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Feedback loop between hepatocyte nuclear factor 1α and endoplasmic reticulum stress mitigates liver injury by downregulating hepatocyte apoptosis

Hepatocyte nuclear factor alpha (HNF1α), endoplasmic reticulum (ER) stress, and hepatocyte apoptosis contribute to severe acute exacerbation (SAE) of liver injury. Here, we explore HNF1α–ER stress-hepatocyte apoptosis interaction in liver injury. LO2, HepG2 and SK-Hep1 cells were treated with thapsi...

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Detalles Bibliográficos
Autores principales:	Liu, Si-Ying, Rao, Jian-Xu, Deng, Jie, Zhang, Gui-Juan, Jiang, Xiao-Ling, Cheng, Jing, Chen, Huan, Jiang, Zhi-Gang, Xu, De-Lin, He, Yi-Huai
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9270423/ https://www.ncbi.nlm.nih.gov/pubmed/35804081 http://dx.doi.org/10.1038/s41598-022-15846-8

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