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Eleutheroside E supplementation prevents radiation-induced cognitive impairment and activates PKA signaling via gut microbiota

Radiation affects not only cognitive function but also gut microbiota. Eleutheroside E (EE), a principal active compound of Acanthopanax senticosus, has a certain protective effect on the nervous system. Here, we find a four-week EE supplementation to the (60)Co-γ ray irradiated mice improves the co...

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Autores principales: Song, Chen, Duan, Fangyuan, Ju, Ting, Qin, Yue, Zeng, Deyong, Shan, Shan, Shi, Yudong, Zhang, Yingchun, Lu, Weihong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9270490/
https://www.ncbi.nlm.nih.gov/pubmed/35804021
http://dx.doi.org/10.1038/s42003-022-03602-7
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author Song, Chen
Duan, Fangyuan
Ju, Ting
Qin, Yue
Zeng, Deyong
Shan, Shan
Shi, Yudong
Zhang, Yingchun
Lu, Weihong
author_facet Song, Chen
Duan, Fangyuan
Ju, Ting
Qin, Yue
Zeng, Deyong
Shan, Shan
Shi, Yudong
Zhang, Yingchun
Lu, Weihong
author_sort Song, Chen
collection PubMed
description Radiation affects not only cognitive function but also gut microbiota. Eleutheroside E (EE), a principal active compound of Acanthopanax senticosus, has a certain protective effect on the nervous system. Here, we find a four-week EE supplementation to the (60)Co-γ ray irradiated mice improves the cognition and spatial memory impairments along with the protection of hippocampal neurons, remodels the gut microbiota, especially changes of Lactobacillus and Helicobacter, and altered the microbial metabolites including neurotransmitters (GABA, NE, ACH, 5-HT) as well as their precursors. Furthermore, the fecal transplantation of EE donors verifies that EE alleviated cognition and spatial memory impairments, and activates the PKA/CREB/BDNF signaling via gut microbiota. Our findings provide insight into the mechanism of EE effect on the gut-brain axis and underpin a proposed therapeutic value of EE in cognitive and memory impairments induced by radiation.
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spelling pubmed-92704902022-07-10 Eleutheroside E supplementation prevents radiation-induced cognitive impairment and activates PKA signaling via gut microbiota Song, Chen Duan, Fangyuan Ju, Ting Qin, Yue Zeng, Deyong Shan, Shan Shi, Yudong Zhang, Yingchun Lu, Weihong Commun Biol Article Radiation affects not only cognitive function but also gut microbiota. Eleutheroside E (EE), a principal active compound of Acanthopanax senticosus, has a certain protective effect on the nervous system. Here, we find a four-week EE supplementation to the (60)Co-γ ray irradiated mice improves the cognition and spatial memory impairments along with the protection of hippocampal neurons, remodels the gut microbiota, especially changes of Lactobacillus and Helicobacter, and altered the microbial metabolites including neurotransmitters (GABA, NE, ACH, 5-HT) as well as their precursors. Furthermore, the fecal transplantation of EE donors verifies that EE alleviated cognition and spatial memory impairments, and activates the PKA/CREB/BDNF signaling via gut microbiota. Our findings provide insight into the mechanism of EE effect on the gut-brain axis and underpin a proposed therapeutic value of EE in cognitive and memory impairments induced by radiation. Nature Publishing Group UK 2022-07-08 /pmc/articles/PMC9270490/ /pubmed/35804021 http://dx.doi.org/10.1038/s42003-022-03602-7 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Song, Chen
Duan, Fangyuan
Ju, Ting
Qin, Yue
Zeng, Deyong
Shan, Shan
Shi, Yudong
Zhang, Yingchun
Lu, Weihong
Eleutheroside E supplementation prevents radiation-induced cognitive impairment and activates PKA signaling via gut microbiota
title Eleutheroside E supplementation prevents radiation-induced cognitive impairment and activates PKA signaling via gut microbiota
title_full Eleutheroside E supplementation prevents radiation-induced cognitive impairment and activates PKA signaling via gut microbiota
title_fullStr Eleutheroside E supplementation prevents radiation-induced cognitive impairment and activates PKA signaling via gut microbiota
title_full_unstemmed Eleutheroside E supplementation prevents radiation-induced cognitive impairment and activates PKA signaling via gut microbiota
title_short Eleutheroside E supplementation prevents radiation-induced cognitive impairment and activates PKA signaling via gut microbiota
title_sort eleutheroside e supplementation prevents radiation-induced cognitive impairment and activates pka signaling via gut microbiota
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9270490/
https://www.ncbi.nlm.nih.gov/pubmed/35804021
http://dx.doi.org/10.1038/s42003-022-03602-7
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