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High levels of NRF2 sensitize temozolomide-resistant glioblastoma cells to ferroptosis via ABCC1/MRP1 upregulation

Glioblastoma patients have a poor prognosis mainly due to temozolomide (TMZ) resistance. NRF2 is an important transcript factor involved in chemotherapy resistance due to its protective role in the transcription of genes involved in cellular detoxification and prevention of cell death processes, suc...

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Detalles Bibliográficos
Autores principales:	de Souza, I., Monteiro, L. K. S., Guedes, C. B., Silva, M. M., Andrade-Tomaz, M., Contieri, B., Latancia, M. T., Mendes, D., Porchia, B. F. M. M., Lazarini, M., Gomes, L. R., Rocha, C. R. R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9270336/ https://www.ncbi.nlm.nih.gov/pubmed/35803910 http://dx.doi.org/10.1038/s41419-022-05044-9

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