Kv1.5 channel mediates monosodium urate-induced activation of NLRP3 inflammasome in macrophages and arrhythmogenic effects of urate on cardiomyocytes

BACKGROUND: Gout is usually found in patients with atrial fibrillation (AF). K+ efflux is a common trigger of NLRP3 inflammasome activation which is involved in the pathogenesis of AF. We investigated the role of the K+ channel Kv1.5 in monosodium urate crystal (MSU)-induced activation of the NLRP3...

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Detalles Bibliográficos
Autores principales: Li, Peili, Kurata, Yasutaka, Taufiq, Fikri, Kuwabara, Masanari, Ninomiya, Haruaki, Higaki, Katsumi, Tsuneto, Motokazu, Shirayoshi, Yasuaki, Lanaspa, Miguel A., Hisatome, Ichiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9270276/
https://www.ncbi.nlm.nih.gov/pubmed/35368226
http://dx.doi.org/10.1007/s11033-022-07378-1

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