Lack of Cathepsin D in the central nervous system results in microglia and astrocyte activation and the accumulation of proteinopathy-related proteins

Neuronal ceroid lipofuscinosis is one of many neurodegenerative storage diseases characterized by excessive accumulation of lipofuscins. CLN10 disease, an early infantile neuronal ceroid lipofuscinosis, is associated with a gene that encodes cathepsin D (CtsD), one of the major lysosomal proteases....

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Detalles Bibliográficos
Autores principales: Suzuki, Chigure, Yamaguchi, Junji, Sanada, Takahito, Oliva Trejo, Juan Alejandro, Kakuta, Souichirou, Shibata, Masahiro, Tanida, Isei, Uchiyama, Yasuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9270453/
https://www.ncbi.nlm.nih.gov/pubmed/35804072
http://dx.doi.org/10.1038/s41598-022-15805-3

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