recently, we report...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9270252/ https://www.ncbi.nlm.nih.gov/pubmed/35714767 http://dx.doi.org/10.1016/j.jbc.2022.102139 |