Cargando…
Stimulation-related modifications of evolving functional brain networks in unresponsive wakefulness
Recent advances in neurophysiological brain network analysis have demonstrated novel potential for diagnosis and prognosis of disorders of consciousness. While most progress has been achieved on the population-sample level, time-economic and easy-to-apply personalized solutions are missing. This pro...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9270393/ https://www.ncbi.nlm.nih.gov/pubmed/35803974 http://dx.doi.org/10.1038/s41598-022-15803-5 |
_version_ | 1784744457587916800 |
---|---|
author | Helmstaedter, Christoph Rings, Thorsten Buscher, Lara Janssen, Benedikt Alaeddin, Sara Krause, Vanessa Knecht, Stefan Lehnertz, Klaus |
author_facet | Helmstaedter, Christoph Rings, Thorsten Buscher, Lara Janssen, Benedikt Alaeddin, Sara Krause, Vanessa Knecht, Stefan Lehnertz, Klaus |
author_sort | Helmstaedter, Christoph |
collection | PubMed |
description | Recent advances in neurophysiological brain network analysis have demonstrated novel potential for diagnosis and prognosis of disorders of consciousness. While most progress has been achieved on the population-sample level, time-economic and easy-to-apply personalized solutions are missing. This prospective controlled study combined EEG recordings, basal stimulation, and daily behavioral assessment as applied routinely during complex early rehabilitation treatment. We investigated global characteristics of EEG-derived evolving functional brain networks during the repeated (3–6 weeks apart) evaluation of brain dynamics at rest as well as during and after multisensory stimulation in ten patients who were diagnosed with an unresponsive wakefulness syndrome (UWS). The age-corrected average clustering coefficient C* allowed to discriminate between individual patients at first (three patients) and second assessment (all patients). Clinically, only two patients changed from UWS to minimally conscious state. Of note, most patients presented with significant changes of C* due to stimulations, along with treatment, and with an increasing temporal distance to injury. These changes tended towards the levels of nine healthy controls. Our approach allowed to monitor both, short-term effects of individual therapy sessions and possibly long-term recovery. Future studies will need to assess its full potential for disease monitoring and control of individualized treatment decisions. |
format | Online Article Text |
id | pubmed-9270393 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-92703932022-07-10 Stimulation-related modifications of evolving functional brain networks in unresponsive wakefulness Helmstaedter, Christoph Rings, Thorsten Buscher, Lara Janssen, Benedikt Alaeddin, Sara Krause, Vanessa Knecht, Stefan Lehnertz, Klaus Sci Rep Article Recent advances in neurophysiological brain network analysis have demonstrated novel potential for diagnosis and prognosis of disorders of consciousness. While most progress has been achieved on the population-sample level, time-economic and easy-to-apply personalized solutions are missing. This prospective controlled study combined EEG recordings, basal stimulation, and daily behavioral assessment as applied routinely during complex early rehabilitation treatment. We investigated global characteristics of EEG-derived evolving functional brain networks during the repeated (3–6 weeks apart) evaluation of brain dynamics at rest as well as during and after multisensory stimulation in ten patients who were diagnosed with an unresponsive wakefulness syndrome (UWS). The age-corrected average clustering coefficient C* allowed to discriminate between individual patients at first (three patients) and second assessment (all patients). Clinically, only two patients changed from UWS to minimally conscious state. Of note, most patients presented with significant changes of C* due to stimulations, along with treatment, and with an increasing temporal distance to injury. These changes tended towards the levels of nine healthy controls. Our approach allowed to monitor both, short-term effects of individual therapy sessions and possibly long-term recovery. Future studies will need to assess its full potential for disease monitoring and control of individualized treatment decisions. Nature Publishing Group UK 2022-07-08 /pmc/articles/PMC9270393/ /pubmed/35803974 http://dx.doi.org/10.1038/s41598-022-15803-5 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Helmstaedter, Christoph Rings, Thorsten Buscher, Lara Janssen, Benedikt Alaeddin, Sara Krause, Vanessa Knecht, Stefan Lehnertz, Klaus Stimulation-related modifications of evolving functional brain networks in unresponsive wakefulness |
title | Stimulation-related modifications of evolving functional brain networks in unresponsive wakefulness |
title_full | Stimulation-related modifications of evolving functional brain networks in unresponsive wakefulness |
title_fullStr | Stimulation-related modifications of evolving functional brain networks in unresponsive wakefulness |
title_full_unstemmed | Stimulation-related modifications of evolving functional brain networks in unresponsive wakefulness |
title_short | Stimulation-related modifications of evolving functional brain networks in unresponsive wakefulness |
title_sort | stimulation-related modifications of evolving functional brain networks in unresponsive wakefulness |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9270393/ https://www.ncbi.nlm.nih.gov/pubmed/35803974 http://dx.doi.org/10.1038/s41598-022-15803-5 |
work_keys_str_mv | AT helmstaedterchristoph stimulationrelatedmodificationsofevolvingfunctionalbrainnetworksinunresponsivewakefulness AT ringsthorsten stimulationrelatedmodificationsofevolvingfunctionalbrainnetworksinunresponsivewakefulness AT buscherlara stimulationrelatedmodificationsofevolvingfunctionalbrainnetworksinunresponsivewakefulness AT janssenbenedikt stimulationrelatedmodificationsofevolvingfunctionalbrainnetworksinunresponsivewakefulness AT alaeddinsara stimulationrelatedmodificationsofevolvingfunctionalbrainnetworksinunresponsivewakefulness AT krausevanessa stimulationrelatedmodificationsofevolvingfunctionalbrainnetworksinunresponsivewakefulness AT knechtstefan stimulationrelatedmodificationsofevolvingfunctionalbrainnetworksinunresponsivewakefulness AT lehnertzklaus stimulationrelatedmodificationsofevolvingfunctionalbrainnetworksinunresponsivewakefulness |