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Identification of the major photodegradant in metronidazole by LC-PDA-MS and its reveal in compendial methods

Metronidazole in aqueous solution is sensitive to light and UV irradiation, leading to the formation of N-(2-hydroxyethyl)-5-methyl-l,2,4-oxadiazole-3-carboxamide. This is revealed here by liquid chromatography with tandem photo diode array detection and mass spectrometry (LC-PDA-MS) and further ver...

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Detalles Bibliográficos
Autores principales:	Chen, Mei-Ling, Xu, Hong-Xia, Yuan, Wei-Feng, Zhao, Sui-Hong, Li, Xue, Zhu, Lan-Xin, Shen, Zong-Yong, Liu, Yu-Jing, Wang, Ming-Juan, Ma, Ang, Hoogmartens, Jos, Adams, Erwin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9270378/ https://www.ncbi.nlm.nih.gov/pubmed/35804169 http://dx.doi.org/10.1038/s41598-022-15625-5

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