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Temperature elevations can induce switches to homoclinic action potentials that alter neural encoding and synchronization

Almost seventy years after the discovery of the mechanisms of action potential generation, some aspects of their computational consequences are still not fully understood. Based on mathematical modeling, we here explore a type of action potential dynamics – arising from a saddle-node homoclinic orbi...

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Autores principales: Hesse, Janina, Schleimer, Jan-Hendrik, Maier, Nikolaus, Schmitz, Dietmar, Schreiber, Susanne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9270341/
https://www.ncbi.nlm.nih.gov/pubmed/35803913
http://dx.doi.org/10.1038/s41467-022-31195-6
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author Hesse, Janina
Schleimer, Jan-Hendrik
Maier, Nikolaus
Schmitz, Dietmar
Schreiber, Susanne
author_facet Hesse, Janina
Schleimer, Jan-Hendrik
Maier, Nikolaus
Schmitz, Dietmar
Schreiber, Susanne
author_sort Hesse, Janina
collection PubMed
description Almost seventy years after the discovery of the mechanisms of action potential generation, some aspects of their computational consequences are still not fully understood. Based on mathematical modeling, we here explore a type of action potential dynamics – arising from a saddle-node homoclinic orbit bifurcation - that so far has received little attention. We show that this type of dynamics is to be expected by specific changes in common physiological parameters, like an elevation of temperature. Moreover, we demonstrate that it favours synchronization patterns in networks – a feature that becomes particularly prominent when system parameters change such that homoclinic spiking is induced. Supported by in-vitro hallmarks for homoclinic spikes in the rodent brain, we hypothesize that the prevalence of homoclinic spikes in the brain may be underestimated and provide a missing link between the impact of biophysical parameters on abrupt transitions between asynchronous and synchronous states of electrical activity in the brain.
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spelling pubmed-92703412022-07-10 Temperature elevations can induce switches to homoclinic action potentials that alter neural encoding and synchronization Hesse, Janina Schleimer, Jan-Hendrik Maier, Nikolaus Schmitz, Dietmar Schreiber, Susanne Nat Commun Article Almost seventy years after the discovery of the mechanisms of action potential generation, some aspects of their computational consequences are still not fully understood. Based on mathematical modeling, we here explore a type of action potential dynamics – arising from a saddle-node homoclinic orbit bifurcation - that so far has received little attention. We show that this type of dynamics is to be expected by specific changes in common physiological parameters, like an elevation of temperature. Moreover, we demonstrate that it favours synchronization patterns in networks – a feature that becomes particularly prominent when system parameters change such that homoclinic spiking is induced. Supported by in-vitro hallmarks for homoclinic spikes in the rodent brain, we hypothesize that the prevalence of homoclinic spikes in the brain may be underestimated and provide a missing link between the impact of biophysical parameters on abrupt transitions between asynchronous and synchronous states of electrical activity in the brain. Nature Publishing Group UK 2022-07-08 /pmc/articles/PMC9270341/ /pubmed/35803913 http://dx.doi.org/10.1038/s41467-022-31195-6 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Hesse, Janina
Schleimer, Jan-Hendrik
Maier, Nikolaus
Schmitz, Dietmar
Schreiber, Susanne
Temperature elevations can induce switches to homoclinic action potentials that alter neural encoding and synchronization
title Temperature elevations can induce switches to homoclinic action potentials that alter neural encoding and synchronization
title_full Temperature elevations can induce switches to homoclinic action potentials that alter neural encoding and synchronization
title_fullStr Temperature elevations can induce switches to homoclinic action potentials that alter neural encoding and synchronization
title_full_unstemmed Temperature elevations can induce switches to homoclinic action potentials that alter neural encoding and synchronization
title_short Temperature elevations can induce switches to homoclinic action potentials that alter neural encoding and synchronization
title_sort temperature elevations can induce switches to homoclinic action potentials that alter neural encoding and synchronization
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9270341/
https://www.ncbi.nlm.nih.gov/pubmed/35803913
http://dx.doi.org/10.1038/s41467-022-31195-6
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